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Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Mar 18, 2020.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis.
    Chen Z et al
    Medicine (Baltimore). 2020 Mar;99(11)
     
  2. NewsBot

    NewsBot The Admin that posts the news.

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    A Study on the effects of injection of platelet rich
    plasma (Autologous) in the management of
    osteoarthritis of knee joints

    Dr. Umakant G and Dr. Krishna Naik
    International Journal of Orthopaedics Sciences 2020; 6(1): 1003-1010
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
    John W. Belk, BA, Matthew J. Kraeutler, MD, Darby A. Houck, BA, ...
    The American Journal of Sports Medicine April 17, 2020
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of hip abductor strengthening exercises in knee osteoarthritis: a randomized controlled trial
    Varah Yuenyongviwat, Siwakorn Duangmanee, Khanin Iamthanaporn, Pakjai Tuntarattanapong & Theerawit Hongnaparak
    BMC Musculoskeletal Disorders volume 21, Article number: 284 (2020)
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Can radiographic patellofemoral osteoarthritis be diagnosed using clinical assessments?
    Jade M. Tan Hylton B. Menz Shannon E. Munteanu Natalie J. Collins Harvi F. Hart Joel W. Donnar Gearoid Cleary Isobel C. O'Sullivan Liam R. Maclachlan Catherine L. Derham Kay M. Crossley
    30 June 2020
     
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    NEWS RELEASE 4-SEP-2020
    Study: Why people with knee osteoarthritis experience different kinds of pain
    Altered nervous system mechanisms may account for differences in pain


    (Boston) -- Osteoarthritis is the most common form of arthritis worldwide, affecting more than 300 million people. It causes substantial pain, functional limitations, and disability in patients.

    The pain experience in patients with knee osteoarthritis changes over time. People initially experience primarily weight-bearing related pain, such as with jogging and stair-climbing. Over time, the pain becomes more persistent and can flare unpredictably.

    To better understand why this change in the pain experience occurs, researchers from the Boston University schools of Medicine (BUSM) and Public Health reviewed data from the Multicenter Osteoarthritis Study about the pain experience of 2,794 older adults with or at risk of knee osteoarthritis. They found that people with more pain sensitization were more likely to suffer from constant and unpredictable pain, rather than just intermittent pain. This study has identified for the first time a potential underlying mechanism in the nervous system responsible for why people experience varying pain patterns with knee osteoarthritis.

    "Our findings support the clinical relevance of neurobiological mechanisms that affect the pain experience in knee osteoarthritis, including not only the severity of pain, but whether the pain is intermittent or constant, and whether the pain is unpredictable," said senior author Tuhina Neogi, MD, PhD, professor of medicine and epidemiology at Boston University School of Medicine.

    By understanding the different mechanisms that contribute to the pain experience of knee osteoarthritis, healthcare providers can begin to personalize pain management to each patient. For example, if a patient has pain sensitization, therapies that can alter those nervous system signaling pathways may be helpful. This would improve the current 'one-size-fits-all' approach, in which each patient is started with the same treatment and then moved on to something else if the first approach did not work.

    "By understanding these mechanisms, determining ways to identify those mechanisms in the clinic, and developing treatments to target those mechanisms, we can provide better management options to the millions of people worldwide with osteoarthritis," said Dr. Neogi.
     
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    Treating Knee Osteoarthritis With Platelet-Rich Plasma and Hyaluronic Acid Combination Therapy: A Systematic Review
    Michael R. Baria, MD, MBA, W. Kelton Vasileff, MD, James Borchers, MD, MPH, ...
    The American Journal of Sports Medicine April 8, 2021
     
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    Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials
    Tom GH Wiggers et al
    British Journal of Sports Medicine Published Online First: 26 May 2021
     
  9. NewsBot

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    Effectiveness of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Clinical Trials
    Liu-yan Nie, MBBS, Kun Zhao, MBBS, Jiaqi Ruan, MBBS, ...
    Orthopaedic Journal of Sports Medicine March 2, 2021
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Arthroscopy Association of Canada Position Statement on Exercise for Knee Osteoarthritis: A Systematic Review of Guidelines
    Saad Masud, BSc, Brendan Sheehan, MD, Alexis Rousseau-Saine, MD, ...
    Orthopaedic Journal of Sports Medicine June 14, 2021
     
  11. NewsBot

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    Articles:
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    Relative Efficacy of Intra-articular Injections in the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-analysis
    Harsh Singh, BA, Derrick M. Knapik, MD, Evan M. Polce, BS, ...
    The American Journal of Sports Medicine August 17, 2021
     
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    NEWS RELEASE 30-AUG-2021
    Novel assessment of platelet-rich plasma treatment shows efficacy in patients with osteoarthritis
    A pilot study conducted by researchers at Baylor College of Medicine combined wearable technology and patient-reported outcomes to assess the efficacy of platelet-rich plasma (PRP) treatment in osteoarthritis (OA).

    The results, published in the journal Regenerative Medicine, showed that a single injection of leukocyte-rich/PRP in the knee joint significantly improved functional mobility, pain and quality of life after six weeks. The study supports using this combined approach to further evaluate this and other emerging biological therapies for musculoskeletal disorders in larger clinical trials.

    “OA is a leading cause of disabilities, affecting nearly 52 million Americans,” said first and corresponding author Dr. Prathap Jayaram, director of regenerative sports medicine and assistant professor in the Department of Physical Medicine and Rehabilitation and Orthopedic Surgery at Baylor. “It has been estimated that more than 80% of individuals older than 55 years have some X-ray-based evidence of the disease.”

    OA develops when the smooth cushion between bones, the cartilage, breaks down. Progressively, joints become painful, swollen and hard to move, Jayaram explained. Currently, there are no validated therapies that delay disease progression. The current standard of care is limited to the alleviation of symptoms with corticosteroids.

    “However, although steroids seem to be helpful in the short term for pain, emerging evidence has associated steroid long-term use in OA with loss of cartilage,” Jayaram said. “As OA is a whole joint disease, there is a need for developing novel therapeutic strategies that ultimately prevent and/or delay disease progression while improving functional outcomes. PRP is emerging as one of the promising candidates to treat OA that are currently being used in clinical practice.”

    Combining wearable technology and patient assessment to evaluate the treatment

    One challenge of previous studies assessing PRP therapies in OA is that treatment evaluation is based on patient-reported outcomes that subjectively assess pain or aspects of joint function, such as the time up-and-go (TUG), how quick a person gets up from a chair.

    In this study, Jayaram and colleagues incorporated wearable technology to objectively assess functional outcomes such as TUG, in addition to patient-reported outcomes to comprehensively evaluate the efficacy of PRP in knee OA (KOA).

    The prospective pilot study included 12 patients diagnosed with KOA. Each patient received one ultrasound-guided injection of PRP and function and pain were evaluate six weeks later.

    PRP is prepared from the patient’s own blood by removing the red blood cells and enriching the concentration of platelets. PRP also contains white blood cells, or leukocytes. PRPs are formulated either leucocyte-rich (LR) or leukocyte-poor. A preclinical study by Jayaram and his colleagues had previously shown that LR-PRP had potential disease-modifying effects that correlated with functional outcomes.

    “In the current study, we found that a single injection of LR-PRP into the knee does significantly improve functional mobility, pain and quality of life at six weeks,” Jayaram said. “To our knowledge, our study is the first to report the efficacy of LR-PRP on objective functional outcomes using wearable sensor technology and validated patient-reported outcomes. Our findings provide the basis to conduct larger randomized clinical trials of PRP.”
     
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    Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes
    Srihatach Ngarmukos, Chotetawan Tanavalee, Chavarin Amarase, Suphattra Phakham, Warayapa Mingsiritham, Rangsima Reantragoon, Nitigorn Leearamwat, Thidarat Kongkaew, Kittipan Tharakhet, Sittisak Honsawek, Sinsuda Dechsupa & Aree Tanavalee
    Scientific Reports volume 11, Article number: 23603 (2021)
     
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    Leukocyte-Rich versus Leukocyte-Poor Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis
    A Alessandro Di Martino, MD, Angelo Boffa, MD, Luca Andriolo, MD, ...
    The American Journal of Sports Medicine February 1, 2022
     
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    The Effectiveness of Nerve Growth Factor (NGF) Monoclonal
    Antibody for the Treatment of Knee Osteoarthritis

    Thu Phu, B.S.
    Extremitas
     
  17. NewsBot

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    Articles:
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    Clinical Safety and Effectiveness of Adipose-Derived Stromal Cell vs Stromal Vascular Fraction Injection for Treatment of Knee Osteoarthritis: 2-Year Results of Parallel Single-Arm Trials
    Naomasa Yokota, MD, Stephen Lyman, PhD, Hiroto Hanai, MD, PhD, ...
    The American Journal of Sports Medicine July 14, 2022
     
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    The Surgical Treatment of Osteoarthritis
    Peter Brumat et al
    Life (Basel). 2022 Jun 30;12(7):982.
     
  19. NewsBot

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    Does land-based exercise-therapy improve physical activity in people with knee osteoarthritis? A systematic review with meta-analyses
    Bell Ec et al
    Osteoarthritis Cartilage. 2022 Aug 12
     
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