Ultrasonographic and thermographic screening for latent inflammation in diabetic foot callus

NewsBot · Jul 11, 2009

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Ultrasonographic and thermographic screening for latent inflammation in diabetic foot callus.
Nishide K, Nagase T, Oba M, Oe M, Ohashi Y, Iizaka S, Nakagami G, Kadowaki T, Sanada H.
Diabetes Res Clin Pract. 2009 Jul 6. [Epub ahead of print]

AIMS: Inflammation within the diabetic foot callus may be an earliest, predicting symptom of foot ulcer developing later. The purpose of this study was to identify latent inflammation within the foot callus using thermography and ultrasonography, and to investigate relationship between the inflammatory findings in callus and presence or absence of diabetes.

METHODS: This was a cross-sectional study of 60 cases with asymptomatic foot callus; the 30 diabetic patients and the 30 non-diabetic matched volunteers. Inflammation was defined using physiological imaging techniques; as skin temperature elevation in thermography and low echoic lesion in ultrasonography.

RESULTS: Sixty-three and ninety-four calli were observed in the diabetic and non-diabetic groups, respectively. The inflammation signs were detected by both of the two techniques in 10% of the calli in the diabetic group. No inflammation was noted in the non-diabetic group (p=0.014).

CONCLUSIONS: The inflammation signs presented here were specifically observed in the diabetic group. We consider that the physiological imaging techniques may be valuable screening tools for potential risk of diabetic foot ulcers.
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NewsBot · Jun 17, 2020

Skin characteristics associated with foot callus in people with diabetes: A cross-sectional study focused on Desmocollin1 in corneocytes
KahoriTsuruoka et al
Journal of Tissue Viability; 12 June 2020

Highlights
•DSC1 decomposition was suppressed in the DM group.
•Suppression of DSC1 degradation was not associated with decreased skin hydration in the DM group.
•Developing novel callus care may be needed to encourage the degradation of DSC1.
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Aim
The purpose of this study was to investigate the degradation of desmocollin-1 (DSC1), a member of the desmosomal cadherin family in patients with diabetes, as well as the factors associated with the suppression of DSC1 degradation.

Methods
This cross-sectional study included 60 cases of foot callus involving 30 patients with diabetes (DM) and 30 matched volunteers without diabetes (non-DM). DSC1 degradation in samples from debrided calluses was analysed using western blotting. Skin hydration, a factor reported to suppress DSC1 degradation, was measured using a mobile moisture device.

Results
Full-length DSC1 (approximately 100 kDa) was detected in six participants only in the DM group, and no relationship was found between the suppression of DSC1 degradation and decreased skin hydration in the DM group. There was no significant difference in skin hydration values between the DM and non-DM groups.

Conclusion
DSC1 degradation was suppressed in the DM group. There was no relationship between the suppression of DSC1 degradation and decreased skin hydration in the DM group. Current external force callus care would not be sufficient. This study highlights the need to develop novel callus care to enhance the degradation of DSC1.
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