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Arthrogryposis Multiplex Congenita

Discussion in 'Foot Surgery' started by NewsBot, Jun 27, 2015.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    Treatment of Foot Deformities in Arthrogryposis Multiplex Congenita
    Bart Kowalczyk, MD, PhD; Jaroslaw Feluś, MD, PhD
    JBJS Reviews, 2015 Jun; 3 (6): e4. http://dx.doi.org/10.2106/JBJS.RVW.N.00103
     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Results of Primary Talectomy for Clubfoot in Infants and Toddlers with Arthrogryposis Multiplex Congenita.
    Chotigavanichaya C, Ariyawatkul T, Eamsobhana P, Kaewpornsawan K
    Journal of the Medical Association of Thailand = Chotmaihet Thangphaet [2015, 98 Suppl 8:S38-41
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Gait dynamics in the wide spectrum of children with arthrogryposis: a descriptive study.
    Eriksson M et al
    BMC Musculoskelet Disord. 2015 Dec 9;16(1):384.
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Challenging clubfeet: the arthrogrypotic clubfoot and the complex clubfoot.
    van Bosse HJP
    J Child Orthop. 2019 Jun 1;13(3):271-281
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Treatment and outcomes of arthrogryposis in the lower extremity.
    Hamdy RC et al
    Am J Med Genet C Semin Med Genet. 2019 Sep 3
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    The 5-Year Outcome of the Ponseti Method in Children With Idiopathic Clubfoot and Arthrogryposis.
    Church C et al
    J Pediatr Orthop. 2020 Feb 6
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Disability and Quality of Life After Talectomy for Arthrogryposis Multiplex Congenita
    Ahmet Sevencan et al
    Foot Ankle Int. 2022 Jun 14
     
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Talectomy for Arthrogrypotic Foot Deformities: A Systematic Review
    SamiCherguiHussainAl-AliYousefMarwanKhaled AbuDaluNoémiDahan-OlielReggie C.Hamdy
    Foot and Ankle Surgery; 15 October 2022
     
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    Articles:
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    The Effectiveness of Serial Casting in the Treatment of Recurrent Equinovarus in Children With Arthrogryposis
    Chris Church et al
    J Pediatr Orthop. 2023 Feb 1;43(2):117-122
     
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    NewsBot The Admin that posts the news.

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    News Release 12-Jan-2023
    Oversensitive sensory neurons can cause joint deformities

    Excessive mechanosensation in the neurons that enable the sense of one’s limbs in space can disrupt musculoskeletal development and cause joint deformities like arthrogryposis, researchers report. Their study also provides proof of concept that reducing this heightened sensory neuronal activity (via Botox or special diet) during a critical age could be a viable way to treat some musculoskeletal conditions in a non-invasive manner. Distal arthrogryposis (DA) is a disorder characterized by congenital joint deformities, or contractures, that often restrict movement in the hands and feet and is estimated to afflict roughly one in 3,000 individuals worldwide. Alleviating the symptoms often requires invasive surgeries. Although mutations in genes associated with muscle and joint function have been linked to DA, gain-of-function mutations in PIEZO2 – a principal mechanosensor in sensory neurons that underlies touch sensation, proprioception, and other mechanosensory processes – have been found in patients with DA subtype 5 (DA5). However, the mechanism by which PIEZO2 mutations cause DA is unknown. Using a mouse model, Shang Ma and colleagues found that over-expression of the mutant Piezo2 gain-of-function allele in proprioceptive neurons that enervate muscles and tendons during a critical postnatal period during development can cause joint contracture. These defects were not caused when the dysfunctional allele was expressed in skeletal muscles, cartilage, or tendons. According to Ma et al., Botox injection and a dietary fatty acid commonly found in fish reduced joint and tendon defects. “The study by Ma et al. provides exciting new insights into the mechanisms that cause DA,” writes Urich Müller in a related Perspective. “Finding that expression of the gain-of-function allele of Piezo2 in young adult mice does not cause DA symptoms is reassuring. It narrows down a time window for potential therapeutic intervention that could lead to lifelong improvement for the affected patients.”
     

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