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How to Walk Without Pain

Discussion in 'General Issues and Discussion Forum' started by rmallia, May 29, 2013.

  1. rmallia

    rmallia Member

    Abstract
    The aim of this study was to evaluate, for the first time, the antifungal efficacy of nanocapsules and nanoemulsions containing Melaleuca alternifolia essential oil (tea tree oil) in an onychomycosis model. The antifungal activity of nanostructured formulations was evaluated against Trichophyton rubrum in two different in vitro models of dermatophyte nail infection. First, nail powder was infected with T. rubrum in a 96-well plate and then treated with the formulations. After 7 and 14 days, cell viability was verified. The plate counts for the samples were 2.37, 1.45 and 1.0 log CFU mL(-1) (emulsion, nanoemulsion containing tea tree oil and nanocapsules containing tea tree oil, respectively). A second model employed nails fragments which were infected with the microorganism and treated with the formulations. The diameter of fungal colony was measured. The areas obtained were 2.88 ± 2.08 mm(2), 14.59 ± 2.01 mm(2), 40.98 ± 2.76 mm(2) and 38.72 ± 1.22 mm(2) for the nanocapsules containing tea tree oil, nanoemulsion containing tea tree oil, emulsion and untreated nail, respectively. Nail infection models demonstrated the ability of the formulations to reduce T. rubrum growth, with the inclusion of oil in nanocapsules being most efficient.


    I don't think they are talking about head lice in this article. As far as anecdotal data vs empirical evidence there is a fine line but when the n reaches into the thousands it seems more empirical. You should know, the knowledge of the empire.
     
  2. Craig Payne

    Craig Payne Moderator

    Articles:
    8
    Thats an in vitro study. All the in vivo studies on the foot show it does not work.
     
  3. Exactly thus. You know what else kills t rubrum in a dish? Bleach. Also phenol or an oxyacetaline torch. That does not make those things either safe or effective to use on people.

    That's why we do in vivo trials.
     
  4. drsha

    drsha Banned

    Ian:

    I differ. Your method doesn't what I would call scientific inspection.

    You need to do more in order to form a scientific opinion of new material.

    What page did you pick for functional foot typing?

    Dennis
     
  5. Griff

    Griff Moderator

    Taking tips on the scientific method/critical analysis from you Dennis?

    I'd rather take tips on how to masturbate from Edward Scissorhands...
     
  6. drsha

    drsha Banned

    Ian:
    All I said was I differ.

    I can do that can't I?
    Dennis
     
  7. W J Liggins

    W J Liggins Well-Known Member


    Admin. When is the next quote of the year competition? This is my nomination.

    Bill Liggins
     
  8. I didn't even know that Mr. Griffiths had it in him.....must be hanging out too much with Dr. Spooner........:rolleyes:
     
  9. David Wedemeyer

    David Wedemeyer Well-Known Member

    Classic Ian, still laughing and yes quote of the year entry

    Dennis brings out the very best in all of us Kevin :empathy:
     
  10. rmallia

    rmallia Member

    From:
    nt J Dermatol. 2012 Sep 24. doi: 10.1111/j.1365-4632.2012.05654.x. [Epub ahead of print]
    A review of applications of tea tree oil in dermatology.
    Pazyar N, Yaghoobi R, Bagherani N, Kazerouni A.
    Source
    Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Abstract
    Tea tree oil (TTO) is an essential oil, steam-distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen-4-ol and a maximum content of 1, 8-cineole. Terpinen-4-ol is a major TTO component which exhibits strong antimicrobial and anti-inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad-spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa. Several studies have suggested the uses of TTO for the treatment of acne vulgaris, seborrheic dermatitis, and chronic gingivitis. It also accelerates the wound healing process and exhibits anti-skin cancer activity. This review opens up new horizons for dermatologists in the use of this herbal agent.
    © 2012 The International Society of Dermatology.


    Antifungal activity
    Tea tree oil is able to kill candida in vitro.25 A doubleblinded
    randomized controlled trial (RCT) with 25% and
    50% TTO showed a marked clinical response to TTO in
    the treatment of interdigital tinea pedis.26 Additionally, it has been demonstrated that 2% butenafine hydrochloride
    and 5% TTO cure 80% of patients with toenail
    onychomycosis with no occurrence of relapse.27 In
    another multicenter RCT, patients with distal subungual
    onychomycosis were treated with 100% topical TTO
    for six months. This therapy resulted in improved nail
    appearance and symptomatology.28 Tea tree oil is also
    active against Madueralla mycetomatis in vitro and can
    be a useful agent in the treatment of eumycetoma because
    the prime component of TTO can easily penetrate the
    skin.29

    Antiviral activity
    Schnitzler et al.22 demonstrated that TTO has potent
    virucidal activity against herpes simplex virus 1 (HSV-1)
    and HSV-2 and affects the virus before or during adsorption,
    not after penetration into the host cell. Additionally,
    a randomized, placebo-controlled trial demonstrated that
    TTO may be a potentially cheaper alternative for the
    treatment of recurrent herpes labialis. It is acceptable to
    patients and possesses little threat of inducing resistance
    to systemic antiviral agents.23 Tea tree oil has been
    shown to be efficient in the treatment of hand warts
    caused by human papillomavirus (HPV), facilitating the
    complete re-epithelialization of infected areas.24

    Antibacterial activity
    Terpinen-4-ol is a potent agent against methicillinresistant
    Staphylococcus aureus (MRSA) and coagulasenegative
    staphylococcus (CoNS). A study showed that
    TTO used at a 10% concentration has effects comparable
    with those of topical mupirocin against the bacterium
    S. aureus. At this concentration, no resistance has been
    detected; however, it can occur at lower percentages.18 In
    addition, washing with 5% TTO is effective in removing
    MRSA from the skin.19
    The introduction of a solubilizer to a system containing
    TTO leads to a substantial increase in the bacteriostatic
    activity of the TTO. A combination of 0.5% TTO, 5%
    solubilizer, and 0.3% synthetic preservative ensures the
    microbiologic stability of soft body balm in accordance
    with American European Pharmacopoeia (AEP) criteria.20
    Tea tree oil is also effective against oral bacteria. Mouth
    washing with TTO reduces the amount of plaque that
    develops in the oral cavity.21

    Wound healing
    There is evidence for the influence of essential oils
    in wound healing and their potential application in
    clinical practice.43 Tea tree oil hydrogel seems to be
    effective in cooling burn wounds and increasing the
    rate of wound healing in both immediate and delayed
    applications.44

    Safe and Effective according to Department of Dermatology,
    Jundishapur University of Medical
    Sciences, Ahvaz, Iran
    Correspondence
    Nader Pazyar, MD
    Department of Dermatology
    Imam Khomeini Hospital
    Azadegan Street
    Ahvaz 6193673166
    Iran
    E-mail: dr.pazyar@gmail.com
     
  11. blinda

    blinda MVP

    Last post. Repetition is dull.

    You still haven`t provided references for evidence of `anti-fungal activity` in vivo trials. Moreover, nowhere in your last post does it state that TTO is safe or effective for dermatophyte infection of onychomycosis.

    Craigs` earlier comments apply equally;

    To go back to my original point; you stated that TTO is "very safe", which is in direct contradiction to all the evidence.http://raizando.com.br/artigos ciên...fety, efficacy and provenance of tea tree.pdf

    With regard to effectiveness, as you yourself stated in your ebook; "The efficacy of these medications is not considered very high."Which is absolutley correct, as concluded in the above link;

    I have not disputed the fact that TTO does have some antimicrobial properties, that is NOT my greatest concern. As I said here;

    http://pubs.acs.org/doi/abs/10.1021/tx200486f
    Taken from the above link;
    Like it or not, Richard. TTO is a well documented substance for causing contact dermatitis, unlike many of the trialled and tested anti-fungal topical treatments which are the only products that responsible practitioners should recommend.
     
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