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Double-jointed adolescents at risk for joint pain
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Hypermobility is a risk factor for musculoskeletal pain in adolescence: Findings from a prospective cohort study.
Tobias JH, Deere K, Palmer S, Clark EM, Clinch J.
Arthritis Rheum. 2013 Feb 28. doi: 10.1002/art.37836.
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The relationship between benign joint hypermobility syndrome and psychological distress: a systematic review and meta-analyses
Toby O. Smith, Victoria Easton, Holly Bacon, Emma Jerman, Kate Armon, Fiona Poland and Alex J. Macgregor
Rheumatology (2013) doi: 10.1093/rheumatology/ket317 First published online: September 29, 2013 -
Use of the Gait Profile Score for the evaluation of patients with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type.
Celletti C, Galli M, Cimolin V, Castori M, Tenore N, Albertini G, Camerota F.
Res Dev Disabil. 2013 Oct 1;34(11):4280-4285.
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Signs and symptoms of foot and ankle dysfunction in children with joint hypermobility
Leslie L Nicholson, Verity Pacey, Louise Tofts, Craig Munns and Roger Adams
Journal of Foot and Ankle Research 2014, 7(Suppl 1):A61 doi:10.1186/1757-1146-7-S1-A61
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Hypermobility is related with musculoskeletal pain in Indian school-children.
Abujam B, Aggarwal A.
Clin Exp Rheumatol. 2014 Jul 1.
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Injuries and disorders among young ice skaters: relationship with generalized joint laxity and tightness
Okamura S, Wada N, Tazawa M, Sohmiya M, Ibe Y, Shimizu T, Usuda S, Shirakura K
Open Access Journal of Sports Medicine; August 2014 Volume 2014:5 Pages 191—195
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The influence of joint hypermobility on functional movement control in an elite netball population: A preliminary cohort study
Kessie Soper, Jane V. Simmonds (Dr), Hanadi Kaz Kaz (Dr), Nelly Ninis (Dr)
Physical Therapy in Sport; Articles in Press
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Foot Type Analysis Based on Electronic Pedobarography Data in Individuals with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type During Upright Standing.
Veronica Cimolin, Manuela Galli, Claudia Celletti, Massimiliano Pau, Marco Castori, Gianfranco Morico, Giorgio Albertini, and Filippo Camerota
Journal of the American Podiatric Medical Association: November 2014, Vol. 104, No. 6, pp. 588-593.
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The Effect of Hypermobility on the Incidence of Injury in Professional Football: A multi-site cohort study
Ian Graham et al
Physical Therapy in Sport; Article in Press
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Muscle strength differences in healthy young adults with and without generalized joint hypermobility: a cross-sectional study
Pranay JindalEmail author, Amitesh Narayan, Sailakshami Ganesan and Joy C. MacDermid
BMC Sports Science, Medicine and Rehabilitation 25 April 2016
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Development and initial validation of the Bristol Impact of Hypermobility questionnaire
S. Palmer et al
Physiotherapy; Article in Press
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Chronic Pain in a patient with Ehlers-Danlos Syndrome (hypermobility type): The role of Myofascial Trigger Point injections
Saipriya Tewari et al
Journal of Bodywork and Movement Therapies; Article in Press
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Is Joint Hypermobility Related to Foot Osteoarthritis and Symptoms?
Yvonne M. Golightly et al
2016 ACR/ARHP Annual Meeting; September 28, 2016
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Refining patterns of joint hypermobility, habitus, and orthopedic traits in joint hypermobility syndrome and Ehlers–Danlos syndrome, hypermobility type
Silvia Morlino, et al
American Journal of Medical Genetics
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Hypermobility in Adolescent Athletes: Pain, Functional Ability, Quality of Life, and Musculoskeletal Injuries
Heidi Schmidt et al
J Orthop Sports Phys Ther, Epub 15 Sep 2017. doi:10.2519/jospt.2017.7682
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Contemporary approach to joint hypermobility and related disorders
Marco Castori, Alan Hakim
Current Opinion in Pediatrics 2017 September 12
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The Beighton score as a predictor of Brighton criteria in sport and dance
Ross Armstrong et al
Phys Ther Sport
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Range of Ankle Dorsiflexion in a Group of Adults with Ligamentous Laxity.
Salomon Benhamu-Benhamu, Raquel Garcia-de-la-Peña, Gabriel Gijon-Nogueron, Maria Dolores Jimenez-Cristino, Luis M. Gordillo-Fernández, and Gabriel Dominguez-Maldonado
Journal of the American Podiatric Medical Association: May 2018, Vol. 108, No. 3, pp. 245-252.
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Physical and mechanical therapies for lower limb symptoms in children with Hypermobility Spectrum Disorder and Hypermobile Ehlers-Danlos Syndrome: a systematic review
Benjamin Peterson, Andrea Coda, Verity Pacey and Fiona Hawke
Journal of Foot and Ankle Research201811:59
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Effect of generalized ligamentous hyperlaxity related of quality of life in the foot: a case controlled study
Patricia Palomo-López et al
Revista da Associação Médica Brasileira; Sept. 2018
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Judging heel height: A new test for proprioception while standing reveals that young hypermobile children perform better than controls.
Oluwakemi Adebukola I et al
GaitPosture. 2019 Sep 23
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Correlation between benign joint hypermobility syndrome and primary focal hyperhidrosis in children: a novel concept
Vadood Javadi Parvaneh, Hoda Shahvaladi, Khosro Rahmani, Sara Javdani Yekta, Fatemeh Abdollah Gorji, Reza Shiari & Fahimeh Abdollahimajd
BMC Musculoskeletal Disorders volume 21, Article number: 268 (2020)
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Altered multi‐segment ankle and foot kinematics during gait in patients with Hypermobile Ehlers‐Danlos Syndrome/Hypermobility spectrum disorder. A case‐control study.
Stefan Vermeulen Sophie De Mits Roel De Ridder Patrick Calders Joris De Schepper Fransiska Malfait Lies Rombaut
04 December 2020 https://doi.org/10.1002/acr.24526
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Effect of resistance training on muscle properties and function in women with generalized joint hypermobility: a single-blind pragmatic randomized controlled trial
Gere Luder, Daniel Aeberli, Christine Mueller Mebes, Bettina Haupt-Bertschy, Jean-Pierre Baeyens & Martin L. Verra
BMC Sports Science, Medicine and Rehabilitation volume 13, Article number: 10 (2021)
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Joint hypermobility and musculoskeletal injuries in a university-aged population
Peter R.Reuter
Physical Therapy in Sport 24 February 2021
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Masterclass: Hypermobility and hypermobility related disorders
Jane V.SimmondsMCSP, MMACP, SFHEA, DProf, MA, PGD (Man Ther), PGCHE, B App Sc (Physio), BPE12
Musculoskeletal Science and Practice; 13 October 2021, 102465
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Assessment of lower limbs in people
with Generalized Joint Hypermobility
– preliminary report
Paulina Ewertowska et al
Advances in Rehabilitation, 2021, 35(4), 25–32
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International Perspectives on Joint Hypermobility
A Synthesis of Current Science to Guide Clinical and Research Directions
Nicholson, Leslie L. PhD et al
JCR: Journal of Clinical Rheumatology: June 3, 2022 - Volume - Issue - 10.1097/RHU.0000000000001864
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Evaluation of the Relationship between Lower Limb Hypermobility and Ankle Muscle Strength in a Paediatric Population: Protocol for a Cross Sectional Study
Carlos Martínez-Sebastián et al
Int J Environ Res Public Health. 2022 Jun 14;19(12):72649127264
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The Effects of Joint Hypermobility on Pain and
Functional Biomechanics in Adolescents with
Chronic Musculoskeletal Pain
William Black et al
Research Square
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News Release 1-Dec-2022
Having hypermobile joints can increase the risk for depression and anxiety in adolescents
A link has been found between joint hypermobility and the emergence of depression and anxiety in adolescence, according to a new study by Brighton and Sussex Medical School (BSMS) published in BMJ Open.
Researchers found that young people with joint hypermobility were more likely to have depression and anxiety, and that psychiatric symptoms were also more severe among hypermobile participants.
Dr Jessica Eccles, Clinical Senior Lecturer BSMS and MQ Arthritis Research UK Fellow and lead author said: “Many psychiatric problems, including depression and anxiety, start before the age of 25. It is therefore important to identify the factors that may increase the risk for these disorders. Being aware of the link between hypermobility and depression and anxiety means that we can work on developing appropriate and effective treatments.”
Joint hypermobility is caused by a genetic difference in our connective tissue, and because connective tissue is present everywhere in the body, it also influences our fight-or-flight nervous system. When this part of our nervous system works differently, mental health problems are more likely to develop.
The study, which was funded by the Medical Research Council and by MQ and Versus Arthritis, also found that joint hypermobility was more common in females than males. However, it was only among males that joint hypermobility at age 14 years increased the risk for depression at 18 years old.
Although joint hypermobility is associated with anxiety disorders in adults, this link has not previously been explored in a large sample of children or young people.
Lea Milligan, CEO MQ Mental Health Research, said: “MQ is very proud to have supported the ground-breaking work of Dr Eccles and her team. This study has highlighted the need for more targeted and bespoke support for hypermobile teenagers, particularly girls. The findings don’t just show the need for support for this group of individuals, but also demonstrate the importance of research that takes a whole mind, body brain approach to health and uses longitudinal studies to improve our understanding of which demographics are at higher risk of depression and anxiety. Congratulations to Jess and her team and we look forward to the next stages in this work so that we can ensure better clinical care and treatment is provided.”
Dr Neha Issar-Brown, Director of Research and Health Intelligence at Versus Arthritis, said: "Hypermobility affects one in four people in the UK. Like other musculoskeletal (MSK) conditions it can have a profound and far-reaching impact on life, causing daily pain, fatigue and often disrupted sleep.
“Previous studies in adults have shown that you are more likely to suffer from anxiety if you have hypermobility, and that the daily toll of painful symptoms can lead to depression. Dr Eccles’ research helps identify who is at risk at a young age, which will enable better, earlier, more targeted treatments to help young people live well with hypermobility, and prevent or reduce the impact of the condition later in life.”
Researchers used an existing data base from The Avon Longitudinal Study of Parents and Children (ALSPAC), which collected data from over 14,000 children and their parents or carers, and assessed them for joint hypermobility at both 14 and 18 years old, and depression and anxiety at 18. They then used statistical tests to assess the link between joint hypermobility and depression and anxiety. -
Balance training benefits chronic ankle instability with generalized joint hypermobility: a prospective cohort study
Zong-Chen Hou et al
BMC Musculoskelet Disord. 2023 Jan 27;24(1):71. doi: 10.1186/s12891-023-06179-2.
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Examination of foot sensations in children with generalized joint hypermobility
Kamile Uzun Akkaya et al
Early Hum Dev. 2023 Mar 21;180:105755
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The Impact of Podiatric Intervention on the Quality of Life and Pain in Children and Adolescents with Hypermobility
Muhammad Maarj et al
Int J Environ Res Public Health. 2023 Aug 22;20(17):6623.
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