Anti-fungal cream vs powder

NewsBot · Dec 2, 2018

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EFFICACY OF ANTIFUNGAL CREAM VERSUS POWDER
IN THE TREATMENT OF FUNGAL FOOT SKIN
INFECTION AND UNPLEASANT FOOT ODOR AT
MEDICAL DEPARTMENT OF THAI NAVAL RATING
SCHOOL
Punyawee Ongsri et al
Southeast Asian J Trop Med Public Health

Tinea pedis is a common infection among military personnel. We retrospectively
reviewed the medical records of patients, clinically diagnosed with
tinea pedis at the Thai naval rating school medical department during August –
September 2015 to compare the efficacy of treating tinea pedis with clotrimazole
cream, clotrimazole powder and a combination of boric acid and salicylic acid in
a foot powder (mBS foot powder) among military personnel by evaluating clinical
improvement and improvement in foot odor. Patients were followed-up at 1 and 3
months using a Total Tinea Pedis Score (TTPS) and self-assessment ordinal score for
foot odor and sweat. A total of 120 subjects were included in the study. Thirty-five,
42 and 43 subjected were treated with clotrimazole cream, clotrimazole powder
and mBS foot powder, respectively. All topical antifungal treatments significantly
decreased the TTPS, foot odor score and sweat score at 1-month (p<0.001, p<0.001
and p=0.039, respectively). Regarding tinea pedis treatment at 3-month, clotrimazole
powder had a significantly higher TTPS reduction than mBS foot powder
(p=0.021). For sweat reduction, mBS foot powder had a significantly higher sweat
reduction score than clotrimazole powder and clotrimazole cream. Clotrimazole
cream, clotrimazole powder and mBS foot powder were all effective in treating
tinea pedis, reducing sweat and foot odor. Powder preparation may be appropriate
for tinea pedis in patients with hyperhidrosis or wearing occlusive foot wear.
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NewsBot · Jan 8, 2024

Management of Athlete's foot with topical Zinc Sulphate (15%) Solution versus Clotrimazole (1%) Solution
Saad D Hameed , Sarmad Y Abbood , Attaa A.Alhajji
Diyala Journal of Medicine the volume 25, Issue 2

Background: Athlete's foot (tinea pedis) is by far the commonest fungal infections of the integument in the developed world that usually begins between the toes. Multiple drugs were used for the treatment of athlete's foot and including both; topical and systemic agents.Zinc sulphate has been used as topical antifungal agent.

Objective: Comparison the efficacy of 15% zinc sulphate solution topically in the management of tinea pedis with topical clotrimazole solution.

Patients and Methods: A therapeutic, single blind, comparative, study of Zinc Sulphate solution (15%) in the management of tinea pedis in comparison with clotrimazole solution (both topically), that conducted in the Unit of Dermatology and Venereology ,Baquba Teaching Hospital, extended from March 2020- July 2021 . Fifty patients, 31 males and 19 females with tinea pedis were registered in this study. Divided to 2 groups of patients included in the study:

Group A: Use the topical zinc sulphate solution 15%.

Group B: Use the topical 1% Clotrimazole solution.

A complete history with examination clinically were done for all patients with tinea pedis involving all the relevant points. All patients were used the medicine twice daily for 30 days, and follow there to be seen every 14 days during the course of treatment and then follow up for two months. The patients were examined clinically; also the scoring of feet odor was done at each visit.

Results: Group A: Twenty five patients 9 (36%) females and 16 (64%) males were included in this group were treated by Zinc Sulphate solution , and their ages ranged between 27-73(47.8±12.18) years. and the duration of that illness was ranged from 1-120(43±46.61) months. Clinical response after one month of the treatment was 10(40%) patients with complete clearance, 5(20%) patients had partial clearance while 10(40%) patients showed no response.

Group B: Twenty five patients treated by clotrimazole solution, and their ages ranged from 24-65(43.2±11.83) years, and the duration of the illness was ranged from 1-180(30.24±44.9) months. Clinical response after four weeks of treatment was 19(76%) patients with complete response, 2(8%) patients had partial response, while 4(16%) patients have no response.

There was no statistical significance difference at two weeks in comparison between group A and B (chi square 5.37 P value =0.07) but was slightly significant at four weeks (chi square 6.65, P value =0.04). Side effects of treatment were mild which included itching and burning sensation in 4(16%) patients of group A and in 1(4%) patients of group B. These side effects did not require discontinuation of the treatment.

Conclusion: Clotrimazole solution was superior to15% Zinc sulphate solution as effective as topical treatment for Athlete's foot.
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