Can anyone help with a query I have re. the pathomechanics of the Charcot Foot.
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A medic recently informed me that they had found micro fractures in severe neuropathic feet with diabetes. This was thought to be a predicter of Charcot onsett but on further investigation this was not the case.
My question is what are the hormonal mediators of bone modelling and are they effected by long term diabetes? Also, can the Mechanostatic mechanism of bone modelling also be effected e.g. stress response?
The reasoning for this question is that if these mechanisms are absent in the Charcot foot and not in the non-Charcot, could we have a potential predictor?
I have tried searching for this info but due to a lack of knowledge of Biochemistry, I am floudering a bit.
Any help or comments greatfully received.
Cheers
Phil Wells
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