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Expert Interview
Latest Advances in Treatment for Gout: An Expert Interview With Kenneth G. Saag, MDRead the interview
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Quality of life and posterior tibial tendon dysfunction
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Variations of the plantar tarsometatarsal ligaments
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Fyi
Other threads here on gout:
Reason for gout in more peripheral joints
Gout can affect the nose
Test your knowledge on gout -
Does anybody notice an upswing in gout cases late in the year around Christmas and New Year's?I believe this to be so,possibly due to an increase in alcohol consumption.
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gout
Its probably just not the alcohol, but the general dietary indiscretions that happen during that time of the year that would affect gout incidence then.
Found this:
"The following foods have higher levels of purines should be restricted or avoided:
Offal foods like liver, kidneys, tripe, sweetbreads and tongue.
Large amounts of red meat.
Shellfish.
Peas. lentils and beans.
Alcohol" -
Medscape have released another update on Gout:
Hyperuricemia and Gout: New Clinical Insights and Emerging Treatments (free registration required) -
Febuxostat equals allopurinol for gout
The Cleveland CLinic Journal of Medicine has a POEMS (Patient Orientated Evidence that Matters) on:
Febuxostat equals allopurinol for gout prophylaxis (pdf file)
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Gout
New full text from Medscape (free registation required):
Recent Developments in Diet and Gout
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Gout
Gout, not induced by diuretics? A case-control study from primary care
Annals of the Rheumatic Diseases 2006;65:1080-1083
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Another new story on gout
ScienceDaily are reporting:
Gout Increases Risk Of Heart Attack, According To Study
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Gout
The latest Journal of Clinical Investigation has the full text of this article available:
Gout: new insights into an old disease
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Gout
Here is Medical News Today's take on the above article:
Glimmer Of Hope For Gout Patients
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Gout
Rheumatology News are reporting:
Febuxostat Staved Off Gout Flares During 4-Year Study
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Gout
Alcohol Consumption as a Trigger of Recurrent Gout Attacks
The American Journal of Medicine
Volume 119, Issue 9 , September 2006, Pages 800.e13-800.e18
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The extreme pain of gout
Press Release:
Extreme Pain Of Gout Is Detrimental To Quality Of Life & Work , New Poll Shows11 Nov 2006
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It's The Heat And The Humidity: How Each Worsens Gout Symptoms
It's The Heat And The Humidity: How Each Worsens Gout Symptoms
13 Nov 2006
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Gout
Response to Application of Ice May Help Differentiate Between Gouty Arthritis and Other Inflammatory Arthritides. Journal of Clinical Rheumatology. 12(6):275-276, December 2006.
Schlesinger, Naomi MD
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Medscape have a new free CE (registration required) on:
Diagnosis and Management of Acute and Chronic Gout -
Are joints affected by gout also affected by osteoarthritis?
Ann Rheum Dis. 2007 Feb 6;
Roddy E, Zhang W, Doherty M
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Medscape have just published this as a CME activity: (free registration required):
Increased Coffee Consumption May Reduce Risk for Gout in Men
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Dear All
Firstly gout just does not appear by deposition of crystals of uric acid.
The pH between the joints and blood play a major role. The presence of super saturated solutions, remember growing copper sulphate crystals at school? the same principle.
A major cause is due to gut disease. Classically a stressful time, eg long surgical operation to sever chest infection can change the gut to make you wheat intolerant/gluten intolerant. So begins the gout cycle.
A patient of mine has wheat intolerance developed after a stressful period in his life. Just to eat a jellybean that contains wheat dust (common) he gets the best bout of gout you can imagine.
Worth getting them tested especially if gout starts out of the blue.
Regards
Paul Conneely
www.musmed.com.au -
Is gout associated with reduced quality of life? A case-control study
E. Roddy, W. Zhang and M. Doherty
Rheumatology 2007 46(9):1441-1444;
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That would make sense.A lot of gout patients do have such maladies as HTN,DM and the like.Plus the pain there-and the unpredictability of flareups-makes this a vexing disease indeed.
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From the latest American Family Physician:
Gout: An Update -
Medscape have just released this full text CME (free registration required)
Treatment-Failure Gout: Recent Insights and Advances in Definition, Diagnosis, and Treatment -
Press Release:
Savient Pharmaceuticals Completes Puricase Phase 3 Studies For Treatment-Failure Gout -
Genetics and gout
The polymorphism -863C/A in tumour necrosis factor- gene contributes an independent association to gout
S.-J. Chang, P.-C. Tsai, C.-J. Chen, H.-M. Lai and Y.-C. Ko
Rheumatology 2007 46(11):1662-1666
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Dietary Factors Associated with Hyperuricemia in Adults
Seminars in Arthritis and Rheumatism, Article in Press
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Medscape have just made this available (free registration required):
Update on Crystal-Induced Arthritis and Hyperuricemia From ACR 2007 -
Gout in Ambulatory Care Settings in the United States
ESWAR KRISHNAN, DOUGLAS LIENESCH, and C. KENT KWOH
J Rheumatol; First Release Feb 1 2008
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Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
Hyon K Choi, Gary Curhan
BMJ, doi:10.1136/bmj.39449.819271.BE (published 31 January 2008)
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Press Release:
Savient Reports Additional Positive Trial Data for Secondary Endpoints from Puricase(R) (pegloticase) Phase 3 Studies -
Press Release:
February 6, 2008
FDA Takes Action to Stop the Marketing of Unapproved Injectable Drugs Containing Colchicine -
Press Releases:
COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE SUMMARY OF POSITIVE OPINION*
for ADENURIC
International Nonproprietary Name (INN): febuxostat
European Medicines Agency
Pre-Authorisation Evaluation of Medicines for Human Use
EMEA recommends marketing authorisation of Ipsen’s Adenuric® (febuxostat) for the treatment of chronic hyperuricaemia in gout
Adenuric® represents the first major treatment of gout for more than forty years
Last edited: Feb 25, 2008 -
The BBC are reporting:
Gene 'linked to higher gout risk'
A reason why millions worldwide fall prey to the painful joint condition gout may have been uncovered. -
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
Nature Genetics Published online: 9 March 2008
Last edited: Mar 25, 2009 -
Press release:
Adenuric® (febuxostat) receives marketing authorisation
in the European Union
Adenuric® represents the first major treatment of chronic hyperuricemia
in gout for more than forty years -
Here's a picture of a gouty ankle I did an arthroscope on. This is fairly representative of what the entire ankle joint looked like.
It was so classic I wanted to share it with you.
SteveAttached Files:
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Long-term Cardiovascular Mortality Among Middle-aged Men With Gout
Eswar Krishnan, MD, MPH; Kenneth Svendsen, MS; James D. Neaton, PhD; Greg Grandits, MS; Lewis H. Kuller, MD; for the MRFIT Research Group
Arch Intern Med. 2008;168(10):1104-1110.
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Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial
Dr Hein JEM Janssens MD, Matthijs Janssen PhD, Eloy H van de Lisdonk PhD, Prof Piet LCM van Riel PhD and Prof Chris van Weel PhD
The Lancet Volume 371, Issue 9627, 31 May 2008-6 June 2008, Pages 1854-1860
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Press Release:
Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout
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