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Leptin and diabetic foot ulcers

Discussion in 'Diabetic Foot & Wound Management' started by NewsBot, Sep 19, 2012.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Expression of leptin and its long-form receptor in the marginal cutaneous tissues of diabetic foot ulcers.
    Cao Y, Gao F, Li CZ, Xue YM.
    Acta Diabetol. 2012 Sep 18.
     
  2. Admin2

    Admin2 Administrator Staff Member

  3. Admin2

    Admin2 Administrator Staff Member

    Leptin

    Leptin (from Greek λεπτός leptos, "thin") is a hormone predominantly made by adipose cells and enterocytes in the small intestine that helps to regulate energy balance by inhibiting hunger, which in turn diminishes fat storage in adipocytes. Leptin acts on cell receptors in the arcuate nucleus of the hypothalamus.[6]

    Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its many sites of synthesis other than fat cells, and the many cell types beyond hypothalamic cells that have leptin receptors. Many of these additional functions are yet to be defined.[7][8][9][10][11][12]

    In obesity, a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes), resulting in an inability to detect satiety despite high energy stores and high levels of leptin.[13]

    1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174697 - Ensembl, May 2017
    2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059201 - Ensembl, May 2017
    3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
    4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
    5. ^ Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW (May 1997). "Crystal structure of the obese protein leptin-E100". Nature. 387 (6629): 206–09. Bibcode:1997Natur.387..206Z. doi:10.1038/387206a0. PMID 9144295.
    6. ^ Brennan AM, Mantzoros CS (2006). "Drug Insight: the role of leptin in human physiology and pathophysiology – emerging clinical applications". Nat Clin Pract Endocrinol Metab. 2 (6): 318–27. doi:10.1038/ncpendmet0196. PMID 16932309.
    7. ^ Cite error: The named reference pmid7624777 was invoked but never defined (see the help page).
    8. ^ Cite error: The named reference pmid7624778 was invoked but never defined (see the help page).
    9. ^ Cite error: The named reference pmid7624776 was invoked but never defined (see the help page).
    10. ^ Cite error: The named reference pmid7584987 was invoked but never defined (see the help page).
    11. ^ Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J, Caro JF (June 1995). "Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity". J. Clin. Invest. 95 (6): 2986–88. doi:10.1172/JCI118007. PMC 295988. PMID 7769141.
    12. ^ Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL (1996). "Serum immunoreactive-leptin concentrations in normal-weight and obese humans". N. Engl. J. Med. 334 (5): 292–95. doi:10.1056/NEJM199602013340503. PMID 8532024.
    13. ^ Pan H, Guo J, Su Z (May 2014). "Advances in understanding the interrelations between leptin resistance and obesity". Physiology & Behavior. 130: 157–69. doi:10.1016/j.physbeh.2014.04.003. PMID 24726399.
     
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