Cymbalta effective for peripheral neuopathy

Duloxetine

Antidepressant medication used also for treatment of anxiety and chronic pain

Not to be confused with Dapoxetine or Dulcolax.

Duloxetine, sold under the brand name Cymbalta among others,^[1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization.^[7][8] It is taken by mouth.^[7]

Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI).^[9] Similarly to SSRIs and other SNRIs, the precise mechanism for its antidepressant and anxiolytic effects is not known.^[7]

Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.^[7] Severe side effects include an increased risk of suicide, serotonin syndrome, mania, and liver problems.^[7] Antidepressant withdrawal syndrome may occur if stopped.^[7] There are concerns that use during the later part of pregnancy can harm the developing fetus.^[7]

Duloxetine was approved for medical use in the United States and in the European Union in 2004.^[5][6][7] It is available as a generic medication.^[9] In 2021, it was the 27th most commonly prescribed medication in the United States, with more than 20 million prescriptions.^[10][11]

1. ^ ^{a b} "Duloxetine". Drugs.com. Archived from the original on 29 September 2018. Retrieved 24 December 2018.
2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
3. ^ "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). 31 March 2023. Archived from the original on 3 August 2023. Retrieved 16 August 2023.
4. ^ Cite error: The named reference Cymbalta FDA label was invoked but never defined (see the help page).
5. ^ ^{a b} "Cymbalta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 20 October 2020. Retrieved 30 September 2020.
6. ^ ^{a b} Cite error: The named reference EMA-2018-EPAR was invoked but never defined (see the help page).
7. ^ ^{a b c d e f g h} "Duloxetine". Monograph. The American Society of Health-System Pharmacists. Archived from the original on 26 November 2018. Retrieved 24 December 2018.
8. ^ "Medications for OCD". International OCD Foundation. Archived from the original on 27 January 2024. Retrieved 25 February 2024.
9. ^ ^{a b} British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 364–365. ISBN 9780857113382.
10. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
11. ^ "Duloxetine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 14 January 2024.

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