Plasma homocysteine levels and diabetic foot ulceration

NewsBot · Feb 6, 2010

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Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus.
González R, Pedro T, Real JT, Martínez-Hervás S, Abellán MR, Lorente R, Priego A, Catalá M, Chaves FJ, Ascaso JF, Carmena R.
Diabetes Metab Res Rev. 2010 Feb 4. [Epub ahead of print]

BACKGROUND: To examine the association of biochemical markers of risk (plasma Hcy, microalbuminuria, lipoprotein (a)(Lp(a)) and diabetic dyslipidaemia) with the prevalence of diabetic foot ulceration in type 2 diabetic patients.

METHODS: Case/control study conducted in 198 type 2 diabetic patients. 89 patients have foot ulcers and 109 have no foot ulcers (control group), in order to establish ORs for diabetic foot ulceration. In all subjects plasma Hcy, Lp(a), total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, HbA(1c) and microalbuminuria were measured using standard procedures.

RESULTS: Plasma Hcy, microalbuminuria, HbA(1c) and apolipoprotein B levels were significantly higher in patients with foot ulceration compared with the control group. Plasma lipids, Lp(a), vitamin B12 and folic acid values were similar in both groups. In the logistic regression model, plasma Hcy (OR 1.09; 95% CI 1.04-1.69), microalbuminuria (OR 1,01; 95% CI 1.01-1.17) and HbA(1c) levels (OR 1.33; 95% CI 1.04-1.69) were independent risk factors for the presence of diabetic foot ulceration.

CONCLUSIONS: In our study, for each micromol increase in plasma Hcy levels there was a 10% increase in the risk of diabetic foot ulceration. In addition, plasma homocyteine, HbA(1c) and microalbuminuria accounted for 50% prevalence risk of diabetic foot ulceration. Further prospective studies should be conducted to confirm the association of plasma Hcy levels with the risk of foot ulceration
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Richard Masoetsa · Feb 11, 2010

A very intersting study indeed! Thanks for info

NewsBot · May 26, 2019

Predictive value of the ratio of homocysteine to serum albumin concentrations in the recurrence of diabetic foot ulcer
Jingsi An
International Journal of Diabetes in Developing Countries: 22 May 2019

Objective
To investigate the predictive value of the ratio of homocysteine to serum albumin concentrations (Hcy/Alb) in the recurrence of diabetic foot ulcer (DFU).

Methods
A total of 210 patients hospitalized due to diabetic foot disease from May 2012, to May 2017 were selected and followed up for one year. The value of Hcy/Alb in predicting the recurrence of DFU was determined using receiver operating characteristic (ROC) curve analysis.

Results
Hcy (odd ratio = 1.171; 95% confidence interval (CI) 1.101–1.246) was an independent risk factor for the recurrence of DFU. Alb (odd ratio = 0.848; 95% CI 0.792–0.908) was a protective factor for the recurrence of DFU. The area under the ROC curve of Hcy/Alb for predicting the recurrence of DFU was 0.803 (95% CI 0.742–0.864; p < 0.01). When the Hcy/Alb was set at the best cutoff value (0.37), its sensitivity in predicting the recurrence of DFU was 97.60%, and the negative predictive value was 98.93%.

Conclusions
The sensitivity and negative predictive value of Hcy/Alb in predicting the recurrence of DFU and the overall coincidence rate are high.
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Richard Masoetsa Member

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