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Valaciclovir and verruca

Discussion in 'General Issues and Discussion Forum' started by paulm, Jan 19, 2011.

  1. paulm

    paulm Member


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    Hi all

    i was wondering if anyone knows of any research or had any experience in using Valaciclovir in the treatment of verruca.....my reasons for asking are....
    for the past 2 years i have been seeing a 40yr old female with plantar verruca (mosaic) left foot plantar 1st mpj right foot plantar 2nd metahead....
    The lady in question suffers with Paris-Trousseau, severe learning difficulties,epileptic, prior to her coming to see me i had a telephone conversation with her mom who explained to me her daughter had suffered these painful verrucas for approx 15yrs plus and has had numerous treatments including cryo sugery all of which had failed....i agreed to see her daughter and explained possibly the best i could hope for would be to try and make her comfortable by applying padding to her insoles to give pressure relief from the verruca and paring the verruca and applying occlusol....
    I see the lady (well i did) once every two weeks, i pared the verruca and usually applied fresh padding over the past two years.....
    just recently the lady had an epileptic fit, just after this she had a skin disorder that her gp thought might be Herpes or foot and mouth, the results came back negative on both accounts but the gp prescribed Valacidlovir 500mg 10 tablets to be taken twice a day.....within two weeks the verruca have gone...i questioned the use of Valacidlovir as its a viral med but was told that no way could this be responsible for the verrucas to go, i just wondered if anyone out there had any experience of this med on verruca...
    many thanks
    Paul
     
  2. blinda

    blinda MVP

    Interesting. Valaciclovir is classified as a pro-drug. Once inside the body it is broken down into the anti-viral ingredient acyclovir (used in tx of herpes). This is a potent inhibitor of viral DNA polymerase. In other words, it stops viruses from reproducing and infecting more cells in the body. This control of the infection helps the immune system to deal with it. So it`s not unreasonable to assume it played a part in the resolution of your patients VPs.

    You may find the following study of interest;

    http://www.ncbi.nlm.nih.gov/pubmed/16390407

    Cidofovir is also an anti-viral which prevents viral replication by selective inhibition of viral DNA polymerase. Different mode of action to valaciclovir, but you get the drift....

    Cheers,
    Bel
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Topical cidofovir for plantar warts
    Laura Padilla España Javier del Boz, Teresa Fernández Morano, Javier Arenas Villafranca, Magdalena de Troya Martín
    Dermatologic Therapy; Early View
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Oral Acyclovir in the Treatment of Verruca.
    Bagwell A, Loy A, McFarland MS, Tessmer-Neubauer A.
    J Drugs Dermatol. 2016 Feb 1;15(2):237-8.
     
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