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Chilblains and Covid-19 (Covid Toes)

Discussion in 'General Issues and Discussion Forum' started by NewsBot, Apr 11, 2020.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Chilblains in children in the time of Covid‐19: new evidence with serology assay
    C Colonna F Spinelli NA Monzani F Ceriotti C Gelmetti
    13 June 2020
     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Rash as a presenting complaint in a child with COVID‐19
    Anna Klimach Jordan Evans Jennifer Stevens Nikola Creasey
    11 June 2020
     
  3. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Cutaneous Manifestations of COVID-19: A Systematic Review
    Giulia Daneshgaran et al
    Research Square
     
  4. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    PodChatLive Episode 81 with Nadia Dembsky on Chilblains and COVID-19 ("COVID-TOES")
     
  5. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Major cluster of pediatric “ true ” primary chilblains during the COVID‐19 pandemic: a consequence of lifestyle changes due to lockdown
    Neri Iria Virdi Annalucia Corsini Ilaria Guglielmo Alba Lazzarotto Tiziana Gabrielli Liliana Misciali Cosimo Patrizi Annalisa Lanari Marcello
    13 June 2020
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Patients with specific skin disorders who are affected by COVID ‐19: what do experiences say about management strategies? : A systematic review
    Niloufar Najar Nobar Azadeh Goodarzi
    18 June 2020
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    The mystery of the COVID toes – turning evidence-based medicine on its head
    Ivan R. Bristow & Alan M. Borthwick
    Journal of Foot and Ankle Research volume 13, Article number: 38 (2020)
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultraestructural study of 7 paediatric cases
    I. Colmenero C. Santonja M. Alonso‐Riaño L. Noguera‐Morel A. Hernández‐Martín D. Andina T. Wiesner J.L. Rodríguez‐Peralto L. Requena A. Torrelo
    BJD: 20 June 2020
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Understanding the role that ‘COVID toe’ has in recognizing the potential extent of COVID-19 infections: a case study
    Alex Noakes & Sophie Majoe
    Pathogens and Global Health: 24 Jun 2020
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Pernio-like skin lesions associated with COVID-19: a case series of 318 patients from 8 countries
    Esther E.Freeman et al
    Journal of the American Academy of Dermatology; 30 May 2020
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Recent outbreak of chilblain‐like lesions is not directly related with SARS‐CoV‐2 infection
    J. Rouanet E. Lang F. Beltzung B. Evrard C. Henquell I. Joulie M. D’Incan
    26 June 2020 https://doi.org/10.1111/jdv.16776
     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    COVID‐19 and outbreak of chilblains: are they related?
    C. Lesort J. Kanitakis A. Villani E. Ducroux P. Bouschon K. Fattouh B. Bensaid M. Danset D. Jullien
    27 June 2020
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic
    Anne Herman et al
    June 25, 2020
    JAMA Dermatology

     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Assessment of Acute Acral Lesions in a Case Series of Children and Adolescents During the COVID-19 Pandemic
    Juncal Roca-Ginés et al
    JAMA Dermatol. Published online June 25, 2020. doi:10.1001/jamadermatol.2020.2340
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical "trial" was just registered:
    COVID-19 and Chilblains (ECCES)
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Chilblain‐like lesions during COVID‐19 pandemic: a serological study on a case series
    L. Rizzoli L. Collini M. Magnano S. Termine R. Barcelli S.D. Infusino P. Bauer G. Rech C. R. Girardelli R. Balestri
    01 July 2020
     
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Clinical and Histopathological Features and Potential
    Pathological Mechanisms of Skin Lesions in
    COVID-19: Review of the Literature

    Gürkan Kaya et al
    Dermatopathology 2020, 7, 3–16;: 30 June 2020
     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Dermoscopy Features of COVID-19-related Chilblains in Children and Adolescents
    Lourdes Navarro et al
    J Eur Acad Dermatol Venereol. 2020 Jul 2.
     
  20. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Cutaneous chilblains-like lesions (CCLL) versus COVID-19 toes during the pandemic. Confocal findings and proposal for new acronym, CCLL – is there a diagnostic window?
    Joanna Ludzik et al
    F1000Research 2020, 9:668
     
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Concurrent chilblains and retinal vasculitis in a child with COVID‐19
    Lucía Quintana‐Castanedo Marta Feito‐Rodríguez Celia Fernández‐Alcalde María Granados‐Fernández Dolores Montero‐Vega Ander Mayor‐Ibarguren Raúl de Lucas‐Laguna
    02 July 2020
     
  22. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Coronavirus (COVID-19) Infection–Induced Chilblains
    A Brisk Perieccrine Inflammatory Response

    Wargo, Jeffrey J. MD; Weir, Nathan M. MD, PhD; Shamma, H. Nicholas MD
    The American Journal of Dermatopathology: June 30, 2020
     
  23. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Chilblains in Children in the Setting of COVID-19 Pandemic
    David Andina et al
    Pediatr Dermatol. 2020 May;37(3):406-411
     
  24. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Most chilblains observed during the COVID‐19 outbreak occur in patients who are negative for COVID‐19 on PCR and serology testing
    L. Le Cleach L. Dousset H. Assier S. Fourati S. Barbarot C. Boulard C. Bourseau Quetier L. Cambon C. Cazanave A. Colin E. Kostrzewa C. Lesort A. Levy Roy F. Lombart … See all BJD: 06 July 2020
     
  25. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Are chilblains a skin expression of COVID-19 microangiopathy?
    Marie Baeck et al
    J Thromb Haemost. 2020 Jul 13
     
  26. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    RE: SARS-CoV-2-related chilblains in a 16 year old female
    Catharine L. Dewar, Rheumatologist, (Rheumatology, Lions Gate Hospital, North Vancouver, BC: Retired in 2020)
    13 July 2020
    I read this article (1) with interest but it raised a few concerns. In females in this age group, the association between anorexia nervosa and pernio or chilblains has been noted for several
    This was in response this article: https://www.cmaj.ca/content/cmaj/192/28/E804.full.pdf
     
  27. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    COVID-19-associated vasculitis and vasculopathy
    Richard C. Becker
    Journal of Thrombosis and Thrombolysis (2020)
     
  28. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  29. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    The differing pathophysiologies that underlie COVID‐19 associated perniosis and thrombotic retiform purpura: a case series
    C. Magro J.J. Mulvey J. Laurence S. Sanders N. Crowson M. Grossman J. Harp G. Nuovo
    22 July 2020
     
  30. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Cutaneous manifestations associated with COVID19 in children: A Systematic Review
    Seema Shah et al
    Research Square
     
  31. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  32. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries
    Esther E Freeman et al
    J Am Acad Dermatol. 2020 Aug;83(2):486-492
     
  33. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    NEWS RELEASE 7-AUG-2020
    COVID-19 - The virus and the vasculature

    In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

    The novel coronavirus SARS-CoV-2 infects the respiratory tract and in severe cases, the infection can result in lung failure, which necessitates the use of mechanical ventilation. In addition, these patients develop further complications, such as pulmonary embolisms or thromboses (clots) in their veins. Whether or not virus-associated respiratory failure is functionally related to the systemic increase in the incidence of intravascular clot formation has remained unclear. However, a new study led by LMU clinicians Leo Nicolai and Konstantin Stark, which appears in the journal Circulation, has identified a link between virus-induced changes in the blood vessels of the lung and the increased thrombotic risk. Upon post-mortem examination of the lungs of COVID-19 patients who had died of the disease, Nicolai and colleagues found many microclots within the finest branches of the pulmonary vasculature. Similar observations were made in the heart and the kidney.

    These clots were primarily made up of platelets and activated immune cells, in particular neutrophils. Detailed analysis of the thrombi suggested that an activating interaction between platelets and neutrophils is responsible for promoting intravascular coagulation. Neutrophils belong to the innate immune system and their principal task is to fight invading pathogens. Their involvement in abnormal clotting has led to the designation of this process as immunothrombosis. In COVID-19 patients, the stimulation of clot formation eventually compromises the supply of blood to nearby tissues. This in turn ultimately leads to respiratory failure, while the tendency to trigger clotting becomes systemic.

    Using multidimensional flow cytometry assays, the LMU researchers showed that in COVID-19 patients who had suffered lung failure and required mechanical ventilation, the numbers of activated neutrophils and platelets in the circulation were greatly enhanced. Since the two cell types reciprocally activate each other, these interactions lead to the formation of obstructive blood clots in the lung. In addition, activated neutrophils extrude mesh-like complexes made up of DNA and cytoplasmatic proteins, which are known as neutrophil extracellular traps (NETs). These normally serve to trap and destroy bacterial and viral pathogens, but they also play a significant role in immunothrombosis by stabilizing thrombi. While this process is initially localized in the lung exacerbating respiratory failure and result in a systemic thrombogenic state. "These findings contribute to a better understanding of the pathophysiology that underlie disease progression in COVID-19," says Konstantin Stark. "The study also identifies immunothrombosis as a promising target for the prevention and treatment of lung failure and thrombotic complications that arise in cases of COVID-19."
     
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