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The latest on gout

Discussion in 'General Issues and Discussion Forum' started by Admin2, Dec 28, 2005.

  1. ericajones80

    ericajones80 Member

    thanks for the picture
     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Volume 7, Issue 8, Page 22 (August 2008)

    Don't Be Fooled by Normal Serum Urate in Acute Gout
    Rheumatology News Volume 7, Issue 8, Page 22 (August 2008)
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Regeneron's ARCALYST(R) (rilonacept) Reduced Incidence of Gout Flares by 81 Percent in a Phase 2 Study in Gout Patients Initiating Urate-Lowering Therapy
    Proportion of patients experiencing gout flares reduced from 45.2 percent to 14.6 percent
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    The Lancet Early Online Publication, 1 October 2008
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    ScienceDaily are reporting:
    Drug Target for Gout? Gene SLC2A9 Is High-capacity Urate Transporter In Humans
    Link to story

    SLC2A9 Is a High-Capacity Urate Transporter in Humans.
    Caulfield et al.
    PLoS Medicine, 2008; 5 (10):
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Opportunities for improving medication use and monitoring in gout
    Jasvinder A Singh, James M Hodges and Steven M Asch
    Ann Rheum Dis. Published Online First
     
  7. flikwill

    flikwill Welcome New Poster

    Thanks for all the above threads. A relative has just had a severe acute attqack of gout....now I can pass on some helpful advice,
     
  8. musmed

    musmed Active Member

    Dear Flikwill

    In the past I posted a cause that is not often looked at. The cause is the development by an individual of gluten intolerance.

    This can happen any time and at any age. The intolerance changes purine metabolism and the patient gets gout for the first time in their life.
    I have seen it in a 70 year old lady after she had a hip replacement that took 5hours!

    Intolerance can develop after a 'shock' to the system. It could be after surgery, a sudden death in the family, after a chest infection.... the list goes on.

    If such an event has occurred, or they just developed gout out of the blue, it is worth investigating.

    If it is the cause and they stick to the rules, they will not get gout and they will not need medications.

    regards
    musmed
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Hyaline cartilage involvement in patients with gout and calcium pyrophosphate deposition disease. An ultrasound study
    E. Filippucci, M. Gutierrez Riveros, D. Georgescu, F. Salaffi and W. Grassi
    Osteoarthritis and Cartilage (Article in Press)
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Gout and the risk of parkinson's disease: A cohort study
    Mary De Vera, M. Mushfiqur Rahman, James Rankin, Jacek Kopec, Xiang Gao, Hyon Choi
    Arthritis Care & Research; Volume 59 Issue 11, Pages 1549 - 1554
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Medscape have just released this full text CME:
    Treating Chronic Gout: The Challenges of Lowering Serum Urate Levels
    Slides + video.
    Link (free registration required)
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:
    Arthritis Advisory Committee Recommends FDA Approval Of Febuxostat For The Treatment Of Hyperuricemia In Patients With Gout
    25 Nov 2008
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Are glucocorticoids equivalent to NSAIDs for the treatment of gout flares?
    Angelo L Gaffo and Kenneth G Saag
    Nature Clinical Practice Rheumatology; Published online: 2 December 2008
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    The seasonality and trends in the incidence and prevalence of gout in England and Wales 1994-2007
    Alex J Elliot, Kenneth W Cross and Douglas M Fleming
    Ann Rheum Dis. Published Online First: 24 November 2008.
     
  15. admin

    admin Administrator Staff Member

    Tibialis anterior tendon rupture in gout-Case report and literature review.
    Jerome JT, Varghese M, Sankaran B, Thomas S, Thirumagal S.
    Foot Ankle Surg. 2008;14(3):166-9.
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Clinical Diagnostic Criteria for Gout: Comparsion With the Gold Standard of Synovial Fluid Crystal Analysis.
    Journal of Clinical Rheumatology. 15(1):22-24, January 2009.
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Arthroscopic elimination of monosodium urate deposition of the first metatarsophalangeal joint reduces the recurrence of gout.
    Wang CC, Lien SB, Huang GS, Pan RY, Shen HC, Kuo CL, Shen PH, Lee CH.
    Arthroscopy. 2009 Feb;25(2):153-8.
     
  18. admin

    admin Administrator Staff Member

    The 'gout' of the Medici, Grand Dukes of Florence: a palaeopathological study.
    Fornaciari G, Giuffra V, Giusiani S, Fornaciari A, Villari N, Vitiello A.
    Rheumatology (Oxford). 2009 Jan 27. [Epub ahead of print]
     
  19. admin

    admin Administrator Staff Member

    Press Release:
    ULORIC® (TMX-67, febuxostat) Receives FDA Approval for
    the Chronic Management of Hyperuricemia in Patients with Gout
     
  20. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    First Acute Gout Attacks Commonly Precede Features of the Metabolic Syndrome
    Hernández-Cuevas, Claudia Berenice MD*; Roque, Lizandra Hernández MD*; Huerta-Sil, Gabriela MD*; Rojas-Serrano, Jorge MD, MSc*; Escudero, Alejandro MD†; Perez, Letícia Lino MD*; Collantes-Estevez, Eduardo MD†; Mellado, Janitzia Vázquez MD, PhD*
    Journal of Clinical Rheumatology:Volume 15(2)March 2009pp 65-67
     
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    The BBC are reporting:
    Vitamin C a 'gout preventer'
    Full story

    Vitamin C Intake and the Risk of Gout in Men
    A Prospective Study

    Hyon K. Choi, MD, DrPH; Xiang Gao, MD, PhD; Gary Curhan, MD, ScD
    Arch Intern Med. 2009;169(5):502-507.
     
  22. NewsBot

    NewsBot The Admin that posts the news.

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    Here is some revision for everybody:

    Gout

    Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.[4][5] Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours.[8] The joint at the base of the big toe is affected in about half of cases.[10] It may also result in tophi, kidney stones, or kidney damage.[4]

    Gout is due to persistently elevated levels of uric acid in the blood.[5][8] This occurs from a combination of diet, other health problems, and genetic factors.[4][5] At high levels, uric acid crystallizes and the crystals deposit in joints, tendons, and surrounding tissues, resulting in an attack of gout.[4] Gout occurs more commonly in those who regularly eat meat or seafood, drink beer, or are overweight.[4][6] Diagnosis of gout may be confirmed by the presence of crystals in the joint fluid or in a deposit outside the joint.[4] Blood uric acid levels may be normal during an attack.[4]

    Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, or colchicine improves symptoms.[4][5][11] Once the acute attack subsides, levels of uric acid can be lowered via lifestyle changes and in those with frequent attacks, allopurinol or probenecid provides long-term prevention.[8] Taking vitamin C and eating a diet high in low-fat dairy products may be preventive.[12][13]

    Gout affects about 1 to 2% of the Western population at some point in their lives.[8] It has become more common in recent decades.[4] This is believed to be due to increasing risk factors in the population, such as metabolic syndrome, longer life expectancy, and changes in diet.[8] Older males are most commonly affected.[4] Gout was historically known as "the disease of kings" or "rich man's disease".[8][14] It has been recognized at least since the time of the ancient Egyptians.[8]

    1. ^ Brookhiser, Richard (2008). Gentleman Revolutionary: Gouverneur Morris, the Rake Who Wrote the Constitution. Simon and Schuster. p. 212. ISBN 9781439104088.
    2. ^ Haslam, Fiona (1996). From Hogarth to Rowlandson : medicine in art in eighteenth-century Britain (1. publ. ed.). Liverpool: Liverpool University Press. p. 143. ISBN 9780853236405.
    3. ^ "Gout | Definition of Gout by Lexico". Lexico Dictionaries | English. Retrieved 20 October 2019.
    4. ^ a b c d e f g h i j k l m Cite error: The named reference Dalbeth2016 was invoked but never defined (see the help page).
    5. ^ a b c d e f g Hui, M; Carr, A; Cameron, S; Davenport, G; Doherty, M; Forrester, H; Jenkins, W; Jordan, KM; Mallen, CD; McDonald, TM; Nuki, G; Pywell, A; Zhang, W; Roddy, E; British Society for Rheumatology Standards, Audit and Guidelines Working, Group. (26 May 2017). "The British Society for Rheumatology Guideline for the Management of Gout". Rheumatology (Oxford, England). 56 (7): e1–e20. doi:10.1093/rheumatology/kex156. PMID 28549177.
    6. ^ a b Beyl Jr, R. N.; Hughes, L; Morgan, S (2016). "Update on Importance of Diet in Gout". The American Journal of Medicine. 129 (11): 1153–1158. doi:10.1016/j.amjmed.2016.06.040. PMID 27452679.
    7. ^ Neogi, T (July 2016). "Gout". Annals of Internal Medicine (Review). 165 (1): ITC1-16. doi:10.7326/AITC201607050. PMID 27380294.
    8. ^ a b c d e f g h i Richette P, Bardin T (January 2010). "Gout". Lancet. 375 (9711): 318–28. doi:10.1016/S0140-6736(09)60883-7. PMID 19692116.
    9. ^ Qaseem, A; Harris, RP; Forciea, MA; Clinical Guidelines Committee of the American College of, Physicians. (3 January 2017). "Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians". Annals of Internal Medicine. 166 (1): 58–68. doi:10.7326/m16-0570. PMID 27802508.
    10. ^ Schlesinger N (March 2010). "Diagnosing and treating gout: a review to aid primary care physicians". Postgrad Med. 122 (2): 157–61. doi:10.3810/pgm.2010.03.2133. PMID 20203467.
    11. ^ Shekelle, P. G; Newberry, S. J; Fitzgerald, J. D; Motala, A; O'Hanlon, C. E; Tariq, A; Okunogbe, A; Han, D; Shanman, R (2017). "Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166 (1): 37–51. doi:10.7326/M16-0461. PMID 27802478.
    12. ^ "Questions and Answers about Gout". National Institute of Arthritis and Musculoskeletal and Skin Diseases. June 2015. Archived from the original on 15 January 2016. Retrieved 2 February 2016.
    13. ^ Roddy, E; Choi, HK (May 2014). "Epidemiology of gout". Rheumatic Diseases Clinics of North America. 40 (2): 155–75. doi:10.1016/j.rdc.2014.01.001. PMC 4119792. PMID 24703341.
    14. ^ "Rich Man's Disease – definition of Rich Man's Disease in the Medical dictionary". Free Online Medical Dictionary, Thesaurus and Encyclopedia.
     
  23. NewsBot

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    Articles:
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    Gout in the Axial Skeleton
    RUKMINI M. KONATALAPALLI, PAUL J. DEMARCO, JAMES S. JELINEK, MARK MURPHEY, MICHAEL GIBSON, BRYAN JENNINGS and ARTHUR WEINSTEIN
    The Journal of Rheumatology March 1, 2009 vol. 36 no. 3 609-613
     
  24. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Gout in the Elderly - A Population Health Study.
    Hanly JG, Skedgel C, Sketris I, Cooke C, Linehan T, Thompson K, Veldhuyzen van Zanten S.
    J Rheumatol. 2009 Mar 13. [Epub ahead of print]
     
  25. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Clinical Efficacy and Safety of Successful Longterm Urate Lowering with Febuxostat or Allopurinol in Subjects with Gout.
    Becker MA, Schumacher HR, Macdonald PA, Lloyd E, Lademacher C.
    J Rheumatol. 2009 Mar 13. [Epub ahead of print]
     
  26. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout.
    Chao J, Terkeltaub R.
    Curr Rheumatol Rep. 2009 Apr;11(2):135-40
     
  27. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Perceptions of disease and health-related quality of life among patients with gout.
    Lee SJ, Hirsch JD, Terkeltaub R, Khanna D, Singh JA, Sarkin A, Kavanaugh A.
    Rheumatology (Oxford). 2009 Mar 23. [Epub ahead of print]
     
  28. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    Press Release:

    Regeneron Announces Initiation of Phase 3 Gout Program with ARCALYST® (rilonacept)
     
  29. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Adherence with urate-lowering therapies for the treatment of gout.
    Harrold LR, Andrade SE, Briesacher BA, Raebel MA, Fouayzi H, Yood RA, Ockene IS.
    Arthritis Res Ther. 2009 Mar 27;11(2):R46. [Epub ahead of print]
     
  30. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Toward a valid definition of gout flare: Results of consensus exercises using delphi methodology and cognitive mapping.
    Taylor WJ, Shewchuk R, Saag KG, Schumacher HR Jr, Singh JA, Grainger R, Edwards NL, Bardin T, Waltrip RW, Simon LS, Burgos-Vargas R.
    Arthritis Rheum. 2009 Mar 30;61(4):535-543. [Epub ahead of print]
     
  31. NewsBot

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    Articles:
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    Quality of Life and Disability in Patients with Treatment-Failure Gout.
    Becker MA, Schumacher HR, Benjamin KL, Gorevic P, Greenwald M, Fessel J, Edwards L, Kawata AK, Frank L, Waltrip R, Maroli A, Huang B, Sundy J.
    J Rheumatol. 2009 Mar 30. [Epub ahead of print]
     
  32. NewsBot

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    Articles:
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    Effect of acute gouty arthritis on sleep patterns: a preclinical study.
    Guevara-López U, Ayala-Guerrero F, Covarrubias-Gómez A, López-Muñoz FJ, Torres-González R.
    Eur J Pain. 2009 Feb;13(2):146-53.
     
  33. NewsBot

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    Impact of noncompliance with urate-lowering drug on serum urate and gout-related healthcare costs: administrative claims analysis
    Halpern R, Mody RR, Fuldeore MJ, Patel PA, Mikuls TR.
    Curr Med Res Opin. 2009 Jun 2. [Epub ahead of print]
     
  34. twinkletoes

    twinkletoes Member

    Re: New Drugs

    i'm not actually using this but it seemed the most relevant place to put this ... has any one heard of autumn crocus for the treatment of gout?
     
  35. NewsBot

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    Press Release:
    Information for Healthcare Professionals: New Safety Information for Colchicine (marketed as Colcrys)
     
  36. NewsBot

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    Articles:
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    Press Release:
    Gout treatment fails to win approval
     
  37. NewsBot

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    Articles:
    1
    An analysis of MRI and ultrasound imaging in patients with gout who have normal plain radiographs.
    Carter JD, Kedar RP, Anderson SR, Osorio AH, Albritton NL, Gnanashanmugam S, Valeriano J, Vasey FB, Ricca LR.
    Rheumatology (Oxford). 2009 Sep 10. [Epub ahead of print]
     
  38. NewsBot

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    Articles:
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    Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis.
    Yoo HG, Lee SI, Chae HJ, Park SJ, Lee YC, Yoo WH.
    Rheumatol Int. 2009 Dec 20. [Epub ahead of print]
     
  39. NewsBot

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    Articles:
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    Pegloticase for chronic gout.
    Anderson A, Singh JA.
    Cochrane Database Syst Rev. 2010 Mar 17;3:CD008335.
     
  40. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
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    The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
    Becker MA, Schumacher HR, Espinoza LR, Wells AF, Macdonald P, Lloyd E, Lademacher C.
    Arthritis Res Ther. 2010 Apr 6;12(2):R63. [Epub ahead of print]
     
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