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A pain model with a neuropathic somatosensory lesion - Mortońs neuroma PAIN; Article in Press
A randomized, double-blind, three-period cross-over study was performed to characterize the sensory phenotype and pain demographics in patients with Morton’s neuroma (n=27) and to explore the effect of local administration (2 mL) of placebo and lidocaine (1 and 10mg/mL) around the neuroma. Using the pain quality assessment scale (PQAS) the highest rating was seen for unpleasant pain and intensity of deep pain and the lowest for sensitive skin. Ongoing pain was reported in 32% of patients. Patients stated mild to moderate average pain and that pain only marginally interfered with sleep. QST measurements in the innervation territory showed hypo or hyperphenomena in all patients, indicating neuropathy. There was no particular QST modality that appeared specifically affected.
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