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Methotrexate and infection

Discussion in 'Diabetic Foot & Wound Management' started by Kenva, Sep 3, 2007.

  1. Kenva

    Kenva Active Member


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    hi,

    We have in our diabetic foot clinic a patient (male, 82 yo)who is treated for a pressure wound on the lateral side of the foot (5th met head). we did offloading and local woundcare, gave shoe advise, ... but the problem now seems to be that every time he takes Methotrexate, the infection seems to be getting worse again. Is it possible that infections get worse by taking Methotrexate? Has anyone come across this problem before?

    Thanks

    Ken
     
  2. George F

    George F Member

    methotrexate is an immunosuppressant
     
  3. DaVinci

    DaVinci Well-Known Member

    I would be surprised if it did not get worse while on it.
     
  4. toughspiders

    toughspiders Active Member

    Yup, i believe it lowers the amount of wbc's hence making infection more likely,
    I may be worth discussing with the rheumatologist
    Bexs
     
  5. John Spina

    John Spina Active Member

    Why is this patient on methotrexate?And yes,it is an immunosuppressant.
     
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