Press Release: Running too far, too fast, and too long speeds progress 'to finish line of life'
This press release was based on this Editorial: Run for your life … at a comfortable speed and not too far
James H O'Keefe, Carl J Lavie Heart (Online First)
Despite there being some questioning about the Phidippides account i.e. the distance he actually ran (which also includes the amount of running he did before the Marathon to Athens run) there is another issue to consider... the fitter/more conditioned (which includes optimal diet & hydration) the runner, the less the adverse effect.
Then there is this quote from Paul Tergat's (former marathon world record holder) book - Running To The Limit:
Hence why many serious athletes (those pushing the limit for a place/money or a time) may only do 2 - 4 a year.