The diabetic foot literature

NewsBot · May 19, 2014

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Where Art Thou Diabetic Foot Disease Literature? A Bibliometric Inquiry into Publication Patterns
Christine K. Nolan, DPM, Kerianne E. Spiess, DPM, Andrew J. Meyr, DPM, FACFAS
Journal of Foot and Ankle Surgery; Article in Press

The objective of the present investigation was to evaluate the published scientific data with respect to the diabetic foot. We specifically aimed to assess the quantity published and the specific location of the published reports. A standard PubMed® search was performed, and the returned abstracts were evaluated by a 2-person panel for their relevance to medical professionals working within the field of diabetic foot disease. We identified 1286 relevant studies published in 659 different journals in 2012. We also found a 6.94-fold increase in returned abstracts meeting our search criteria from January 1988 to December 2012. The results of our investigation provide unique information regarding the high volume and variety of published information pertaining to diabetic foot disease and perhaps highlights a need for multidisciplinary thinking with respect to publishing and data organization, in addition to patient care.
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NewsBot · Sep 16, 2014

Quality Randomized Clinical Trials of Topical Diabetic Foot Ulcer Healing Agents
Bolton Laura L..
Advances in Wound Care September 12, 2014

Significance: Diabetic foot ulcers (DFU) significantly add to global economic, social, and clinical burdens. Healing a DFU fast and well limits complications that can lead to lower extremity amputation, morbidity, and mortality.

Recent Advances: Many promising topical DFU healing agents have been studied in randomized clinical trials (RCT), but only one, becaplermin, has been cleared for this use by the United States Food and Drug Administration (FDA).

Critical Issues: This critical review of DFU topical healing RCTs summarizes issues identified in their design and conduct, highlighting ways to improve study quality so researchers can increase the likelihood of RCT success in propelling effective topical DFU healing agents toward clinical use. Key issues include (1) inadequate sample size, (2) risk of bias, (3) irrelevant or unreported inclusion criteria, (4) substandard outcome measures, (5) unmatched group characteristics that predict nonhealing at baseline, (6) unequal or uncontrolled concurrent interventions or standard of care, (7) heterogeneous subject or DFU samples (8) unblinded allocation, treatment, or outcome measures, or (9) inadequate follow-up for clinical relevance. These can add bias or unexplained variability to RCT outcomes, limiting clinical or statistical significance and accuracy of results.

Future Directions: This critical review summarizes ways to overcome these deficiencies to optimize DFU clinical trial design and conduct. It provides a blueprint for future excellence in RCTs testing safety and efficacy of topical DFU healing agents and smoothing the path to their clinical use.
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The diabetic foot literature

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NewsBot The Admin that posts the news.

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The diabetic foot literature

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Pravibismane for diabetic foot infections

Homeopathy for Diabetic Foot Ulcers

Diabetic Foot Influencers on Twitter

Low Plasma Arginine among Patients with Diabetic Foot Ulcer

Epalrestat is effective in treating diabetic foot infection

Targeted exercises for the diabetic foot

Pranic Healing for Diabetic Foot Ulcer Management

Share This Page

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