Notch signaling: A possible therapeutic target and its role in diabetic foot ulcers

NewsBot · Jun 27, 2022

Members do not see these Ads. Sign Up.
Notch signaling: A possible therapeutic target and its role in diabetic foot ulcers
FarmizaBegumRaghuvirKeniTejas N.AhujaFathimaBeegumKrishnadasNandakumarRekha R.Shenoy
Diabetes & Metabolic Syndrome: Clinical Research & Reviews; Volume 16, Issue 7, July 2022, 102542

Highlights
•Diabetic Foot Ulcer is a complication of diabetes having profound socioeconomic impact.
•Notch transmembrane receptor is evolutionarily conserved and plays a role in cell proliferation.
•Notch signaling controls macrophages in healing process.
Click to expand...

Background & aim
Diabetic foot ulcers are major cause of lower limb amputations in the diabetic population. The major factors that play a role in causing the delay of the process of healing in diabetic foot ulcers broadly are decreased angiogenesis, reduced proliferation and migration of keratinocytes/fibroblasts. The typical wound healing process has four phases which are overlapping with each other thus making the healing even more complex. Hence it is essential to identify a therapeutic target that involves the regulation of the cellular factors involved in healing and helps to increase angiogenesis and can regulate all four phases accordingly.

Method
Literature review involved a search of the databases namely, PubMed, Cochrane, EMBASE, and Web of Science database. Articles were identified and retrieved that specifically dealt with Notch as a target in healing of wounds and its mechanism of action on various cells and phases of healing.

Results
Notch is a cell surface receptor which interacts with transmembrane ligands of the nearby cells and is involved in cell proliferation, differentiation, cell fate and death. It is also involved in cell-to-cell communication, cell signaling, and various phases of development. There exist four known notch genes and five ligands which interact with notch proteins. Hyperglycemia plays a role in the activation of the notch receptor thus causing the release of inflammatory mediators via macrophages. As notch can regulate macrophage-mediated inflammation it can serve as a therapeutic target for diabetic foot ulcers.

Conclusion
This review focuses on the effect of notch on various cell mediators and phases of diabetic wound healing and deals with how notch activation or inhibition can serve as a potential therapeutic target for healing diabetic foot ulcers.
Click to expand...

NewsBot The Admin that posts the news.

Share This Page