Diabetic foot ulcers and serum fetuin-A levels

NewsBot · Aug 27, 2013

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The association between the development of diabetic foot and serum fetuin-A levels.
Ozenç S, Simsek K, Yildirim A, Arslan E, Sari S, Ince M, Sarı O, Yeşilkaya S, Aydoğan U, Yaman H, Koç B, Sağlam K.
Pol Arch Med Wewn. 2013 Aug 19.

INTRODUCTION Fetuin-A is a glycoprotein secreted from hepatocytes, which has effect on diabetes and peripheral arterial disease. However, there is no study reporting the relation between diabetic foot and fetuin-A levels.

OBJECTIVES In this study, we aimed to analyze the association between the diabetic foot development and plasma fetuin-A levels.

PATIENTS AND METHODS Following the approval of the local ethical board, 137 patients were included in the study. The patients were divided into three groups: diabetes group (n=49), diabetic foot group (n=57) and control group (n=31). For all patients, serum fetuin-A levels, C-reactive protein, magnesium, and HbA1c levels were measured. The diabetic foot wounds were classified according to Wagner classification and lower extremity arteries were evaluated with ultrasonography.

RESULTS Median fetuin-A values in patients with diabetic foot were higher than those in the diabetic patients and the difference was statistically significant. However, the hemoglobin A1c levels of both groups were not statistically significant. A positive correlation was found between Wagner classification and ultrasonography evaluation of the peripheral arteries in diabetic foot patients. In diabetic foot group, fetuin-A levels were also found to be positively correlated with ultrasonographic evaluation.

CONCLUSIONS In this study, we found that there is a positive correlation between serum fetuin-A levels and development of diabetic foot.
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Admin2 · Aug 27, 2013

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