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Chronical treatment with sildenafil causes Achilles tendinopathy in rats
Petrus PiresMarquesaCristiano PedrozoVieirabLetícia Pradode OliveiracEdson RosaPimentelcFlávia Da RéGuerrad
Life Sciences; Volume 212, 1 November 2018, Pages 87-92

Aims
The primary goal was to assess the effects of chronic sildenafil treatment over the Achilles tendons in rats.

Main methods
Animals were divided into two groups, control and sildenafil administration (n = 5). After 60 days, the tendons were subject to biochemical and image analysis to compare tendons between the groups: collagen I and decorin content, polarisation microscopy and birefringence analysis, and tissue zymography.

Key findings
The animals exposed to sildenafil presented a much less organised tendon matrix, with reduced collagen I and non-collagenous protein content and a much higher decorin content.

Significance
The results observed in the animals can be characterised as tendinopathy, a condition not yet described as a sildenafil side effect.
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