Topical cantharidin-podophylotoxin-salicylic acid (CPS) treatment of recalcitrant plantar warts

NewsBot · Apr 14, 2016

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Safety and effectiveness of cantharidin-podophylotoxin-salicylic acid in the treatment of recalcitrant plantar warts.
Lopez Lopez et al
Dermatol Ther. 2016 Apr 12

The aim of our study was to evaluate the efficacy and safety of topical cantharidin-podophylotoxin-salicylic acid (CPS) treatment of recalcitrant plantar warts (RPW). This study was carried out in a health center in the city of A Coru?a (Spain) between January and December 2013. A total of 75 patients completed all the stages of the research process. Information related to treatment with CPS and adverse effects was abstracted from medical records. Of 93 potential patients identified, 75 had at least one follow-up visit or telephone call after treatment and were included in this study. Patients experienced an average of 5.4 visits until complete resolution of their plantar wart occurred, although CPS was not applied at every visit. Fifty-four patients required one application to eliminate the wart and 21 patients required two applications/patient. Seventy-seven percent of patients experienced blistering - an expected therapeutic side effect. All patients experienced some form of an adverse event, the most common being pain (81.3%) and significant blistering (15%). Other side effects were rare (18.7%) and included pruritus, possible mild infection, significant irritation, and bleeding. All patients reported treatment, supporting our results that CPS is a safe and efficacious treatment modality for RPW and should be considered when symptomatic infection necessitates treatment.
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NewsBot · Oct 8, 2024

Cantharidin (1%), podophyllin (5%), and salicylic acid (30%) formulation in recalcitrant plantar warts: Analysis of 48 patients
Jéssica Amo-Navarrete, Sara García-Oreja, Diego León-Herce, David Navarro-Pérez, José Luís Lázaro-Martínez, Francisco Javier Álvaro-Afonso
18 September 2024 https://doi.org/10.1002/jmv.29925

A plantar wart is a benign hyperplasia that appears on the feet due to the human papillomavirus (HPV). One method used for the treatment of recalcitrant plantar warts, those lasting over 2 years or persisting after at least two treatment attempts, is the cantharidin (1%), podophyllin (5%), and salicylic acid (30%) formulation, also known as the CPS formulation. Although this method is in use, there are few studies on it. This study's objective was to ascertain its cure rate. For this retrospective observational study, we reviewed the medical records of patients treated with the CPS formulation at a podiatric clinic specializing in plantar wart treatment. Our sample size was 48 subjects. The CPS formulation had a cure rate of 62.5%. Out of the cured patients, 86.67% (26/30) required one or two applications. There was no observable correlation (p > 0.05) between wart resolution and virus biotype, evolution time, patient's morphological and clinical attributes, location, number of warts, or preceding treatments. The CPS formulation presents a relatively high efficacy rate for treating recalcitrant HPV plantar warts. Still, additional studies are necessary to evaluate its safety and efficiency.
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Samt · Jan 2, 2025

Anyone know where UK podiatrist can purchase this (topical CPS). It appears to be the wonder treatment that nobody sells.

NewsBot · Jun 18, 2025

Effect of the combination of cantharidin-podophyllin-salicylic acid
and nitric acid in the first session for the treatment of plantar
warts.
M. Medina-Alc´antara et al
Source

Plantar warts are a skin problem of great importance due to their prevalence and their negative effects on the patient’s quality
of life. Of all the treatments used, the combination cantharidin-podophyllin-salicylic acid (CPS) has shown greater efficacy
than the others, although its combination with nitric acid has not been studied. The objective was to analyze the efficacy and
safety of the combination of CPS with nitric acid in the first session with respect to the individualized components for the
treatment of plantar warts. We analyzed the number of visits and treatment sessions, side effects and evaluated the influence
of sex, age range, comparing the combination of SCP and nitric acid in the first session versus the two treatments separately in
196 patients. There were no differences in sex, with a higher incidence in children under 15 years of age. The type of wart was
single (86.6%) with a mean size of 6.13 ± 2.91 mm and metatarsal location in 49%. The first visit CPS-nitric acid combination
resulted in a mean number of visits of 3.7±2.8, a mean of 2.5±2.9 applications and 45±23 days for lesion resolution, shorter
time compared with individualized treatments. A complete resolution was observed in 96.4% of patients treated. The majority
side effect was pain (65.5%) with low level on VAS scale (49.7%). In conclusion, the CPS-nitric acid combination was a very
high effective treatment for plantar warts with a very fast and high rate for lesions resolution
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Topical cantharidin-podophylotoxin-salicylic acid (CPS) treatment of recalcitrant plantar warts

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Topical cantharidin-podophylotoxin-salicylic acid (CPS) treatment of recalcitrant plantar warts

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Samt Member

NewsBot The Admin that posts the news.

Topical Medications for Treating Diabetic Foot Ulcers - A Systematic Review

Topical Esmolol Hydrochloride for Diabetic Foot Ulcers

Topical oxygen therapy in acute traumatic musculoskeletal wounds of the foot and ankle

ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers:

Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy

Topical tx for wound colonized with Pseudomonas.

Topical nitric‐zinc in the treatment of resistant warts

Share This Page

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