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Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24-week, double-blind, placebo-controlled study.
Emtestam L, Kaaman T, Rensfeldt K.
Mycoses. 2012 Nov;55(6):532-40.

 

I wonder if I can see this very interesting study in its entirety?

I would like to know the testing that was done to determine the presence of fungus in the distal subungual area?

Also, how many patients were evaluated in order to select the 400+ candidates? or in other words, what % of patients with clinical distal subungual dystrophy were sterile?

Dennis

 

Check your inbox, Dennis.

Good questions, you know where this is going to lead, don`t you? ;)

Bel

TBC

 

Hi,
Is this the treatment base for canesten's new fungal nail treatment kit?
And has anyone actually seen any physical effectiveness with this?
I thought it was interesting because if combined with this study I'm not sure why they are only advising trwatment for 7 weeks.

If it's proving effective it would be good to know as this treatment system is cheaper than loceryl and monetary value is a really big inhibition to treatment for a lot of my patients...

Any chance I could get that study sent through to me as well???

Thanks

Jaimee

 

No........

 

Pithy ;)

BTW, propylene glycol (which is the `penetration enhancer`) has been shown to reduce efficacy of antifungal properties when used in conjunction with recognised fungstatics, see here;
Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol

PM me your email addy.

Bel

 

From Podiatry Today:
What The Research Reveals About The Use Of Urea For The Treatment Of Onychomycosis