Genetic Risk Factors for Musculoskeletal Soft Tissue Injuries.

NewsBot · Aug 22, 2009

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Genetic Risk Factors for Musculoskeletal Soft Tissue Injuries.
Collins M, Raleigh SM.
Med Sport Sci. 2009;54:136-149.

Acute and overuse musculoskeletal soft tissues injuries are common as a result of participating in specific physical or workplace activities. Multiple risk factors, including genetic factors, are implicated in the aetiology of these injuries. Common musculoskeletal soft tissue injuries for which a genetic contribution has been proposed include the Achilles tendon in the heel, the rotator cuff tendons in the shoulder and the cruciate ligaments in the knee. Recent developments in the identification of genetic risk factors for tendon and ligament injuries will be reviewed. Sequence variants within genes that encode for several tendon and/or ligament extracellular matrix proteins have been shown to be associated with specific musculoskeletal soft tissues injuries. Variants within the TNC, COL5A1 and MMP3 genes co-segregate with chronic Achilles tendinopathy. The variant within the TNC gene also appears to co-segregate with Achilles tendon ruptures, while sequence variants within the COL1A1 and COL5A1 genes have been shown to be associated with cruciate ligament ruptures and/or shoulder dislocations. Whether these variants are directly involved in the development of these musculoskeletal soft tissue abnormalities or in strong linkage disequilibrium with actual disease-causing loci remains to be established. We proposed that genetic risk factors will in the future be included in multifactorial models developed to understand the molecular mechanisms that cause musculoskeletal soft tissue injuries or related pathology. Clinicians could eventually use these models to develop personalised training programmes to reduce the risk of injury as well as to develop treatment and rehabilitation regimens for the injured individual
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Simon Spooner · Aug 22, 2009

Blood group O is believed to increase the risk of tendon disorders, specifically achilles tendonopathy.

Griff · Oct 13, 2009

Hi Simon,

Blood group O is believed to increase the risk of tendon disorders, specifically achilles tendonopathy
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This thread is a few months old admittedly - but only just stumbled across it. Is there an article you can ping over to me or point me in the direction of regarding this please?

Thanks

Ian

Simon Spooner · Oct 13, 2009

Ian said: ↑

Hi Simon,

This thread is a few months old admittedly - but only just stumbled across it. Is there an article you can ping over to me or point me in the direction of regarding this please?

Thanks

Ian
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Ian, this is mentioned in the book: Biomechanics of Musculoskeletal Injury (1998) by Whiting and Zernicke, Human Kinetics p.171. The references they provide are:

Jozsa, L. et al. (1989) Distribution of blood groups in patients with tendon rupture. Journal of Bone and Joint Surgery, 71B, 272-274

Kujala, U.M. et al (1992) ABO blood groups and musculoskeletal injuries. Injury, 23(2), 131-133

Griff · Oct 13, 2009

Thanks Simon.

I have managed to get a copy of the Jozsa paper, but am struggling to get the Kujala paper. Found it here on Science Direct but my subscription level does not allow me access to the full version - anyone out there able to help?

Ian

Griff · Oct 20, 2009

I managed to get both of these papers eventually - attached for anyone who is interested

Ian

NewsBot · Jul 20, 2021

Genetic Variations Associated with Non-Contact Muscle Injuries in Sport: a Systematic Review
Tifanny Lim, Catalina Santiago, Helios Pareja-Galeano, Tamara Iturriaga, Alicia Sosa-Pedreschi, Noriyuki Fuku, Margarita Pérez-Ruiz, Thomas Yvert
16 July 2021 https://doi.org/10.1111/sms.14020

Introduction
Non-contact muscle injuries (NCMI) account for a large proportion of sport injuries, affecting athletes’ performance and career, team results and financial aspects. Recently, genetic factors have been attributed a role in the susceptibility of an athlete to sustain NCMI. However, data in this field are only just starting to emerge.

Objectives
To review available knowledge of genetic variations associated with sport-related NCMI.

Methods
The databases Pubmed, Scopus and Web-of-Science were searched for relevant articles published until February 2021. The records selected for review were original articles published in peer-reviewed journals describing studies that have examined NCMI-related genetic variations in adult subjects (17-60 years) practising any sport. The data extracted from the studies identified were: general information, and data on genetic polymorphisms and NCMI risk, incidence and recovery-time and/or severity.

Results
Seventeen studies examining 47 genes and 59 polymorphisms were finally included. 29 polymorphisms affecting 25 genes were found significantly associated with NCMI risk, incidence, recovery time and/or severity. These genes pertain to three functional categories: i) muscle fibre structural/contractile properties, ii) muscle repair and regeneration, or iii) muscle fibre external matrix composition and maintenance.

Conclusion
Our review confirmed the important role of genetics in NCMI. Some gene variants have practical implications such as differences of several weeks in recovery-time detected between genotypes. Knowledge in this field is still in its early stages. Future studies need to examine a wider diversity of sports and standardize their methods and outcome measures.
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Attached Files:

Distribution of blood groups in patients with tendon rupture.pdf

ABO Blood groups and musculoskeletal injuries.pdf

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