Welcome to the Podiatry Arena forums

You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members, upload content, view attachments, receive a weekly email update of new discussions, access other special features. Registered users do not get displayed the advertisements in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!

  1. Everything that you are ever going to want to know about running shoes: Running Shoes Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
  2. Have you considered the Critical Thinking and Skeptical Boot Camp, for taking it to the next level? See here for more.
    Dismiss Notice
  3. Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
Dismiss Notice
Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
Dismiss Notice
Have you liked us on Facebook to get our updates? Please do. Click here for our Facebook page.
Dismiss Notice
Do you get the weekly newsletter that Podiatry Arena sends out to update everybody? If not, click here to organise this.

Ciclopirox for the treatment of onychomycosis

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Jun 9, 2010.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

    Members do not see these Ads. Sign Up.
    Ciclopirox nail lacquer for the treatment of onychomycosis: an open non-comparative study.
    Shemer A, Nathansohn N, Trau H, Amichai B, Grunwald MH.
    J Dermatol. 2010 Feb;37(2):137-9.
     
  2. Graham

    Graham RIP

    It's 36% successful in mild to moderate cases:

    In other words it doesn't work (well)!

    Has to be applied 2-3/week for 48 months!

    Have fun!
     
  3. The standard treatment course for ciclopirox is daily treatment for 9-12 months, not 48 months. Most patients show good improvement in nail appearance in my clinical experience. 67% of patients showed mild improvement to complete cure in this study which is about what I have gotten in my patients. Down the street from me, a podiatrist charges $1200.00 for "laser fungal toenail treatment" using a non-FDA approved laser and no peer-reviewed scientific studies to back up his amazing claims of "curing nail fungus".

    Graham, I am interested....what do you tell your patients you can do for their mycotic nails.....other than trimming them?
     
  4. Heres a new peer review study for laser.
     
  5. zsuzsanna

    zsuzsanna Active Member

    Very interesting article but the results are less impressive than I thought. It seems to be an expensive option for a possible cure.
    I still prefer the Terbinafine tablets, or if that is not possible the Amorolfine varnish which is applied twice a week, not every day.
     
  6. medisrch

    medisrch Active Member

    36% success rate? Not as good as I would have expected but I have had good results with Phytonail over many years. Much cheaper too.
     
  7. zsuzsanna

    zsuzsanna Active Member

    I have not found Phytonail any good for my patients. But then I am not there to supervise its use.
    Zsuzsanna
     
  8. mariannam

    mariannam Welcome New Poster

    Since I can't read the whole article can anyone please confirm that the suggested use of ciclopirox in the study is with or without deep nail debridement?

    I find that the combination of the two (ciclopirox and debridement) has more than 66% success rate (complete resolution of infection) in my patients given they are reviewed every 4-8 weeks.
     
  9. medisrch

    medisrch Active Member

    Surprised to hear this. Used in my clinic for years with excellent results. Is the patient applying twice daily for four weeks and then once on retiring?
     
  10. Tim VS

    Tim VS Active Member

    Is this available in the UK, and if so, is it POM or general sale?

    Thanks,

    Tim
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Onychomycosis does not always require systemic treatment for cure: a trial using topical therapy.
    Pediatr Dermatol. 2013 May-Jun;30(3):316-22.
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    A multicenter, randomized, open-label, controlled study comparing the efficacy, safety and cost-effectiveness of a sequential therapy with RV4104A ointment, ciclopiroxolamine cream and ciclopirox film-forming solution with amorolfine nail lacquer alone in dermatophytic onychomycosis.
    Paul C, Coustou D, Lahfa M, Bulai-Livideanu C, Doss N, Mokthar I, Turki H, Nouira R, Fazaa B, Ben Osman A, Zourabichvili O, Cazeau C, Coubetergues H, Picot S, Bienvenu AL, Voisard JJ.
    Dermatology. 2013;227(2):157-64.
     
  13. blinda

    blinda MVP

    Hmm, so the amorolfine group did not receive mechanical debridemnet, (imperative for efficacy) nor chemical avulsion...

    The jury is still out on whether ciclopirox is classified as fungistatic or fungicidal. Sure, it demonstrates fungistatic behaviour in vitro and in treatment for tinea versicolour - which is a yeast, not a dermatophyte! So, it`s efficacy in treatment for T-rubrum, the most frequent fungus found in OM is questionable, IMO.
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.
    Tauber A et al
    Mol Pharm. 2014 Jul 7;11(7):1991-6
     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Comparison of user-friendliness and treatment cost of Loceryl vs. Ciclopoli--a patient's perspective.
    Schaller M et al
    Mycoses. 2015 Oct;58(10):632-6.
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
    Schaller M et al
    Mycoses. 2017 Dec;60(12):800-807.
     
Loading...

Share This Page