Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years

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Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years.
Sigurgeirsson B, Olafsson JH, Steinsson JT, Kerrouche N, Sidou F.
J Eur Acad Dermatol Venereol. 2010 Aug;24(8):910-5.

 

Very interesting, but what about the side effects of long term use of ANL ? Interesting results thought, thanks very much , Roadrunner

 

You have to aske why it is reoccuring?
Here in Oz, all too many people have their washing machines only connected to the COLD tap. I have educated a few people in the importance of HOT washing of socks and wiping out your shoes with vinegar (old Valet trick). Socks are cheap. That said of course, lots of people do walk barefoot in the sun here.
Prevention should be taught.

 

also tea tree oil very useful in small doses, my dad who was recently diagnosed with diabetes, before he was diagnosed developed a fungal rash on his foot, i said go to gp , he did got blood test and hey presto i was right. also developed fungal nail. Has been using tea tree oil for six months now and there is a vast improvement. fungal skin disease can tell us a lot about the pre diagnosis of diabetes. by the way I was right! - bloke who finds out she is a mermaid - splash the mermaid movie - favourite film of all time!

 

Tea Tree oil has been well documented to be useless and is facing a ban by the EU because of its side effects.

You need to avail yourself of the evidence: Is there a place for tea tree oil in foot care?

 

you need to learn some manners lady!

 

this is a very rude forum think i m better with professor pod!

 

Murphycat

I am going to agree with DaVinci.
It is evident that tea tree oil does work against microbial species that cause tinea pedis by disintegrating cell membrane of the guilty agent. However it is even more evident to cause more side effects such as contact dermatitis.
Still there is insufficient evidence what should be threshold amount of its use thus I would be reluctant to use it.

 

Do you know of any side effects associated with long term use, other than the ones advised on the pt info leaflet? i.e. less than 1 in 10,000 people experience nail discolouration and fragility or contact dermatitis.

Amorolfine has been used in numerous clinical trials to show that the benefits of taking the medicine outweigh the risks. The following paper highlights how combination treatment with amorolfine and two pulses of itraconazole is at least as safe and effective as three pulses of itraconazole, with the additional benefit of a lower cost per patient...

http://www.ncbi.nlm.nih.gov/pubmed/12890209

:good: Yep, what Mario says.

Cheers,
Bel

 

Interesting. In the Newcastle Uni clinic, there is a bottle of TeaTree oil in every drawer. We splash it around on any suspect fungus. I have read the 'useless' info about TT too, but Aussies use it on bites, rashes, etc Could it be that we use a larger dose, or mor frequently?
It's all Thursday Island brand here.
Mind you, the literature on Amorolfine is not exactly good, 52% cure to my memory, and patient compliance is a problem. I have always questioned my patients, and it works best for people who read the leaflet and follow directions....and have the time to do it.

 

Carol,

I admit I was using it in my uni days as well as advising patients to take although they should seek medical advice prior its use.
What you saying I find it quite fascinating?! What sort of dosage you use? . And what kind of rashes are you talking about? Since the common side effect of tea tree oil is that causes dermatitis.

Regards

 

Mario, We do ask if any prior reactions to it, but I have yet to have someone claim dermatitis or a rash from it. I have a friend in Singapore who says she is allergic to it, but the heat in Singapore may change the reaction on the skin. Every Aussie house has a bottle, I personally put it in the rinse cycle for bed linen and socks. Happy New Year from Sydney, 31C and mosquitoes on the rampage....Where's my TT?

 

Perhaps TT has antihistamine properties after all. :bash: Obviously it is up to people to decide if they want to use it. In my case I decide not to suggest it to my patients since there is inadequate research on the benefits of using it. The research (majority) so far conducted is full of publication bias.

Very warm indeed. How lovely!!!! :santa2: A bit cold here however is much better than last week.

Happy New Year Carol!!!

 

I would have though that University teaching clinics should be "centres" of evidence based practice! The in vitro evidence is that is that it has anti-fungal properties, but the in vivo evidence is that its useless. Its no better than a placebo, so I think you should really question why its being used. Other anti-fungal agents have been shown to be better than a placebo.

 

only maybe why not try some real research without lining the pockets of the pharmaceutical company!

 

Care to contribute something useful and tell us what you think is actually wrong with this study?

 

Amorolfine Nail lacquer (ANL) is better for single nail contamination and for superficial and distal nailplate involvement with< 50% nailplate involvement.