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Foam and Hydrogel dressing for diabetic foot ulcers

Discussion in 'Diabetic Foot & Wound Management' started by NewsBot, Sep 9, 2011.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    Hydrogel dressings for healing diabetic foot ulcers.
    Dumville JC, O'Meara S, Deshpande S, Speak K.
    Cochrane Database Syst Rev. 2011 Sep 7;9:CD009101.
    Foam dressings for healing diabetic foot ulcers.
    Dumville JC, Deshpande S, O'Meara S, Speak K.
    Cochrane Database Syst Rev. 2011 Sep 7;9:CD009111.
     
  2. NewsBot

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    Hydrogel dressings for healing diabetic foot ulcers.
    Dumville JC, O'Meara S, Deshpande S, Speak K.
    Cochrane Database Syst Rev. 2013 Jul 12;7:CD009101.
     
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    Treatment of infected diabetic foot ulcers clinical effectiveness of a dressing of alginate and hydrocolloid, with silver fiber. Analysis of results of a series of cases.
    Lázaro-Martínez JL, Cecilia-Matilla A, Aragón-Sánchez J, García-Morales E, Garcia-Alvarez Y, Alvaro-Afonso F.
    Rev Enferm. 2013 Nov;36(11):29-34.
     
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    PUBLIC RELEASE: 20-MAR-2018
    Hydrogel may help heal diabetic ulcers
    Tests show Rice University invention could accelerate tissue growth compared with current treatment

    HOUSTON - (March 20, 2018) - A hydrogel invented at Rice University that is adept at helping the body heal may also be particularly good at treating wounds related to diabetes.

    The Rice lab of chemist and bioengineer Jeffrey Hartgerink reported this week that tests on diabetic animal models showed the injectable hydrogel significantly accelerated wound healing compared with another hydrogel often used in clinics.
    The study appears this week in the American Chemical Society journal ACS Biomaterials Science and Engineering.
    The multidomain peptide (MDP) hydrogel known by its amino acid sequence - K2(SL)6K2 - has in a recent study proven useful for the timed release of immunotherapy drugs. It has also been shown to encourage healing all by itself.
    That quality may be useful for people with diabetes mellitus who often develop chronic wounds in their lower extremities that take longer to heal than normal wounds.

    "This is particularly exciting because the study shows our material has an effect that's positive and better than things that are already out there," Hartgerink said. "This has been a long time coming."

    He said the typical treatment for a diabetic foot ulcer has not changed much over the last century.

    "The current gold standard of treatment is to debride the wound, which means to remove necrotic tissue. The wound is washed, bandaged and patients are told to keep pressure off the foot," said Nicole Carrejo, a Rice graduate student and the paper's lead author. "Various treatments and materials may be tried, but oftentimes, everything fails, which can lead to amputation."

    The researchers reported that Rice's MDP hydrogel significantly accelerated the healing of wounds in genetically diabetic rodents. Treatment led to wound closure in 14 days, the formation of thick granulation tissue, including dense growth of blood vessels and nerve cells, and the regeneration of hair follicles.

    They compared their results with a control group treated with a commercial hydrogel that required twice as long to reach the same degree of wound closure. "Unlike our MDP hydrogel, the control hydrogel does not get infiltrated by cells," Carrejo said. "Although the control results in the healing of wounds, we believe cellular infiltration of our MDP helps lead to the acceleration of wound healing."

    Hartgerink hopes to move the hydrogel toward clinical trials as a material rather than a drug to ease the federal approval process. "That would make it much more practical to do a clinical trial," he said. "These preclinical experiments have been exciting enough to warrant that thought process."
     
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    Effects of Hydrogel With Enriched Sodium Alginate in Wounds of Diabetic Patients.
    Gustinelli Barbosa MA et al
    Plast Surg Nurs. 2018 Jul/Sep;38(3):133-138. doi: 10.1097/PSN.0000000000000228.
     
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    A Systematic Review and Meta-Analysis of Clinical Effectiveness and Safety of Hydrogel Dressings in the Management of Skin Wounds.
    Zhang L et al
    Front Bioeng Biotechnol. 2019 Nov 21;7:342
     
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    Effects of Hydrogel With Enriched Sodium Alginate in Wounds of Diabetic Patients
    Murilo Antonio Gustinelli Barbosa, André Oliveira Paggiaro, Viviane Fernandes de Carvalho, César Isaac, Rolf Gemperli
    Plast Surg Nurs. Apr/Jun 2020;40(2):110-115
     
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    The Promising Hydrogel Candidates for Preclinically Treating Diabetic Foot Ulcer: A Systematic Review and Meta-analysis
    Haijian Wu et al
    Adv Wound Care (New Rochelle). 2022 Mar 1
     
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    A review on wound dressings: Antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release
    EmadNaseri & AliAhmadia
    European Polymer Journal; Volume 173, 15 June 2022, 111293
     
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    Hydrogel-based Treatment Strategies to Accelerate Diabetic Foot Ulcer Healing
    Sadgi et al
    Curr Diabetes Rev. 2023 Jan 27
     
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    Scoping Review of Hydrogel Therapies in the Treatment of Diabetic Chronic Wounds
    Ayushi D. Sharma et al
    Plast Reconstr Surg Glob Open. 2023 May; 11(5): e4984.
     
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    Smart Nanofibrous Hydrogel Wound Dressings for Dynamic Infection Diagnosis and Control: Soft but Functionally Rigid
    Raj Kumar Sen et al
    ACS Appl Bio Mater. 2024 Jan 10
     
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