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Statins and tendon complications

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Feb 29, 2008.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

    Members do not see these Ads. Sign Up.
    ScienceDaily are reporting:
    Tendon Complications, Though Rare, Linked To Statins, Study Shows
    Full story
     
  2. Admin2

    Admin2 Administrator Staff Member

  3. Trent Baker

    Trent Baker Active Member

    This is a helpfull research paper. I know it's rare, however something that all of us should be aware of. I have plenty of patients on lipid modifying medication, some of which are still quite young and active. It seems this may put them in a higher risk category for tendon complications.

    My Father in-law has extremely high cholesterol and has been a marathon runner most of his life (he is a butcher though, loves a snag) and recently had a tripple bi-pass. He has always been plagued by achilles problems, not that he lets me have a look, you know the son-in-law thing. I'm not sure of his medication, I'm keen to have a look now though.

    Trent
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Medscape Medical News are reporting:
    Muscle Pain and Weakness With Statin Treatment May Herald ALS
    From American Neurological Association (ANA) 133rd Annual Meeting
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Simultaneous bilateral Achilles tendon ruptures associated with statin medication despite regular rock climbing exercise.
    Carmont MR, Highland AM, Blundell CM, Davies MB.
    Phys Ther Sport. 2009 Nov;10(4):150-2.
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of Statins on Skeletal Muscle: A Perspective for Physical Therapists
    Stephanie L. Di Stasi, Toran D. MacLeod, Joshua D. Winters and Stuart A. Binder-Macleod
    Physical Therapy October 2010 vol. 90
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    THE LINK BETWEEN DYSLIPIDEMIA AND TENDON PATHOLOGY
    N Grewal, D Granville, D Reid, A Scott
    2nd International Scientific Tendinopathy Symposium; Vancouver Sept 27-29 2012
     
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Press Release:
    Musculoskeletal Conditions, Injuries May Be Associated with Statin Use
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Statins and Musculoskeletal Conditions, Arthropathies, and Injuries
    Ishak Mansi, MD; Christopher R. Frei, PharmD, MSc; Mary Jo Pugh, PhD; Una Makris, MD; Eric M. Mortensen, MD, MSc
    JAMA Intern Med. 2013;():1-9.
     
  10. Craig Payne

    Craig Payne Moderator

    Articles:
    8
    How about this one!

    A patent was granted to treat this:
    HYPERCHOLESTEROLEMIA AND TENDINOUS INJURIES
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Statins induce biochemical changes in the Achilles tendon after chronic treatment
    Letícia Prado de Oliveira, Cristiano Pedrozo Vieira, Flávia Da Ré Guerra, Marcos dos Santos Almeida, Edson Rosa Pimentel
    Toxicology; Available online 4 July 2013
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Simvastatin-lnduced nocturnal leg pain disappears with pravastatin substitution.
    Stojaković N, Igić R.
    Srp Arh Celok Lek. 2013 May-Jun;141(5-6):387-9.
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Structural and biomechanical changes in the achilles tendon after chronic treatment with statins
    L.P. Oliveiraa, C.P. Vieiraa, F.D. Guerraa, M.S. Almeidaa, E.R. Pimentela
    Food and Chemical Toxicology; Available online
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Statin-induced bilateral foot drop in a case of hypothyroidism.
    Chaudhary N et al
    Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):331-4
     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Prevention of simvastatin-induced inhibition of tendon cell proliferation and cell cycle progression by geranylgeranyl pyrophosphate
    Wen-Chung Tsai et al
    Toxicol. Sci. (2015) doi: 10.1093/toxsci/kfv239
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Statins and tendinopathy: a systematic review
    Andrew J Teichtahl, Sharmayne RE Brady, Donna M Urquhart, Anita E Wluka, Yuanyuan Wang, Jonathan E Shaw and Flavia M Cicuttini
    Med J Aust 2016; 204 (3): 115-121.
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Do different tendons exhibit the same response following chronic exposure to statins?
    Letícia Oliveira, Cristiano Vieira, Petrus Marques, Edson Pimentel
    Canadian Journal of Physiology and Pharmacology, 10.1139/cjpp-2016-0133
     
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Association Between Statin Use and Prevalence of Exercise-Related Injuries: A Cross-Sectional Survey of Amateur Runners in the Netherlands
    Authors

    Bakker, E.A., Timmers, S., Hopman, M.T.E. et al.
    Sports Med (2017). doi:10.1007/s40279-017-0681-7
     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    A CROSS-SECTIONAL STUDY TO EVALUATE THE EFFECT OF STATINS ON
    ACHILLES TENDON MORPHOLOGY USING ULTRASOUND TISSUE
    CHARACTERIZATION.

    Agnetha de Sá
    Thesis, The University of British Columbia
     
  20. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    No increase in muscle pain:

    Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.
    Gupta A, et al.
    Lancet. 2017.
     
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Correlation of some predisposing intrinsic conditions with the morphological integrity of the Achilles tendon.
    Fakoya AOJ et al
    Ann Afr Med. 2018 Apr-Jun;17(2):58-63. doi: 10.4103/aam.aam_49_17.
     
  22. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Achilles tendon structure is negatively correlated with body mass index, but not influenced by statin use: A cross-sectional study using ultrasound tissue characterization.
    de Sá A et al
    PLoS One. 2018 Jun 21;13(6):e0199645. doi: 10.1371/journal.pone.0199645. eCollection 2018.
     
  23. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  24. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    PUBLIC RELEASE: 7-NOV-2018
    Study explores timing of muscle-related problems of statin use

    Statins have been linked with muscle pain and other musculoskeletal adverse events (MAEs) in some patients. A new Pharmacology Research & Perspectives study has examined the timing of MAEs that develop during statin therapy and determined whether concomitant drugs used concurrently with statin therapy shifts the timing of MAEs.

    For the study, cases in which statins (atorvastatin, rosuvastatin, simvastatin, lovastatin, fluvastatin, pitavastatin, and pravastatin) were prescribed were extracted from the US Food and Drug Administration Adverse Event Reporting System Data Files.

    The onset timing of statin-induced musculoskeletal adverse events (MAEs) differed with each statin. For example, the onset of MAEs was significantly faster with high-intensity statins including atorvastatin and rosuvastatin than with simvastatin. Concomitant use of drugs--even those that may increase the risk of MAEs--did not cause changes in the onset timing of MAEs associated with statins.

    "Passive surveillance of adverse events has played a major role in securing drug safety as a system to detect unknown adverse events. Data mining using Food and Drug Administration Adverse Event Reporting System, which is a large-scale database, will be an aid to enhance drug safety," said senior author Dr. Daiuke Kobayashi, of Josai University, in Japan.
     
  25. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  26. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release – a cohort study design combined with an experimental study
    Pernilla Eliasson, Franciele Dietrich-Zagonel, Anna-Carin Lundin, Per Aspenberg, Alicja Wolk & Karl Michaëlsson
    Scientific Reports volume 9, Article number: 17958 (2019)
     
  27. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    News Release 3-Apr-2023
    Moderate exercise safe for people with muscle pain from statins
    Statins do not increase muscle injury after prolonged walking, important for heart health in statin users

    Statin therapy does not exacerbate muscle injury, pain or fatigue in people engaging in moderate-intensity exercise, such as walking, according to a study published today in the Journal of the American College of Cardiology. The findings are reassuring for people who experience muscle pain or fatigue from statins but need to engage in physical activity to keep their cholesterol levels low and their hearts healthy.

    Statins have long been the gold standard for lowering LDL or “bad” cholesterol and preventing cardiovascular disease (CVD) events, but while generally well-tolerated, they can cause muscle pain and weakness in some. Physical activity is also a cornerstone of CVD prevention, especially when combined with statins; however, studies have shown vigorous exercise can increase muscle damage in some statin users, which can lead to decreased physical activity or cause people to stop taking their medication. Less is known about the impact of moderate exercise.

    Researchers sought to compare the impact of moderate-intensity exercise on muscle injury in symptomatic and asymptomatic statin users, plus nonstatin using controls. Symptomatic vs. asymptomatic was determined by the presence, localization and onset of muscle cramps, pain and/or weakness using the statin myalgia clinical index score. Researchers also examined the association between leukocyte CoQ10 levels on muscle injury and muscle complaints, since statins may lower CoQ10 levels and reduced levels can predispose people to muscle injury.

    All study participants walked 30, 40 or 50 km (18.6, 24.8 or 31 miles, respectively) per day at a self-selected pace for four consecutive days. Statin users had all been on the medication for at least three months. The researchers excluded those with diabetes, hypo- or hyperthyroidism, known hereditary skeletal muscle defects, other diseases known to cause muscle symptoms or those using CoQ10 supplementation. There were no differences in body mass index, waist circumference, physical activity levels or vitamin D3 levels (low vitamin D3 levels have been associated with statin-induced myopathy and therefore may be a risk-factor for statin-associated muscle symptoms) among the three groups at baseline.

    Researchers found that statins did not exacerbate muscle injury or muscle symptoms after moderate-intensity exercise.

    “Even though muscle pain and fatigue scores were higher in symptomatic statin users at baseline, the increase in muscle symptoms after exercise was similar among the groups,” said Neeltje Allard, MD, first author of the study and researcher at the Department of integrative physiology, Radboud University Medical Center in Nijmegen, Netherlands. “These results demonstrate that prolonged moderate-intensity exercise is safe for statin users and can be performed by statin users to maintain a physically active lifestyle and to derive its cardiovascular health benefits.”

    Researchers did not find a correlation between leukocyte CoQ10 levels and muscle injury markers at baseline or after exercise nor was there a correlation between CoQ10 levels and muscle fatigue resistance or muscle pain scores.

    In an accompanying editorial comment, Robert Rosenson, MD, Director of Metabolism and Lipids for the Mount Sinai Health System in New York, said patients experiencing statin associated muscle symptoms will often avoid exercise because of muscle pain and weakness and concerns of making the pain worse; however, exercise is essential for restoring and maintaining fitness in people at increased risk for cardiovascular disease or who have had a cardiovascular event.

    “[Based on the study], many patients who develop statin associated muscle symptoms may engage in a moderately intensive walking program without concern for worsened muscle biomarkers or performance,” he said.
     
  28. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of Statin Treatment
    on the Development of Tendinopathy
    A Nationwide Population-Based Cohort Study

    Donghee Kwak et al
    Source
     
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