Ketanserin for difficult to heal ulcers

NewsBot · Jul 25, 2006

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Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.
J Eur Acad Dermatol Venereol. 2006 Mar;20(3):277-81

BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers.

METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two similar leg ulcers. In each subject, the two lesions were randomly assigned to be treated for 8 weeks by 2% ketanserin ointment or its unmedicated vehicle.

OBJECTIVE: assessments of the dynamics of wound healing were performed using computerized morphometry. Evaluations were performed at 2-week intervals for 8 weeks.

RESULTS: A significant decrease in relative wound area was observed on the ketanserin-treated ulcers compared with the placebo group.

CONCLUSION: Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers
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Admin2 · Jul 25, 2006

Wound management

Ketanserin has been around for a while - this is from 1989:
Double-blind placebo-controlled study with topical 2% ketanserin ointment in the treatment of venous ulcers.
Dermatologica. 1989;178(2):98-102.

Previous animal and human data have shown that ketanserin, the first specific serotonin2 antagonist, may have beneficial effects on peripheral vascular diseases and on the healing of ulcers. In this double-blind study a 2% ketanserin ointment in a polyethylene glycol base was used to treat 23 patients with venous ulcers (13 ketanserin, 10 placebo). Classical wound care measures were maintained in both groups; therefore, conventional ulcer therapy (with placebo in a polyethylene glycol base) was in reality compared with conventional ulcer treatment plus ketanserin. The most important parameter for evaluation in this study was the development of granulation tissue (first sign of successful wound healing). The evolution of granulation was significantly better with ketanserin than with placebo (p less than 0.05, Mann-Whitney U test). According to the investigator's evaluation, ketanserin showed a response in 10 out of 11 patients as opposed to 5 out of 10 placebo patients at the end of the study. This first double-blind placebo-controlled study suggests that topically applied ketanserin promotes the healing of venous ulcers.
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