Effect of Essential Oils

NewsBot · Jan 30, 2019

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The Inhibitory Effect of Essential Oils on Rhizopus stolonifer, Trichophyton mentagrophytes, and Microsporum gypseum.
Maness LR, Zubov T
Lab Med. 2019 Jan 28

BACKGROUND:
Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth.

METHODS:
We investigated the effects of 0.5% and 1% concentrations of Rosmarinus officinalis, Cinnamomum verum, Citrus paradisi, and Capsicum annuum extracts on the growth of R. stolonifer and T. mentagrophytes. The combined effects also were determined at 0.5% concentration for these fungal species and for M. gypseum. Fungal species were grown in flasks, along with growth media, for 7, 14, and 21 days, with each species of essential oil or combination of oils and mass determined and compared to its control.

RESULTS:
Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi had overall significant inhibitory effects (P ≤.05) on R. stolonifer and T. mentagrophytes. C. annuum significantly (P ≤.05) inhibited the growth of T. mentagrophytes and enhanced that of R. stolonifer. The combination of essential oils resulted in inhibition of growth (P ≤.05) at similar percentages as R. officinalis, C. verum, and C. paradisi only.

CONCLUSION:
Essential oils such as Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi may be useful for treating opportunistic and dermatophytic fungal diseases.
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Admin2 · Jan 30, 2019

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NewsBot · Aug 3, 2022

Green natural nail polish modified with essential oils to treat onychomycosis
Maura Di Vito,Claudia Scafuro,Melinda Mariotti,Stefania Garzoli,Riccardo Torelli,Abdesselam Zhiri,Maurizio Sanguinetti,Francesca Bugli
17 July 2022

Background
Onychomycosis (OM) accounts for about 50% of nail disorders in industrialised countries. Essential oils (EOs), aromatic natural compounds, are known for their antimicrobial activity.

Objective
The aim of this work was to evaluate the antifungal efficacy of seven EOs and a commercial MIX against 10 dermatophytes responsible for OM to select the most effective ones to be included in a preventive or curative formulation based on a green natural nail polish (GNNP).

Methods
Micro-broth dilution tests in line with EUCAST guidelines and olfactory satisfaction test were performed to select the best natural compounds previously analysed by SPME coupled with GC-MS. The same method was used to evaluate the release over time of the active compounds present in the two modified-GNNPs made by adding the best natural compound selected (the C. citratus EO) and the MIX. Furthermore, to evaluate the preventive and curative activity of modified-GNNPs, ex vivo experiments on healthy or colonised nails were performed.

Results and Conclusions
Data showed that MIX-modified-GNNP had preventive activity as it inhibits the fungal growth by releasing its active ingredients for 7 days, while the OE-modified GNNP acts as a natural drug showing cytocidal activity on nails colonised by dermatophytes, but it requires two weekly applications.
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Admin2 Administrator Staff Member

NewsBot The Admin that posts the news.

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