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Gait pattern and lower extremity alignment in children with Morquio syndrome

Discussion in 'Pediatrics' started by NewsBot, Oct 2, 2012.

  1. NewsBot

    NewsBot The Admin that posts the news.

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    Gait pattern and lower extremity alignment in children with Morquio syndrome
    Dhawale, Arjun A.; Church, Chris; Henley, John; Holmes, Laurens Jr; Thacker, Mihir M.; Mackenzie, William G.; Miller, Freeman
    Journal of Pediatric Orthopaedics B: 22 September 2012
     
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    NewsBot The Admin that posts the news.

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    Morquio syndrome

    Morquio syndrome (referred to as mucopolysaccharidosis IV, MPS IV, Morquio-Brailsford syndrome, or Morquio)[1] is a rare metabolic disorder in which the body cannot process certain types of mucopolysaccharides (long chains of sugar molecules), which the body uses as lubricants and shock absorbers. This birth defect, which is autosomal recessive, is thus a lysosomal storage disorder that is usually inherited.[2]:544 In the US, the incidence rate for Morquio is estimated at between 1 in 200,000 and 1 in 300,000 live births.[1]

    The build-up or elimination of mucopolysaccharides, rather than processing by their usual biochemical pathways, causes various symptoms. These involve accumulation of keratan sulfate.[3]

    1. ^ a b "MPS IV (Morquio syndrome)". MPSSociety.org. National MPS Society. Retrieved 14 January 2015.
    2. ^ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
    3. ^ Prat C, Lemaire O, Bret J, Zabraniecki L, Fournié B (May 2008). "Morquio syndrome: Diagnosis in an adult". Joint Bone Spine. 75 (4): 495–8. doi:10.1016/j.jbspin.2007.07.021. PMID 18456538.
     
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