Genetics and diabetic neuropathy

NewsBot · Oct 19, 2013

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The ε4 allele of the APOE gene is associated with more severe peripheral neuropathy in type 2 diabetic patients.
Monastiriotis C, Papanas N, Trypsianis G, Karanikola K, Veletza S, Maltezos E.
Angiology. 2013 Aug;64(6):451-5.

We examined the association between the ε4 allele of the apolipoprotein E gene and severity of peripheral neuropathy in 234 patients with type 2 diabetes mellitus (T2DM). Based on the Neuropathy Disability Score (NDS), patients were divided into group A (NDS ≤ 6: mild or no neuropathy) and group B (NDS > 6: severe neuropathy). In each group, patients were further divided into ε4 carriers and non-ε4 carriers. In multivariate analysis, a more than 5-fold increased risk of severe neuropathy was associated with ε4 carrier status (adjusted odds ratio [aOR]: 5.26, 95% confidence interval [CI]: 2.24-12.31, P = .0001). The other significant risk factors for severe neuropathy included male gender (aOR: 2.08, 95% CI: 1.05-4.14, P = .036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P = .039), and hemoglobin A1c (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In conclusion, the ε4 carrier status appears to be associated with severe peripheral neuropathy in T2DM
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Admin2 · Oct 19, 2013

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NewsBot · Jun 19, 2015

Association of adiponectin gene polymorphisms with an elevated risk of diabetic peripheral neuropathy in type 2 diabetes patients
Zhi-Yong Ji, Hai-Feng Li, Yu Lei, Yan-Wei Rao, Ming-Li Sun, Zeng-Xian Tan, Huai-Jun Liu, Gen-Dong Yao, Bo Hou
Journal of Diabetes and its Complications; Article in Press

Objective
In this study, we examined the association between two adiponectin (ADPN) gene polymorphisms, +45 T/G and +276G/T, and susceptibility to diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients.

Methods
A total of 180 T2DM patients were enrolled in this study and assigned to two groups: DPN group (n = 90) and non-DPN (NDPN) group (n = 90). In addition, 90 healthy subjects were chosen as healthy normal control (NC). The plasma level of ADPN was quantified by ELISA method and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotype analysis of the two ADPN polymorphisms, +45 T/G (rs2241766) and +276G/T (rs1501299), in all the study subjects. Statistical analysis of data was performed with SPSS version 20.0 software.

Results
Serum levels of ADPN were markedly reduced in the DPN group compared to NDPN and NC groups (all P < 0.05). The frequencies of TT, TG and GG genotypes and the T and G alleles of T45G and G276T polymorphisms in DPN group were significantly different than the NDPN group (all P < 0.05). Notably, T45G and G276T polymorphisms were associated with significantly reduced plasma levels of ADPN in DPN and NDPN groups, compared to the NC group (P < 0.001). Significant difference in ADPN plasma levels were also observed between TT, TG and GG genotypes of T45G and G276T polymorphisms. Our results indicate that the T allele in +45 T/G and +276G/T polymorphisms is correlated with an elevated risk of DPN in T2DM patients. Haplotype analysis showed that GG and GT haplotypes showed a negative relationship with DPN, while TG haplotype positively correlated with risk of DPN in T2DM patients (all P < 0.05).

Conclusion
Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level.
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