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Trans-Keratin Drug Delivery for Onychomycosis

Discussion in 'General Issues and Discussion Forum' started by tweinfield, Oct 26, 2006.

  1. tweinfield

    tweinfield Welcome New Poster


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    A new topical treatment for onychomycosis, which soaks the infected nail in antifungal solution, is providing promising results. The antifungal solution is applied to a sponge and heated in a microwave for 10-15 seconds. The sponge is wrapped around the infected nail for 20 minutes, twice a day.

    The theory suggests that since keratin absorbs water, it also absorbs what is dissolved in the water. The heat is believed to provide a kinetic boost which increases the rate of absorbtion by the keratin.

    We achieved our best results by first trimming and dissolving (17% salicylic acid) as much of the nail as possible. Then we used a solution of 10 ml 1% ciclopirox and 5 ml 1% salicylic acid (shampoos or solutions) dissolved in 120 ml of warm water.

    No adverse reactions to the medications were observed. The salicylic acid does tend to dry the skin, so a topical ointment was also applied twice a day. The entire process took 3 months, however, a stronger ciclopirox solution (e.g., 8% instead of 1%) may eliminate the fungus in less time. The salicylic acid is believed to increase the absorbtion of the ciclopirox by the keratin.

    Other medications have not yet been tested (such as Bifonazole-Urea). We would be interested in receiving your comments. If you think your patients can benefit from this device, send an e-mail with your address, and I'll send you a couple. :)
     

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    Last edited: Oct 26, 2006
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