Duloxetine

Antidepressant medication used also for treatment of anxiety and chronic pain

Not to be confused with Dapoxetine or Dulcolax.

Duloxetine, sold under the brand name Cymbalta among others,^[1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization.^[7][8] It is taken by mouth.^[7]

Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI).^[9] Similarly to SSRIs and other SNRIs, the precise mechanism for its antidepressant and anxiolytic effects is not known.^[7]

Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.^[7] Severe side effects include an increased risk of suicide, serotonin syndrome, mania, and liver problems.^[7] Antidepressant withdrawal syndrome may occur if stopped.^[7] There are concerns that use during the later part of pregnancy can harm the developing fetus.^[7]

Duloxetine was approved for medical use in the United States and in the European Union in 2004.^[5][6][7] It is available as a generic medication.^[9] In 2021, it was the 27th most commonly prescribed medication in the United States, with more than 20 million prescriptions.^[10][11]

1. ^ ^{a b} "Duloxetine". Drugs.com. Archived from the original on 29 September 2018. Retrieved 24 December 2018.
2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
3. ^ "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). 31 March 2023. Archived from the original on 3 August 2023. Retrieved 16 August 2023.
4. ^ Cite error: The named reference Cymbalta FDA label was invoked but never defined (see the help page).
5. ^ ^{a b} "Cymbalta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 20 October 2020. Retrieved 30 September 2020.
6. ^ ^{a b} Cite error: The named reference EMA-2018-EPAR was invoked but never defined (see the help page).
7. ^ ^{a b c d e f g h} "Duloxetine". Monograph. The American Society of Health-System Pharmacists. Archived from the original on 26 November 2018. Retrieved 24 December 2018.
8. ^ "Medications for OCD". International OCD Foundation. Archived from the original on 27 January 2024. Retrieved 25 February 2024.
9. ^ ^{a b} British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 364–365. ISBN 9780857113382.
10. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
11. ^ "Duloxetine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 14 January 2024.

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