Tendons – time to revisit inflammation

NewsBot · Sep 5, 2014

Members do not see these Ads. Sign Up.
Full text available from BJSM:
Tendons – time to revisit inflammation

It is currently widely accepted among clinicians that chronic tendinopathy is caused by a degenerative process devoid of inflammation. Current treatment strategies are focused on physical treatments, peritendinous or intratendinous injections of blood or blood products and interruption of painful stimuli. Results have been at best, moderately good and at worst a failure. The evidence for non-infammatory degenerative processes alone as the cause of tendinopathy is surprisingly weak. There is convincing evidence that the inflammatory response is a key component of chronic tendinopathy. Newer anti-inflammatory modalities may provide alternative potential opportunities in treating chronic tendinopathies and should be explored further.
Click to expand...

Admin2 · Sep 5, 2014

Related Threads:
Other threads tagged with overuse injury and tendon injury
Biochemical changes in achilles tendinosis
Rehabilitation of Tendinopathy
Role of the paratendineous tissues in the pathogenesis of tendinopathy
Mechanobiological Aetiopathogenesis of Tendinopathy
Genetic component to achilles tendon pathology

Craig Payne · Sep 5, 2014

The twitter hastag #Tendons2014 is worth following at the moment. Lots of tweets coming from the conference:
https://twitter.com/hashtag/Tendons2014

Admin2 · Jan 26, 2017

Inflammatory mechanisms in tendinopathy – towards translation
Neal L. Millar, George A. C. Murrell & Iain B. McInnes
Nature Reviews Rheumatology 13, 110–122 25 January 2017

Tendinopathy is a multifactorial spectrum of tendon disorders that affects different anatomical sites and is characterized by activity-related tendon pain. These disorders are common, account for a high proportion (~30%) of referrals to musculoskeletal practitioners and confer a large socioeconomic burden of disease. Our incomplete understanding of the mechanisms underpinning tendon pathophysiology continues to hamper the development of targeted therapies, which have been successful in other areas of musculoskeletal medicine. Debate remains among clinicians about the role of an inflammatory process in tendinopathy owing to a lack of clinical correlation. The advent of modern molecular techniques has highlighted the presence of immune cells and inflammatory mechanisms throughout the spectrum of tendinopathy in both animal and human models of disease. Key inflammatory mediators — such as cytokines, nitric oxide, prostaglandins and lipoxins — play crucial parts in modulating changes in the extracellular matrix within tendinopathy. Understanding the links between inflammatory mechanisms, tendon homeostasis and resolution of tendon damage will be crucial in developing novel therapeutics for human tendon disease.
Click to expand...

NewsBot · Jul 1, 2018

Trends in the theory that inflammation plays a causal role in tendinopathy: a systematic review and quantitative analysis of published reviews
Michael J Mosca, Mustafa S Rashid, Sarah J Snelling, Shona Kirtley, Andrew Jonathan Carr, Stephanie Georgina Dakin
BMJ Open Sport & Exercise Medicine 2018;4:e000332

Background/aims The contribution of inflammation to tendinopathy has been debated in the scientific literature. Several factors may contribute to this lack of clarity, including inconsistent definitions of inflammation. We hypothesised that the adoption and/or rejection of a causal link between inflammation and tendinopathy varied as a function of the ‘inflammatory component’ (eg, immune cell and molecular mediators included in published reviews).

Methods Twenty data items were collected from each review to determine conclusions about the role of inflammation in tendinopathy, specific definitions of the ‘inflammatory component,’ quality of the review and other potential correlates. Associations between correlates and a review’s conclusion about the role of inflammation in tendinopathy were tested using binomial logistic regression. The database searches retrieved 2261 unique publications: 137 fulfilled inclusion criteria after full text screenings.

Results There has been little support for an inflammatory component to tendinopathy until recently (2012–2015). Prior to 2012, the majority of published reviews did not discuss monocytes, macrophages or lymphocytes in tendinopathy; rather they focused on the lack of neutrophils, often referred to as ‘the inflammatory infiltrate’, or immune cells were not discussed. Reviews including monocytes and lymphocytes in their discussions were 5.23 times more likely to conclude inflammation was important than reviews that did not, p<0.001.

Conclusions Data collected show growing support for an inflammatory component to tendinopathy, particularly among high-quality reviews and those that used more robust definitions of inflammation. This finding may have implications for explaining dissonance in the literature regarding a causal role for inflammation in the pathogenesis of tendinopathy.
Click to expand...

NewsBot The Admin that posts the news.

Admin2 Administrator Staff Member

Craig Payne Moderator

Admin2 Administrator Staff Member

NewsBot The Admin that posts the news.

foot tendons

High-mileage running makes muscles and tendons more efficient

BPC 157 Healing for torn tendons

Structural and material properties of human foot tendons

Females have better achilles tendons

Energy Return from Tendons when Running

Relationship Between Pathologies of the Peroneal, Achilles, and Posterior Tibial Tendons

Share This Page