Trace Elements in Serum and Toenail Samples of Patients with Onychocryptosis and Onychomycosis

NewsBot · Apr 14, 2020

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Level of Trace Elements in Serum and Toenail Samples of Patients with Onychocryptosis (ingrown toenail) and Onychomycosis
EvrenKilinc et al
Journal of Trace Elements in Medicine and Biology 30 March 2020, 126509

Highlights
•Mg level was higher in the onychomycosis group regardless of age, sex and smoking.
•Trace element levels in toenails with onychocryptosis were comparable to controls.
•Serum levels of these trace elements were similar in all groups.
•Blood cell counts in participants of each group were comparable.
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Background
Onychocryptosis (ingrown toenail) and onychomycosis are common pathologies of the toenail and affecting many people. Since levels of trace elements have been shown to vary in certain diseases, in the presented work, chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se), and zinc (Zn) levels of toenail and serum samples of healthy individuals and patients with onychocryptosis and onychomycosis were compared.

Methods
Serum and toenail samples of 88 voluntary subjects (healthy n = 24; onychomycosis n = 24; onychocryptosis n = 40) aged between 19-80 years were collected. Levels of trace elements in the samples were analyzed by using an inductively coupled plasma-optical emission spectrophotometer (ICP-OES Thermo iCAP - 6000). The differences in medians between the groups for elements were evaluated with Kruskal -Wallis H test with post hoc for pairwise comparisons in SPSS 18.

Results
Mg (p < 0.001) and Mn (p = 0.002) levels were significantly increased whereas Zn (p = 0.011) level was decreased in toenails of patients with onychomycosis compared to healthy subjects. Although Mg and Mn levels were higher in female subjects with onychomycosis (p = 0.001; p = 0.019), Mn was only increased in male subjects (p = 0.015). Mg was the only trace element found to be independent of sex, age, and smoking status in patients with onychomycosis. However, no significant difference has been found in serum trace element levels neither between any groups nor toenail trace element levels of patients with onychocryptosis and healthy subjects.

Conclusion
As a response of the human body to pathogens like fungi in toenails, Mg, Mn and Zn levels vary. Especially the role of Mg ions in onychomycosis needs to be investigated more specifically.
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NewsBot · Apr 14, 2020

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Toenail Manganese as Biomarker of Drinking Water Exposure: A Reliability Study From a US Pregnancy Cohort
Antonio J Signes-Pastor et al
J Expo Sci Environ Epidemiol. 2019 Sep;29(5):648-654

Manganese (Mn) is an essential nutrient; however, overexposure can be neurotoxic. Recent evidence suggests that exposure to Mn from drinking water could be neurotoxic; however, research is hampered by the lack of consensus on a reliable biomarker of Mn exposure. Naturally high concentrations of Mn can occur in groundwater, particularly for private, unregulated water systems. This study aimed to investigate the association between exposure to Mn from drinking water with a relatively low Mn content (median of 2.9 μg/L; range, undetectable-8,340 μg/L) and Mn in toenails from women collected at two time points: during and after pregnancy. Mn concentrations in the paired toenail samples gathered during the second to third trimester of pregnancy and 2 weeks postpartum were correlated (r = 0.47, p < 0.001, n = 596). Among women consuming drinking water Mn in the highest tertile (i.e., > 9.8 μg/L) significant positive correlations were found between water Mn and toenails Mn (r = 0.31 and r = 0.38, for toenail samples collected during pregnancy and postpartum, respectively), whereas little to no correlation was observed at lower water concentrations. Overall, our data suggest that maternal toenail samples are a reliable environmental Mn exposure biomarker and reflect exposure from drinking water.
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Trace Elements in Serum and Toenail Samples of Patients with Onychocryptosis and Onychomycosis

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Trace Elements in Serum and Toenail Samples of Patients with Onychocryptosis and Onychomycosis

NewsBot The Admin that posts the news.

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Anti-pronator elements of foot orthotics

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