Welcome to the Podiatry Arena forums

You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members, upload content, view attachments, receive a weekly email update of new discussions, access other special features. Registered users do not get displayed the advertisements in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!

  1. Everything that you are ever going to want to know about running shoes: Running Shoes Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
  2. Have you considered the Critical Thinking and Skeptical Boot Camp, for taking it to the next level? See here for more.
    Dismiss Notice
  3. Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
Dismiss Notice
Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
Dismiss Notice
Have you liked us on Facebook to get our updates? Please do. Click here for our Facebook page.
Dismiss Notice
Do you get the weekly newsletter that Podiatry Arena sends out to update everybody? If not, click here to organise this.

Botulinum toxin and plantar fasciitis

Discussion in 'Biomechanics, Sports and Foot orthoses' started by admin, Sep 7, 2005.

  1. admin

    admin Administrator Staff Member


    Members do not see these Ads. Sign Up.
    Babcock MS, Foster L, Pasquina P, Jabbari B: Treatment of pain attributed to plantar fasciitis with botulinum toxin A: A short-term, randomized, placebo-controlled, double-blind study. Am J Phys Med Rebabil 2005;84:649-654.

     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Hee is another new study on this

    Treatment of chronic plantar fasciitis with botulinum toxin a: preliminary clinical results.
    Clin J Pain. 2006 Feb;22(2):190-2
     
  3. I don't know much about botox a other than it effects ACH at the neuro-muscular synapse and hence inhibits muscle function. Given that the plantar fascia isn't a muscle, what effect is the botox having here, is it simply acting on the pain receptors? Or does this work suggest that pain may be coming from the plantar intrinsics originating in this area?
     
  4. John Spina

    John Spina Active Member

    Botox is also said to do well for hyperhidrosis at the plantar aspect.It is supposed to work for about 6 months for 1 injection.I have no experience with this.
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    botox

    Autologous Blood Injection and Botulinum Toxin for Resistant Plantar Fasciitis Accompanied by Spasticity.
    Am J Phys Med Rehabil. 2006 Aug;85(8):699-703
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Botulinum Toxin

    Treatment of Chronic Plantar Fasciitis with Botulinum Toxin A - An Open Pilot Study on 25 Patients with a 14-Week-Follow-up
    [Article in German]
    Placzek R, Holscher A, Deuretzbacher G, Meiss L, Perka C.
    Z Orthop Ihre Grenzgeb. 2006 Jul-Aug;144(4):405-9.
     
  8. Does anyone have any further ideas on Botox and Plantar fasciitis. I had an email this morning wanting my advice on the injection. Ive not seen the patient so said I could not give advice, but was wondering what the lastest. If anything? Anyone had any patient try it out with +ve ot -ve results ?
     
  9. Mart

    Mart Well-Known Member

    This seems most plausible to me. If there is fasciosis (mucoid degeration) or partial rupture, overload (protective or inavoidable) of intimate FDB or AbHal would seem likely if not neccessary. Intersting though if botox reduced contibution from them what would pick up tensile load?

    cheers

    Martin

    The St. James Foot Clinic
    1749 Portage Ave.
    Winnipeg
    Manitoba
    R3J 0E6
    phone [204] 837 FOOT (3668)
    fax [204] 774 9918
    www.winnipegfootclinic.com
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Ultrasonographic guided botulinum toxin type A treatment for plantar fasciitis; an outcome-based investigation for treating pain and gait changes.
    Huang YC, Wei SH, Wang HK, Lieu FK.
    J Rehabil Med. 2010 Feb;42(2):136-40.
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Serial Ultrasonographic Findings of Plantar Fasciitis After Treatment With Botulinum Toxin A: A Case Study.
    Chou LW, Hong CZ, Wu ES, Hsueh WH, Kao MJ.
    Arch Phys Med Rehabil. 2011 Feb;92(2):316-319.
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Serial ultrasonographic findings of plantar fasciitis after treatment with botulinum toxin a: a case study.
    Endo Y.
    Ultrasound Q. 2011 Sep;27(3):202.
    (no abstract publicly available)
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Treatment of Refractory Pain with Botulinum Toxins-An Evidence-Based Review.
    Jabbari B, Machado D.
    Pain Med. 2011 Sep 29. doi: 10.1111/j.1526-4637.2011.01245.x. [Epub ahead of print]
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Randomized controlled study of the efficacy of the injection of botulinum toxin type A versus corticosteroids in chronic plantar fasciitis: results at one and six months.
    Diaz-Llopis IV, Rodriguez-Ruiz CM, Mulet-Perry S, Mondejar-Gomez FJ, Climent-Barbera JM, Cholbi-Llobel F.
    Clin Rehabil. 2011 Dec 1.
     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Is botulinum toxin a effective for the treatment of plantar fasciitis?
    Peterlein CD, Funk JF, Hölscher A, Schuh A, Placzek R.
    Clin J Pain. 2012 Jul;28(6):527-33.
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical trial was just registered:

    Treatment of Plantar Fasciitis With Xeomin
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    A Comparison of Botulinum Toxin A and Intralesional Steroids for the Treatment of Plantar Fasciitis: A Randomized, Double-Blinded Study
    Jorge Elizondo-Rodriguez, et al
    Foot & Ankle International January 2013 vol. 34 no. 1 8-14
     
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Botox beats steroids for painful foot condition, plantar fasciitis
     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Botulinum toxin type A in chronic plantar fasciitis: clinical effects one year after injection.
    Díaz-Llopis IV, Gómez-Gallego D, Mondéjar-Gómez FJ, López-García A, Climent-Barberá JM, Rodríguez-Ruiz CM.
    Clin Rehabil. 2013 Feb 14.
     
  20. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical trial was just registered:
    Botulinum Toxin A Versus Steroids for the Treatment of Chronic Plantar Fasciitis
     
  22. Pod on sea

    Pod on sea Active Member

    It seems there's a lot of research going on. I've just been asked by a patient about Botox for plantar heel pain. Is anyone in the UK using it? Has anyone seen any patients who have had it done?
    Thanks
     
  23. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Botulinum Toxin Treatment of Plantar Fasciitis (Plantar Fasciopathy)
    Bahman Jabbari
    Botulinum Toxin Treatment of Pain Disorders; 2015, pp 85-97
     
  24. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Comparison of extracorporeal shock wave therapy with botulinum toxin type A in the treatment of plantar fasciitis
    Bernardino Rocaa, Mar?a A. Mendozaa & Manuel Rocaa
    Disability and Rehabilitation; 01 Mar 2016
     
  25. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Treatment of Plantar Fasciitis With Botulinum Toxin
    A Randomized, Controlled Study

    Jamal Ahmad et al
    Foot & Ankle International September 14, 2016
     
  26. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Revance Announces Initiation of Phase 2 Trial of RT002 Injectable to Treat Plantar Fasciitis
    November 03, 2016 08:00 AM Eastern Daylight Time
     
  27. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  28. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Botulinum Toxin Injections in Musculoskeletal Disorders
    Ivan R.B. Godoy et al
    Semin Musculoskelet Radiol 2016; 20(05): 441-452
     
  29. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical trial was just registered:
    Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.
     
  30. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  31. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Revance Provides Update on Phase 2 Program for RT002 Injectable in the Management of Plantar Fasciitis
    May 01, 2017
    NEWARK, Calif.--(BUSINESS WIRE)--Revance Therapeutics, Inc. (NASDAQ:RVNC), a biotechnology company developing botulinum toxin products for use in treating aesthetic and therapeutic conditions, today announced that it is expanding the Company’s Phase 2 program investigating the use of DaxibotulinumtoxinA for Injection (RT002) for the management of plantar fasciitis from a single center to a multi-center study with protocol updates. Revance expects to report topline results from the Phase 2 study in the fourth quarter of 2017.

    “We are very excited about the potential use of RT002 to treat plantar fasciitis, which causes severe pain and inflammation along the bottom of the foot, especially in the heel area,” said Dan Browne, President and Chief Executive Officer at Revance. “We have moved from a single center to a multi-center study protocol, including Wake Forest Baptist Medical Center and two new non-academic study sites, to help us meet our enrollment goals and report topline safety and efficacy results for the plantar fasciitis program before year-end. The combination of a validated visual analog scale (VAS) for measuring the reduction of pain in the foot as a primary endpoint and the improvement in the American Orthopaedic Foot and Ankle Score (AOFAS) as a secondary endpoint provide for clinically meaningful measurements of RT002’s ability to reduce the pain associated with plantar fasciitis. We believe these changes strengthen the Phase 2 program’s capacity to assess the use of RT002 to treat plantar fasciitis.”

    The study protocol has been submitted to the U.S. Food and Drug Administration and is scheduled to post on clintrials.gov this week. Recruitment and screening of patients under the new study protocol is already underway.

    Phase 2 Study Design:
    This Phase 2 prospective, randomized, double-blinded, placebo-controlled, multi-center study will evaluate the safety and efficacy of a single administration of Revance’s investigational drug candidate DaxibotulinumtoxinA for Injection (RT002) in reducing the signs and symptoms of plantar fasciitis. This study is expected to enroll approximately 60 subjects across three centers in the United States. The study’s primary efficacy endpoint is the reduction in the visual analog scale (VAS) for pain in the foot. Improvement in the American Orthopaedic Foot and Ankle Score (AOFAS) is one of several secondary endpoints. Subjects will be followed for 16 weeks post treatment.

    About Plantar Fasciitis:
    Heel pain is the most common complaint of patients who visit podiatrists and orthopeadic foot and ankle surgeons. Eighty percent of reported heel pain complaints are due to plantar fasciitis, which is caused by inflammation of the connective tissue in the arch of the foot.1 Plantar fasciitis is estimated to affect 10 to 18 million individuals in the United States annually.2 Risk factors include age, long distance running, excessive weight, abnormal foot posture, use of poor foot wear, and repetitive trauma.3

    Treatment options for less severe cases include leg and foot stretching exercises, nonsteroidal anti-inflammatory drugs, shoe inserts, heel pads, and night splints. More severe or refractory cases are currently treated with steroid injections, extracorporeal shock wave therapy, platelet rich plasma injections, and/or surgery.4

    About Revance Therapeutics, Inc.
    Revance, a Silicon Valley-based biotechnology company, is committed to the advancement of remarkable science. The company is developing a portfolio of products for aesthetic medicine and underserved therapeutic specialties, including dermatology, orthopedics and neurology. Revance’s science is based upon a proprietary peptide technology, which when combined with active drug molecules, may help address current unmet needs. Revance’s initial focus is on developing daxibotulinumtoxinA, the company’s highly purified botulinum toxin, for a broad spectrum of aesthetic and therapeutic indications, including facial wrinkles and muscle movement disorders.

    The company’s lead drug candidate, DaxibotulinumtoxinA for Injection (RT002), is currently in development for the treatment of glabellar lines, cervical dystonia and plantar fasciitis with the potential to be the first long-acting neuromodulator. The company holds worldwide rights to RT002 injectable and RT001 topical and the pharmaceutical uses of its proprietary peptide technology platform. More information on Revance may be found at www.revance.com.

    “Revance Therapeutics” and the Revance logo are registered trademarks of Revance Therapeutics, Inc.
     
Loading...

Share This Page