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Genetic risk factors for posterior tibial tendon dysfunction

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Nov 26, 2016.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

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    Posterior tibial tendinopathy associated with Matrix Metalloproteinase 13 promoter genotype and haplotype.
    de Araujo Munhoz FB et al
    J Gene Med. 2016 Nov 25. doi: 10.1002/jgm.2934.
     
  2. Admin2

    Admin2 Administrator Staff Member

  3. Dieter Fellner

    Dieter Fellner Well-Known Member

    I always enjoy reading about the hereditary disposition for a foot complaint but always struggle to know what to Rx to address the deficiency. Oh well.... it makes for a good stocking filler when talking to a patient about matrix metalloproteases, polymorphisms and alleles....
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Does MMP-3 polymorphism have a role in the etiology of the posterior tibial tendinopathy?
    A.L. Godoy-Santos et al
    Fuß & Sprunggelenk; 12 March 2017
     
  5. Craig Payne

    Craig Payne Moderator

    Articles:
    6
    Reading the full text, they wrongly used the term "tendinopathy" - it was about "dysfunction"
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen III and V in posterior tibial tendinopathy.
    Diniz-Fernandes T et al
    Histol Histopathol. 2018 Mar 13:11982. doi: 10.14670/HH-11-982.
     
  7. Craig Payne

    Craig Payne Moderator

    Articles:
    6
    Reading the full text, they wrongly used the term "tendinopathy" - it was about "dysfunction"
     
  8. Dieter Fellner

    Dieter Fellner Well-Known Member

    I don't have access but will hazard a guess the 'dysfunction' is a consequence of the tendinopathy. The authors evaluate identifiable gene polymorphism and variations between control v disease group. In any event, it's of little consequence to the management protocol. Somewhat like hallux valgus and familial / genetic tendency. Makes for an educated discussion with a patient but it's a 'so what'. Too late to change your parents.
     
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