PVD and Fungal infections

2whiskers1 · Apr 2, 2008

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Hi I'm looking for evidence to suggest that there is a link between PVD and tinea pedis or onychomycosis or fungal infections of the skin. I have found one journal article; The Epidemiology of onychomycosis: possible role of smoking and PAD European Academy of Dermatology and Venerology (2000) 14, 466-469 but would really appreciate if fellow members could suggest other articles of interest.
Many thanks.

Admin2 · Apr 2, 2008

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Admin2 · Apr 2, 2008

PodClaire said: ↑

I have found one journal article; The Epidemiology of onychomycosis: possible role of smoking and PAD European Academy of Dermatology and Venerology (2000) 14, 466-469 but would really appreciate if fellow members could suggest other articles of interest.
Many thanks.
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FYI:

The epidemiology of onychomycosis: possible role of smoking and peripheral arterial disease
Aditya K Gupta, Madhulika A Gupta, Richard C Summerbell, Elizabeth A Cooper, Nellie Konnikov, Douglas Albreski, Paul MacDonald, Kenneth A Harris
Journal of the European Academy of Dermatology and Venereology 14 (6) , 466–469

Background
Onychomycosis is a relatively common condition the aetiology of which appears to be multifactorial, with both genetic and acquired factors being responsible. In our clinical practice we have observed that smokers and individuals with peripheral arterial disease may have an increased prevalence of onychomycosis compared to normal individuals.

Patients and methods
Patients attending a vascular clinic in a hospital were asked about a history of smoking and peripheral arterial disease. The lower extremity was assessed for peripheral arterial disease. Material was obtained from toenails for mycological evaluation.

Results
Two hundred and fifty-four patients (male 146, female 108; age, mean ± standard error, 66.6 ± 0.8 years) were enrolled. Abnormal-appearing nails and onychomycosis were present in 49.2% and 22.4% of patients, respectively. Factors associated with onychomycosis included, increasing age (risk odds ratio [ROR] 1.05, P = 0.002), male gender (ROR 1.7, P = 0.09), smoking (packs per day) (ROR 1.9, P = 0.02) and peripheral arterial disease (ROR 4.8, P = 0.02).

Conclusions
The factors predisposing to the development of onychomycosis are multifactorial. Both smoking (number of packs of cigarettes consumed per day) and peripheral arterial disease are independent predictors of onychomycosis. Awareness of these factors may help in the prevention of onychomycosis and the optimal management of this disease.
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