Polycythemia vera presenting as toe ulceration

NewsBot · May 4, 2006

Members do not see these Ads. Sign Up.
An unusual case of toe ulceration.
Vasc Med. 2006 Feb;11(1):35-7

We describe an unusual presentation of toe ulceration in a 39-year-old otherwise healthy man. The left fifth toe was painful for several months with ulceration at the tip. The other toes appeared cyanotic and discolored. Foot pulses were normal. Laboratory testing revealed the platelet count at 1208 thousand/microliter, with hemoglobin 19.2g/dl and hematocrit 57%. The erythropoietin level was found to be markedly decreased at 1 mU/ml. The patient was given the diagnosis of polycythemia vera with iron deficiency. Phlebotomy was performed and aspirin and cytoreductive therapy with hydroxyurea was prescribed with resolution of the toe ulceration.
Click to expand...

NewsBot · Aug 16, 2013

Chronic Leg Ulceration Associated with Polycythemia Vera Responding to Ruxolitinib (Jakafi®)
Victoria K. Shanmugam, MD, MRCPemail address, Sean McNish, BS, Nawar Shara, PhD, Katherine J. Hubley, RN, CWCN, Bhaskar Kallakury, MD, David M. Dunning, MD, Christopher E. Attinger, MD, John S. Steinberg, DPM
Journal of Foot and Ankle Surgery; Article in Press

We present the case of a 63-year-old white male with bilateral chronic leg ulcers due to polycythemia vera and hydroxyurea therapy who demonstrated dramatic healing of his wounds in response to ruxolitinib (Jakafi®, Novartis), a novel Janus kinase-1 and -2 inhibitor. This patient's wound had previously been refractory to multiple surgical interventions and immunosuppression. After the initiation of ruxolitinib, the patient underwent successful split-thickness skin grafting, with resultant healing of his wounds. He was stable without prednisone and other immunosuppressant therapy and had healed at 6 months. Ruxolitinib therapy could represent a novel option for patients who develop persistent inflammatory wounds in the setting of polycythemia vera and hydroxyurea therapy.
Click to expand...

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Polycythemia vera and toe pain

Medicaid Coverage for Podiatric Care

You are not average. Neither are we!

Temporary Chiropodist/podiatrist needed for coverage

Average Newton Meters of Force from a walking and running footstep

Australia - Average Full time Salary?

Had lisfranc surgery several years ago, having a lot of pain again, no new trauma

Share This Page