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Mycetoma (Madura foot)

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Dec 4, 2010.

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  1. NewsBot

    NewsBot The Admin that posts the news.

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    Mycetoma of the Foot Caused by Madurella Mycetomatis in Immigrants from Sudan.
    Brufman T, Ben-Ami R, Mizrahi M, Bash E, Paran Y.
    Isr Med Assoc J. 2015 Jul;17(7):418-20.
     
  2. NewsBot

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    Eumycetoma Osteomyelitis of the Calcaneus in a Child: A Radiologic-Pathologic Correlation following Total Calcanectomy.
    El-Sobky TA, Haleem JF, Samir S
    Case Rep Pathol. 2015;2015:129020.
     
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    Mycetoma: a unique neglected tropical disease
    Prof Eduard E Zijlstra, PhD, Wendy W J van de Sande, PhD, Prof Oliverio Welsh, DSc, Prof El Sheikh Mahgoub, FRCPath, Prof Michael Goodfellow, DSc, Prof Ahmed H Fahal, FRCS
    Lancet Infectious Diseases; Volume 16, No. 1, p100?112, January 2016
     
  5. NewsBot

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    Mycetoma: a unique neglected tropical disease.
    Zijlstra EE et al
    Lancet Infect Dis. 2016 Jan;16(1):100-12
     
  6. NewsBot

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    Madura foot in Europe: diagnosis of an autochthonous case by molecular approach and review of the literature.
    Mencarini J et al
    New Microbiol. 2016 Feb;39(2):156-159.
     
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    Role of a NSAID in the apparent cure of a fungal mycetoma.
    Dupont B et al
    J Mycol Med. 2016 May 24.
     
  8. NewsBot

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    Madura foot caused by Gordonia terrae misdiagnosed as Nocardia.
    Zampella JG et al
    Australas J Dermatol. 2016 Jun 7. doi: 10.1111/ajd.12516
     
  9. NewsBot

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    The Surgical Treatment of Mycetoma
    Suleiman Hussein Suleiman, EL Sammani Wadaella, Ahmed Hassan Fahal
    PLoS Negl Trop Dis 10(6): e0004690
     
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    Mycetoma in a non-endemic area: a diagnostic challenge.
    Efared B et al
    BMC Clin Pathol. 2017 Feb 2;17:1. doi: 10.1186/s12907-017-0040-5. eCollection 2017.
     
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    Dot-in-Circle Sign - A Diagnostic MRI Sign for "Madura Foot".
    Javed F et al
    J Coll Physicians Surg Pak. 2017 Mar;27(3):S8-S10. doi: 236.
     
  13. NewsBot

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    Mycetoma (Madura Foot) in Israel: Recent Cases and a Systematic Review of the Literature
    Ohad Bitan, Yonit Wiener-Well, Rina Segal and Eli Schwartz
    The American Journal of Tropical Medicine and Hygiene; 03 April 2017
     
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    PUBLIC RELEASE: 19-JUN-2017
    Clinical trial for a better treatment for mycetoma starts in Sudan
    First ever double-blind study for disease so neglected that it only recently was added to WHO list of neglected tropical diseases
    The first-ever double-blind, randomized clinical trial for an effective treatment for the severely neglected disease mycetoma has enrolled its first patient at the Mycetoma Research Centre (MRC) in Khartoum, Sudan.

    Mycetoma is a chronic infection mainly of the foot that may spread to other parts of the body and causes severe deformity. Infection probably comes from the soil or animal dung, and it is thought that most patients are infected by walking barefoot and thus sustain minor cuts of thorns of the acacia tree.

    The disease is endemic in tropical and subtropical areas of what is coined the 'mycetoma belt', which includes Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan, and Yemen. Most countries are located between 30°N and 15°S, with Sudan the epicenter of the disease. It affects the poorest of the poor in poor remote communities. It has severe negative impacts on patients, families, communities and health authorities in endemic areas.

    The trial seeks to compare the efficacy of a potential new treatment, fosravuconazole, to the existing therapy in people suffering from moderate eumycetoma, the fungal form of mycetoma. Today, the existing anti-fungal treatments for people suffering from eumycetoma only cure a fraction of patients, have a long treatment duration of a minimum of 12 months, are toxic, and cost an equivalent to more than a month's wage in the rural community. This means that the treatment is beyond the incomes of many rural poor and consequently affected patients often need an amputation to control the infection. In some the disease runs a fatal course.

    "With the first patient enrolled now, what we have been working towards for the last ten years is at last a reality," said Dr Ahmed Fahal, Professor of Surgery at the University of Khartoum and Director of the MRC. "An effective, safe, affordable and shorter-term curative treatment which is appropriate for rural settings is desperately needed for neglected patients suffering from mycetoma."

    The study is being conducted by Drugs for Neglected Diseases initiative (DNDi) and the MRC together with Eisai Co., Ltd a Japanese pharmaceutical company which is providing the trial drug fosravuconazole. Since the intention to carry out the study was announced, the MRC has been preparing by following up national regulatory body approvals, strengthening laboratory functions and training of the MRC staff. Screening of potential patients began at the beginning of the month of May and the first patient was enrolled soon after.

    "This important milestone comes one year after the landmark decision to include mycetoma in the list of the World Health Organization's official list of neglected tropical diseases," said Dr Nathalie Strub-Wourgaft, Medical Director, DNDi. "We are finally starting to roll the ball towards ending the neglect of patients suffering from mycetoma."
     
  16. NewsBot

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    Mycetoma: An update.
    Relhan V, Mahajan K, Agarwal P, Garg VK.
    Indian J Dermatol 2017;62:332-40 (full text)
    Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult. Serological test exists but is not so reliable; however, molecular techniques to identify relevant antigens have shown promise. The disease is notoriously difficult to treat. Eumycetoma may be unresponsive to standard antifungal therapy. Actinomycetoma responds to antibiotic therapy, but prolonged treatment is necessary.This review focuses on the etiopathogenesis, clinical features, laboratory diagnosis, and treatment of mycetoma.
     
  17. NewsBot

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    Mycetoma: An Update.
    Relhan V et al
    Indian J Dermatol. 2017 Jul-Aug;62(4):332-340. doi: 10.4103/ijd.IJD_476_16.
     
  18. NewsBot

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    Actinomycosis of the foot - A South African case.
    Polden KE, Jehle H
    S Afr J Surg. 2017 Jun;55(2):36.
     
  19. NewsBot

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    Closing the mycetoma knowledge gap
    Wendy van de Sande Ahmed Fahal Sarah Abdalla Ahmed Julian Alberto Serrano Alexandro Bonifaz Ed Zijlstra on behalf of the eumycetoma working group
    Medical Mycology, 09 September 2017
     
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    Actinomycotic Mycetoma of Right Foot: A Case report
    From Central India

    Avtar Kishan Jaisinghani, Veena Maheshwari, Sanjo Gupta
    People’s Journal of Scientific Research July 2017; Volume 10, Issue 2
     
  21. NewsBot

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    Closing the mycetoma knowledge gap.
    van de Sande W et al
    Med Mycol. 2017 Sep 9. doi: 10.1093/mmy/myx061.
     
  22. NewsBot

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    A holistic approach to the mycetoma management
    Sahar Mubarak Bakhiet, Ahmed Hassan Fahal , Ahmed Mudawi Musa, El Samani Wadaa Mohamed, Rowa Fathelrahman Omer, Eiman Siddig Ahmed, Mustafa El Nour, El Rayah Mohamed Mustafa, Manar El Sheikh A. Rahman, Suliman Hussein Suliman, Mohamed A. Gadir El Mamoun, Hajo Mohamed El Amin
    https://doi.org/10.1371/journal.pntd.0006391
     
  23. NewsBot

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    Chronic Madura foot: mycetoma and/or Actinomyces spp or actinomycosis.
    Al Gannass A
    BMJ Case Rep. 2018 May 22;2018.
     
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    Madura foot: an imported case of a non-common diagnosis.
    Fasciana T et al
    Infez Med. 2018 Jun 1;26(2):167-170.
     
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    Treatment of Madura foot: a systematic review.
    Salim AO et al
    JBI Database System Rev Implement Rep. 2018 Jul;16(7):1519-1536. doi: 10.11124/JBISRIR-2017-003433.
     
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    A Call to Action for Mycetoma
    Karlyn D. Beer et al
    Epidemiology of Fungal Infections: 18 July 2018
     
  27. NewsBot

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    Mycetoma: a clinical dilemma in resource limited settings
    Pembi Emmanuel et al
    Annals of Clinical Microbiology and Antimicrobials201817:35
     
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    Mycetoma-A resurgence
    Kumar M. Mani Surya et al
    Indian Journal of Clinical and Experimental Dermatology 24 September, 2018.
     
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    The importance of diagnostic imaging of mycetoma in the foot.
    Guerra-Leal JD et al
    Int J Dermatol. 2018 Dec 18.
     
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    Interleukin-17 and matrix metalloprotease-9 expression in the mycetoma granuloma
    Emmanuel Edwar Siddig , Ali Mahmoud Mohammed Edris, Sahar Mubarak Bakhiet, Wendy W. J. van de Sande, Ahmed Hassan Fahal
    July 11, 2019
     
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    Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region.
    Karrakchou B et al
    BMC Dermatol. 2020 Jan 10
     
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    Soft tissue mycetoma: "Dot-in-circle" sign on magnetic resonance imaging.
    Basirat A et al
    Radiol Case Rep. 2020 Feb 22
     
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    Characterization of Foot Mycetoma Using Sonography and Color Doppler Imaging
    Moawia Gameraddin, Awadia Gareeballah, Shimaa Mokhtar, Mohamed M Abuzaid, Fahad Alhazmi, Hassan Ali Hamad
    Pak J Biol Sci. 2020 Jan;23(7):968-972
     
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    Treatment criteria for madura foot: Case report and literature review
    Wathmi Wijesinghe et al
    The Foot and Ankle Online Journal 13 (3): 10
     
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    Madura's foot: reasons for the delay in diagnosis and consequences for the management (a case report)
    Baudouin Boanimbek et al
    Pan Afr Med J. 2020 Sep 18;37:75
     
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    A study of 87 mycetoma patients seen at three health facilities in Nouakchott, Mauritania
    M Kébé et al
    Trans R Soc Trop Med Hyg. 2021 Feb 13
     
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    Eumycetoma of the Foot due to Fusarium solani in a Person with Diabetes Mellitus: Report of a Case and Review of Literature
    Liza Das et al
    Mycopathologia. 2021 Mar 9
     
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    Knowledge, attitude, practice and associated factors of health professionals towards podoconiosis in Gamo zone, Ethiopia, 2019
    Chuchu Churko et al
    J Foot Ankle Res. 2021 Apr 14;14(1):31
     
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    Chronic Painless, Multiple Papulo-Nodular Skin Lesion at Foot Resembles Mycetoma Infection (Madura Foot): A Case Report
    Ahmed Suparno Bahar Moni, Md M Hoque
    Int J Low Extrem Wounds. 2021 Jul 5
     

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