Amlexanox as a topical for diabetic foot ulcers

NewsBot · Dec 1, 2025

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Repurposing amlexanox as a topical anti-inflammatory and antioxidant intervention for diabetic foot ulcers: insights from in-silico and in-vivo studies
Nishika Kapoor, Navneet Dhaliwal, Jatinder Dhaliwal & Kanwaljit Chopra
Source

Background

Diabetic foot ulcers (DFUs), a debilitating manifestation of diabetes mellitus, involve persistent inflammation, oxidative stress, and impaired wound healing, largely driven by NF-κB overactivation. Amlexanox (ALX), a synthetic anti-inflammatory and antioxidant agent, was evaluated for its therapeutic potential in DFUs.
Methods

In-silico molecular docking and pharmacokinetic studies were conducted to predict ALX’s interactions with major DFU targets and to assess its topical suitability. STZ-induced diabetic rats with full-thickness foot ulcers (5 mm) received topical ALX (2.5% and 5%) or silver sulfadiazine ointments for 14 days. Wound closure, antioxidant enzymes, oxidative stress markers, connective tissue markers, pro-inflammatory markers and NF-κB expression were assessed in the wound tissue.
Results

ALX demonstrated strong binding to the pathological targets (NF-κB, MMP-9, MPO, and COX-2) and displayed a favourable PK profile. Moreover, ALX topical treatment did not normalise diabetic metabolic alterations, but it dose-dependently promoted wound healing. Indeed, ALX 5% significantly accelerated wound closure (p < 0.0001) and led to marked suppression of NF-κB and MMP-9 expression (p < 0.0001). It also enhanced the levels of connective tissue markers, including hexosamine (p < 0.001), hydroxyproline, and hexuronic acid (p < 0.0001). Robust anti-inflammatory effects were also observed, as ALX reduced IL-1β, IL-6, TNF-α levels and COX-2 activity (p < 0.0001). Furthermore, ALX 5% diminished oxidative stress by lowering LPO, PCO, and MPO levels (p < 0.0001), and restoring GSH levels and SOD and CAT (p < 0.001) activities indicating its anti-oxidant properties.
Conclusion

Taken together, the present work highlights the mechanisms associated with ALX mediated wound healing in diabetic rats thereby demonstrating its potential as a promising strategy for DFU management.
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NewsBot · Dec 1, 2025

From ChatGPT:
Amlexanox is a medication best known for treating aphthous ulcers, commonly called canker sores.
Here’s a clear rundown:
What it is

Amlexanox is an anti-inflammatory and anti-allergic drug. It doesn't numb pain directly; instead, it reduces the inflammatory response that makes ulcers hurt and take longer to heal.
How it’s used

Usually found as a 5% topical paste applied directly to mouth ulcers.

Helps shorten healing time and reduce pain when used early in the ulcer’s development.

How it works

It inhibits the release of inflammatory mediators—mainly histamines and leukotrienes—which slows down the cycle of irritation and swelling.
Other research uses

Although not common in daily clinical practice, amlexanox has been studied for:

Obesity and type 2 diabetes (experimental; related to inflammation pathways)

Allergic conditions (older research)

NewsBot · Dec 1, 2025

From Wikipedia:

Amlexanox

Chemical compound

Pharmaceutical compound

Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. This drug has been discontinued in the U.S.^[1]

^ "Amlexanox (Aphthasol®)". Archived from the original on 20 November 2013. Retrieved 20 November 2013.

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Amlexanox as a topical for diabetic foot ulcers

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Amlexanox

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Share This Page

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