Artificial Skin System Can Heal Wounds, Research Suggests

NewsBot · Dec 21, 2007

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Artificial Skin System Can Heal Wounds, Research Suggests

A new study tested the effects of a wound dressing created with hair follicular cells. The findings reveal that skin substitutes using living hair cells can increase wound healing.

Researchers applied the technique to wound surfaces on mice. Subjects that were administered this biological dressing produced two times better wound closure than the control set.

The technique not only provides the proper environment for cell attachment and growth, but also serves as an effective biodressing to keep wounds moist and maintain structural strength during healing.

“This technique shows promise as a biological dressing that is not only efficient and strong but also can be produced with less time and effort,” says Jung Chul Kim, lead author of the study.

The use of skin substitutes for wound healing has suffered setbacks in recent years due to the expensive price. However, this method of wound dressing improves early-stage wound healing and reduces the time between preparation and patient use.
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NewsBot · Dec 21, 2007

Effect of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofiber Matrices Cocultured With Hair Follicular Epithelial and Dermal Cells for Biological Wound Dressing
Insook Han, Kyung Jin Shim, Jung Yong Kim, Sang Uk Im, Young Kwan Sung, Moonkyu Kim, Inn-Kyu Kang, Jung Chul Kim
Artificial Organs 31 (11), 801–808.

We tested the effects on the early-stage wound healing of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber matrices cultured with hair follicular cells. PHBV only, PHBV/collagen, and PHBV/gelatin at a 7/3 weight ratio were produced by electrospinning, and their in vitro cell culture and in vivo wound healing as biological dressings were examined. In cell attachment and growth on matrices, dermal sheath (DS) cells attached to hydrophilic PHBV/collagen and PHBV/gelatin faster than hydrophobic PHBV at the early incubation stage (up to 6 h). From 6- to 24-h incubation, PHBV/collagen showed the best results in cell culture. Furthermore, PHBV/collagen cocultured for 3–5 days with DS and epithelial outer root sheath (ORS) cells expressed more extracellular materials, such as type I collagen, elastin, and α-smooth muscle actin, than cocultured PHBV with the same cells. However, there was no significant difference between PHBV and PHBV/collagen in the amounts of cytokeratin 8 expressed. Grafting of PHBV and PHBV/collagen matrices cocultured with ORS/DS cells for 3–5 days showed that PHBV promoted wound closure and re-epithelization more obviously than PHBV/collagen in both cocultured matrices and matrices alone. Cocultured matrices would heal wounds better than the corresponding matrices alone. Thus, PHBV cocultured with ORS/DS cells could be used as a cell-seeded biological dressing, thereby reducing preparation time as well as regenerating the epidermis efficiently during the early stage of wound healing.
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NewsBot · Feb 28, 2022

Dried human cultured epidermis accelerates wound healing in diabetic mouse skin defect wounds
Michiharu Sakamoto et al
Sci Rep. 2022 Feb 24;12(1):3184

Cryopreserved allogeneic cultured epidermis (CE) is used for treating second-degree burn wounds and diabetic foot ulcers; however, the need for cryopreservation limits its use. We have previously reported that CE accelerates wound healing irrespective of its viability and hypothesized that dehydrated CEs lacking living cells may act as an effective wound dressing. We prepared dried CE and investigated its morphological and physical properties and wound-healing effects and compared them with those of cryopreserved CE. Hematoxylin-eosin staining, immunostaining for basement membrane, and electron microscopy revealed that the morphologies of dried CE and cryopreserved CE were comparable and that the membrane structure was not damaged. The breaking strength, modulus of elasticity, and water permeability of dried CE were comparable with those of the cryopreserved CE. Furthermore, the levels of various active cytokines and chemokines in dried CE were comparable with those in cryopreserved CE. Dried CE applied to skin defect in diabetic mice significantly reduced the wound area and increased the new epithelium length 4 and 7 days after implantation, similar to that observed for cryopreserved CE. Consequently, dried CE had similar morphological and physical properties and wound-healing effects compared with those of cryopreserved CE and can be a physiological and versatile wound-dressing.
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