Intralesional Vitamin D Injection for Verruca

NewsBot · May 12, 2016

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Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts.
Aktas H et al
J Cutan Med Surg. 2016 Mar-Apr;20(2):118-22

BACKGROUND:
Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts.
AIM:
To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts.
METHODS:
Twenty patients with single or multiple plantar warts were included in this study. Vitamin D(3) (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals.
RESULTS:
In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed.
CONCLUSION:
Intralesional vitamin D(3) may be an effective treatment option for warts.
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NewsBot · Aug 22, 2019

Intralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study
Wafaa M. Abd El- Magid , MD, Essam Eldein A. Nada , MD & Reem A. Mossa , M.Sc
Journal of Dermatological Treatment : 15 Aug 2019

Background: Plantar warts are common skin lesions caused by the human papilloma virus. It is characterized by presence of a horny ring of hyperkeratosis surrounding the wart, making its elimination a therapeutic challenge. Several destructive agents are available for treatment with variable success. Intralesional vitamin D3 has been reported a successful treatment of warts. Intralesional zinc sulfate has been found to be another successful therapeutic modality for wart elimination.

Objective: To compare the efficacy and safety of intralesional Vit. D3 versus zinc sulfate in treatment of plantar warts. Patients and Methods: 40 patients were included in the study. Patients were randomly assigned to either (Vit. D3 group) or (Zinc group).In (Vit. D3 group), patients received intralesional injection of 0.3ml vitamin D3[100,000 I.U (2.5 mg/ml), while (Zinc group) patients received intralesional 2% zinc sulfate. Assessment of treatment efficacy and safety was carried out by clinical examination and comparative photographic evaluation before each session and up to 3 months after the last session.

Results: 80% of Vit. D3 treated patients and 70% of zinc sulfate patients showed complete response.

Conclusion: Intralesional Vit. D3 and Zinc sulfate appear to be effective treatment modalities for plantar warts.
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NewsBot · Nov 14, 2019

Cigarette smoking reduces the efficacy of intralesional vitamin D in the treatment of warts.
El-Taweel AE et al
Dermatol Ther. 2019 Mar;32(2)

Cigarette smoking may decrease serum levels of vitamin D and reduce its efficacy. We aimed to evaluate the safety and efficacy of intralesional vitamin D in the treatment of warts and to investigate the effect of smoking on its efficacy in these cases. The study included 20 patients with verruca vulgaris and deep palmoplantar warts. The wart to be injected was cleaned by alcohol and then injected with 0.1 mL of prilocaine (20 mg/mL). 0.2 mL of vitamin D3 (7.5 mg/mL) solution was slowly injected into the base of each wart. The maximum total amount of vitamin D3 injected into a patient in one session was 7.5 mg. The injection was done at 4 weeks interval until clearance or for a maximum of two sessions. Clinical and dermoscopic follow-up of the treated and distant warts was carried out. Forty percent of the treated lesions showed complete clearance and the rate of distant wart response was 17.65%. Among different demographic and clinical variables in the studied patients, smoking and older age seemed to decrease the therapeutic response Intralesional vitamin D is effective in the treatment of warts, however, smoking and aging may reduce its efficacy.
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