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Has anyone used Efudex Cream on warts? What has your experience been?

 

According to drugs.com Efudex is fluorouracil and is indicated for actinic or solar keratoses and VP's are not mentioned under indications and uses:
http://www.drugs.com/pdr/Efudex_Cream.html

A Google search for "Efudex Cream warts" does return some hits about its use in combination with salyclic acid, with one site noting that it does not have FDA approval for warts.

Given all the options available for VP's and the evidence for many of them, why use an unproved and unapproved therapy?

 

Can't tell you who but I know there is a dermo in Melb using it on VP's, one of my teen age patients was having it done.
Phill

 

I have used Efudix (not Efudex)(5-fluorouracil) a couple of times with no success but don't be guided by my results. Requires script from GP. About $34- a tube. One tube is enough for the average VP. Gary Dockery and Co. are the experts on its use. It has been in use since the 1970s when a couple of studies showed it may have some benefit. Gary is doing some studies at the moment which may show more specific ways to achieve best results.

Hope that helps,

Matt

 

hi there,
I know this is a little late but in 2nd year pharm for an assignment i stumbled across 5FU cream. My younger brother had large plantar warts which were increasing in size an number. After failed attempts with cryo and sal acid combinations i mentioned it to him and off they went to the GP. The reason for mentioning it was there were about 5 smallish studies that said yes it worked, but the studies were not the best due to numbers and the way it was conducted. about 3 months after first use, with regular debridement they had all cleared up. Zinc tablets were also used as it supposedly increases immune function. Application was twice daily (off the top of my head) with sports tape over the top. It was pain free and the wart of 5 years is still gone a year down the track.

Chris

 

Hi Chris,

I have continued using Efudix over the last year or so. Success seems dependent on the type of wart virus and the depth of penetration of the Efudix. I am consistently using Efudix with Sal.acid (Wartkil) mixed together and this definitely enhances the success.

Once this method works and the warts have cleared I have never seen a regrowth, which is the same success I have found with Formalin.

Matt