TENS for symptomatic diabetic peripheral neuropathy

NewsBot · Jun 16, 2010

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Effect of transcutaneous electrical nerve stimulation on symptomatic diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials
Dong-mei Jin, Yun Xu, Deng-feng Geng
Diabetes Research and Clinical Practice Volume 89, Issue 1, July 2010, Pages 10-15

Aims
To evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on diabetic peripheral neuropathy (DPN).

Methods
Randomized controlled trials (RCTs) comparing TENS with routine care, pharmacological interventions or placebo devices on patients with symptomatic DPN, were identified by electronic and manual searches. Studies were selected and available data were extracted independently by two investigators. Meta-analysis was performed by RevMan 4.2.8 software.

Results
Three RCTs involving 78 patients were included in this study. The reductions in mean pain score were significantly greater in TENS group than in placebo TENS group in 4 weeks and 6 weeks follow-up [4 weeks, SMD-5.37, 95% CI (−6.97, −3.77); 6 weeks, SMD-1.01, 95% CI (−2.01, −0.01)], but not in 12 weeks follow-up [SMD-1.65, 95% CI (−4.02, 0.73)]. TENS therapy was associated with significantly subjective improvement in overall neuropathic symptoms in 12 weeks follow-up [WMD-0.18, 95% CI (−0.32, −0.051)]. No TENS-related adverse events were registered in TENS group.

Conclusions
TENS therapy may be an effective and safe strategy in treatment of symptomatic DPN. Due to small sample and short-term treatment duration, large multi-centre RCTs are needed to further evaluate the long-term effect of TENS on DPN.
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Admin2 · Jun 16, 2010

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Other threads tagged with painful neuropathy and diabetic neuropathy

NewsBot · Oct 16, 2013

Electrical Stimulation as an Adjunctive Treatment of Painful and Sensory Diabetic Neuropathy.
Thakral G, Kim PJ, Lafontaine J, Menzies R, Najafi B, Lavery LA.
J Diabetes Sci Technol. 2013 Sep 1;7(5):1202-1209.

BACKGROUND:
The objective of this review is to evaluate the use of electrical stimulation to treat diabetic neuropathy. Application of electrical stimulation may provide a novel treatment option for large and small fiber neuropathy in persons with diabetes. Large and small nerve neuropathy alters pain, proprioception, touch perception, and motor function, which cause burning foot pain and serve as protective mechanisms from ulcerations.
METHODS:
A content search for clinical trials involving electrical stimulation, neuropathy, and diabetes was conducted through PubMed. Randomized clinical trials and prospective studies with outcome measures affecting the lower extremity function were selected for review.
RESULTS:
We identified eight studies in which electrical stimulation was used to treat diabetic neuropathy. Six studies evaluated small fiber neuropathy. Two studies evaluated patients with both small and large fiber neuropathy and reported significant improvement in vibration and monofilament testing and reduction in symptoms in the electrical stimulation treatment group. Six of the eight painful neuropathy studies identified significant improvement in symptoms. There were no studies that evaluated electrical stimulation to treated diabetic motor neuropathy, fall prevention or postural instability.
CONCLUSIONS:
Electrical stimulation may be an effective alternative and adjunctive therapy to current interventions for diabetic peripheral neuropathy.
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