MRSA in diabetic foot ulcers

NewsBot · Jul 20, 2025

Innovative Non-antibiotic Strategies for Combating Methicillin-Resistant Staphylococcus aureus in Diabetic Foot Infections
Mohsen Nazari, Ali Bahrami & Faezeh Jahanian
Current Microbiology

Diabetic foot infections (DFIs) are a common and serious complication of diabetes mellitus (DM), often caused by methicillin-resistant Staphylococcus aureus (MRSA), which is challenging to treat due to its antibiotic resistance. The ability of MRSA to form biofilms and its resistance to commonly used antibiotics, such as beta-lactams, clindamycin, and trimethoprim–sulfamethoxazole, complicate treatment strategies. The pathophysiology of MRSA in DFIs involves bacterial virulence factors, including adhesion proteins, exotoxins, and immune evasion mechanisms, which allow MRSA to persist in infected wounds despite compromised immune responses in diabetic patients. Diabetes-related conditions such as neuropathy, poor glycemic control, and ischemia further exacerbate the susceptibility to and severity of these infections. With conventional antibiotic therapies facing increasing resistance, alternative non-antibiotic treatment options, including antimicrobial peptides, bacteriophage therapy, and nanotechnology-based interventions, are emerging as promising strategies. This review evaluates these alternative approaches, examining their potential to improve patient outcomes and combat antibiotic-resistant MRSA in DFIs.
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NewsBot · Sep 4, 2025

Epidemiology, Risk Factors, and External Validation of Predictive Models for Multidrug-Resistant Bacterial Infections in Diabetic Foot Ulcers
Xiangheng Dai et al
Infect Drug Resist. 2025 Aug 28:18:4471-4483.

Objective: This study aimed to investigate the epidemiological characteristics and risk factors of multidrug-resistant bacterial (MDRB) infections in diabetic foot ulcer (DFU) and externally validate existing predictive models for MDRB, Pseudomonas aeruginosa (PSA), and methicillin-resistant Staphylococcus aureus (MRSA) infections.

Methods: A retrospective analysis of 344 patients diagnosed with DFU identified key clinical and laboratory variables associated with outcomes. Univariate and multivariate logistic regression identified risk factors, while receiver operating characteristic (ROC) curves and calibration analyses assessed model validity.

Results: MDRB infections were linked to longer hospitalization, lower hemoglobin, higher hs-CRP, and higher osteoporosis prevalence. Significant risk factors included prolonged hospitalization, osteomyelitis, osteoporosis, prior antimicrobial use, and respiratory rate. PSA infections correlated with myocardial infarction and peripheral vascular disease, while no significant risk factors were identified for MRSA. External validation showed poor discriminatory ability (AUC: 0.501 for MDRB, 0.505 for PSA, 0.569 for MRSA) and calibration performance, indicating poor generalizability of existing models in our cohort.

Conclusion: MDRB infections in DFUs are associated with specific clinical characteristics and risk factors. However, existing predictive models demonstrated limited utility in our dataset, emphasizing the need for model refinement and inclusion of additional risk factors. Future research should focus on improving predictive models and developing targeted antimicrobial strategies to enhance clinical outcomes in diabetic foot infections.
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NewsBot · Sep 19, 2025

Complete genome sequence of a methicillin-resistant Staphylococcus aureus strain 63-2498, isolated from a diabetic foot infection
Felise G Adams et al
Microbiol Resour Announc. 2025 Sep 19:e0057225.

Here, we report the complete genome sequence of methicillin-resistant Staphylococcus aureus 63-2498, isolated from an outpatient with a diabetic foot infection. The 2.82 Mbp genome with 2,663 predicted coding sequences was assembled using a hybrid approach combining PacBio HiFi long-read and Illumina short-read sequencing, resulting in one chromosome and three plasmids.
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NewsBot · Sep 28, 2025

Risk factors and clinical outcomes of multidrug-resistant and biofilm-producing infections in diabetic foot ulcers: a two-year cohort study
Mohd Shahid Khan et al
World J Microbiol Biotechnol. 2025 Sep 26;41(10):346.

This two-year prospective study analysed 124 diabetic foot ulcer (DFU) patients admitted to the Department of Surgery to identify clinical and microbiological predictors of multidrug-resistant (MDR) and biofilm-producing infections. The cohort was predominantly male (82.3%), with a mean age of 54.3 ± 11.6 years and a high prevalence of tobacco use (63%) and illiteracy (48.4%). Most patients (91.1%) exhibited poor glycaemic control (mean HbA1c 8.3 ± 1.3%), with neuropathy (79%) and retinopathy (72.6%) as the most common comorbidities. Ulcer severity ranged from Wagner grade 1 to 4, with 60.5% persisting for over one month. Microbiological analysis revealed 59.7% monomicrobial and 33.9% polymicrobial infections, with biofilm formation detected in 60.5% of isolates. Multivariable logistic regression showed significant associations between MDR isolates and tobacco use (OR: 4.06, P = 0.049), polymicrobial infections (OR: 20.75, P < 0.001), and biofilm formation (OR: 3.84, P = 0.033). Predictors of biofilm production included male sex (OR: 7.89, P = 0.023), neuropathy (OR: 4.44, P = 0.040), prolonged ulcer duration (OR: 0.09, P = 0.001), non-necrotic ulcers (OR: 0.16, P = 0.014), and MDR organisms (OR: 3.64, P = 0.034). Clinical outcomes included a 30.6% amputation rate (22.6% minor, 8.1% major) and an 8.9% mortality rate, with a mean hospital stay of 22.9 ± 9.2 days. These findings highlight the multifactorial nature of MDR development and biofilm-associated infections, emphasizing the critical roles of biofilm formation, polymicrobial infections, and tobacco use in DFU management. Early intervention and tailored therapies are essential to mitigate these risks and improve patient outcomes.
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MRSA in diabetic foot ulcers

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NewsBot The Admin that posts the news.

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MRSA AND DIABETIC ULCERS

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MRSA in diabetic foot ulcers

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

MRSA AND DIABETIC ULCERS

foot pain following MRSA infection

Nail surgery and MRSA screening

Medihoney, MRSA and venous ulcers

Maggots used to cure MRSA

Stop wearing neck ties to help combat MRSA

MRSA

Share This Page

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