Multiple Hereditary Exostoses

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Ankle Mortise Instability in Multiple Hereditary Exostoses
M Pierce Ebaugh et al
J Foot Ankle Surg. 2022 Feb 24;

 

Hereditary multiple exostoses

Rare skeletal disorder

Medical condition

Hereditary multiple osteochondromas (HMO), also known as hereditary multiple exostoses, is a disorder characterized by the development of multiple benign osteocartilaginous masses (exostoses) in relation to the ends of long bones of the lower limbs such as the femurs and tibias and of the upper limbs such as the humeri and forearm bones. They are also known as osteochondromas. Additional sites of occurrence include on flat bones such as the pelvic bone and scapula. The distribution and number of these exostoses show a wide diversity among affected individuals. Exostoses usually present during childhood. The vast majority of affected individuals become clinically manifest by the time they reach adolescence.^[1][2] A small percentage of affected individuals are at risk for development of sarcomas as a result of malignant transformation. The incidence of hereditary multiple exostoses is around 1 in 50,000 individuals.^[3] Hereditary multiple osteochondromas is the preferred term used by the World Health Organization.

1. ^ EL-Sobky, TA; Samir, S; Atiyya, AN; Mahmoud, S; Aly, AS; Soliman, R (21 March 2018). "Current paediatric orthopaedic practice in hereditary multiple osteochondromas of the forearm: a systematic review". Sicot-J. 4: 10. doi:10.1051/sicotj/2018002. PMC 5863686. PMID 29565244.
2. ^ Makhdom, AM; Jiang, F; Hamdy, RC; Benaroch, TE; Lavigne, M; Saran, N (20 May 2014). "Hip joint osteochondroma: systematic review of the literature and report of three further cases". Advances in Orthopedics. 2014: 180254. doi:10.1155/2014/180254. PMC 4054980. PMID 24963411.
3. ^ Wuyts, W; Schmale, GA; Chansky, HA; et al. (21 November 2013). "Hereditary Multiple Osteochondromas". GeneReviews. University of Washington, Seattle. PMID 20301413. Retrieved 24 March 2018.

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