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Bilateral Foot Pain in a Child With Crouzon Syndrome

Discussion in 'Pediatrics' started by NewsBot, May 11, 2023.

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  1. NewsBot

    NewsBot The Admin that posts the news.

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    Mysterious Bilateral Foot Pain in a Child With Crouzon Syndrome
    Kyle Coombes et al
    Cureus. 2023 Apr 1;15(4):e36999
     
  2. NewsBot

    NewsBot The Admin that posts the news.

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    Crouzon syndrome

    Crouzon syndrome is an autosomal dominant genetic disorder known as a branchial arch syndrome. Specifically, this syndrome affects the first branchial (or pharyngeal) arch, which is the precursor of the maxilla and mandible. Because the branchial arches are important developmental features in a growing embryo, disturbances in their development create lasting and widespread effects. The syndrome is caused by a mutation in a gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2).

    Crouzon syndrome is named for Octave Crouzon,[1][2] a French physician who first described this disorder. First called "craniofacial dysostosis" ("craniofacial" refers to the skull and face, and "dysostosis" refers to malformation of bone), the disorder was characterized by a number of clinical features which can be described by the rudimentary meanings of its former name. The developing fetus's skull and facial bones fuse early or are unable to expand. Thus, normal bone growth cannot occur. Fusion of different sutures leads to abnormal patterns of growth of the skull.

    1. ^ synd/1383 at Who Named It?
    2. ^ L. E. O. Crouzon. Dysostose cranio-faciale héréditaire. Bulletin de la Société des Médecins des Hôpitaux de Paris, 1912, 33: 545-555.
     
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