Welcome to the Podiatry Arena forums

You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members, upload content, view attachments, receive a weekly email update of new discussions, access other special features. Registered users do not get displayed the advertisements in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!

  1. Everything that you are ever going to want to know about running shoes: Running Shoes Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
  2. Have you considered the Critical Thinking and Skeptical Boot Camp, for taking it to the next level? See here for more.
    Dismiss Notice
  3. Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
    Dismiss Notice
Dismiss Notice
Have you considered the Clinical Biomechanics Boot Camp Online, for taking it to the next level? See here for more.
Dismiss Notice
Have you liked us on Facebook to get our updates? Please do. Click here for our Facebook page.
Dismiss Notice
Do you get the weekly newsletter that Podiatry Arena sends out to update everybody? If not, click here to organise this.

Glucosamine / Chondroitin in Osteoarthritis - the definitive study

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Feb 7, 2006.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

    Members do not see these Ads. Sign Up.
    This is late news (Nov last year), but the boss thought its still worth posting as it was quite a noteworthy study:

    Press release from the American College of Rheumatology:
    GLUCOSAMINE AND CHONDROITIN SULFATE MAY BE USEFUL FOR PATIENTS WITH MODERATE TO SEVERE PAIN FROM KNEE OSTEOARTHRITIS
    Here is the conference abstract:
    The Efficacy of Glucosamine and Chondroitin Sulfate in Patients with Painful Knee Osteoarthritis (OA): The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)

    Daniel O. Clegg 1, Domenic J. Reda 2, Crystal L. Harris 3, Marguerite A. Klein 4, for the GAIT Investigators. 1 University of Utah, Salt Lake City, UT; 2 VACSP, Hines, IL; 3 VACSP, Albuquerque, NM; 4 NCCAM/NIH, Bethesda, MD

     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    glucosamine and chondroitin sulfate

    Here is a different take on the same study just released from Associated Press:
    Study: Supplements Fail to Ease Arthritis
    February 23, 2006 02:00:33 AM PST
     
  3. Elizabeth

    Elizabeth Member

    For what its worth. Glucosamine (bought from the pet shop) is the only things that is keeping my elderly German Shepherd dog on her feet. If we stop giving it to her she starts falling around with her legs giving in. A few hours after recommencing she was walking again.
     
  4. Podiatry777

    Podiatry777 Active Member

    I have some patients swear by it, others ask me if its helpful. From the above study I stil don't know much about it. Drugs are complex issue as even the medical profession knows little and trusts what ever is going...

    millionairs in drug industry can fudge studies as much as they wish- I'll trust a healthy preventative Orgainc diet before I'll trust a drug study, sorry. Exercise for healthy joints, too ofcourse. The rest you just accommodate with orthotic devices which I understand alot more about how they actually function.
     
  5. trudi powell

    trudi powell Active Member

    I swear by it !!

    Yes it takes a good 3 weeks or more to be effective and to help nourish the cartiledge but wow ! does it help my knees !!

    But you get what you pay for, don't buy the bargain basement brands, get the good ones from the health food store.
     
  6. Footsies

    Footsies Active Member

    Does anyone know what an effective dose would be? I have heard 1000mg a day?
     
  7. trudi powell

    trudi powell Active Member

    Generally the dose is 1000mg of the glucosamine component. Some high potency tablets are made 1500mg and again some patients have been advised to take 2000mg.

    Then there is the dosage / price per tablet . Some are 1 a day and others can be 2 at each meal. I like the 1 a day option.

    Be aware there is glucosamine sulfate and glucosamine hydrochloride. Obviously people allergic to sulfonamides won't want to take the sulfate one.
    And... most forms are derived from shark cartiledge, so no good for those allergic to seafoods.

    But quiz the health food store or do a google and find out more.
     
  8. musmed

    musmed Active Member

    Hold your horses, Nelly.

    Glucosamine is made from glucose and an amine added. That is amonia less a hydrogen atom. It occurs in everyone and as far as I know everthing mammalian.

    The big debate lies in the stabilising group, ie. sulphate vs. the hydrorochloride.

    If ones looks at all the papers, the hydrochloride comes a distant second on the asorbance scale. It is chraper but the studies show it to have a more random absorbance 11-78% versus a 80+ with the sulphate.

    I have never read that a sulphate group is resopnsible for a sulphite (read allergy) group. Different kettle of fish, but willing to learn.

    AS for dose, 1500 mg per day is the only dose. Anymore or any less is useless, taken for a minimum of three months, or possibly 6 months, before saying it is no good.

    For added results add the shark cartilage.

    Remember this is for the knee.

    There should be major data withn three months on all other joints in a study for people with OA.

    I must add that the GOD's speak for pain relief, but 30% of all people with OA have NO Pain!

    Who knows those who experince a dramatic relief (taking the pills) are not going through one of those periods when the pain is better (central Control)/(burn out as in rheumatoid arthritis)/ versus actual benefits of the pills.

    Having said that, there is MRI evidence that the combined pill taking makes the body attempt to make new cartilage in the knee.

    musmed
    www.musmed.com.au
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Role of glucosamine in osteoarthritis
    R. Thakral, U.K. Debnath and C. Dent
    Current Orthopaedics
    Volume 21, Issue 5, October 2007, Pages 386-389

     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of Glucosamine Sulfate on Hip Osteoarthritis
    A Randomized Trial

    Annals of Internal medicine 19 February 2008 | Volume 148 Issue 4 | Pages 268-277
     
  11. drsarbes

    drsarbes Well-Known Member

    Am I to understand that 30% of your patients w/ OA of the knee who are taking 1500 mg G/C combination have NO PAIN?

    With all due respect (if this is what you are saying) I find this very unlikely.
    I would be very willing to go on record as saying that there is no treatment out there that renders 30% of patients suffering from OS of the knee total pain relief.



    Steve
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
    Allen D Sawitzke et al
    Ann Rheum Dis doi:10.1136/ard.2009.120469
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
    Simon Wandel, Peter Jüni,Britta Tendal, Eveline Nüesch, Peter M Villiger, Nicky J Welton, Stephan Reichenbach, Sven Trelle
    BMJ 2010; 341:c4675
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    The Joints on Glucosamine (Jog) Study: The Effect of Oral Glucosamine on Joint Structure, A Randomized Trial
    C. Kent Kwoh, Frank W. Roemer, Michael J. Hannon, Carolyn E. Moore, John M. Jakicic, Ali Guermazi, Stephanie M. Green, Rhobert W. Evans and Robert Boudreau,
    Arthritis & Rheumatology, DOI: 10.1002/art.38314, published online 11 March 2014.
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    In a Two-Year Double-Blind Randomized Controlled Multicenter Study, Chondroitin Sulfate Was Significantly Superior to Celecoxib at Reducing Cartilage Loss with Similar Efficacy at Reducing Disease Symptoms in Knee Osteoarthritis Patients
    Jean-Pierre Pelletier et al
    2015 ACR/ARHP Annual Meeting
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of chondroitin sulphate on synovitis of knee osteoarthritic patients
    Laura Tío et al
    Medicina Clínica; 27 February 2017
     
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    New Evidence for Chondroitin

     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Learned Since the Glucosamine/chondroitin Arthritis Intervention Trial
    Nicholas DiNubile, MD
    Orthopedics. https://doi.org/10.3928/01477447-20180511-06
     
Loading...

Share This Page